Web Application and Services for Methodologically Rigorous Animal Study Design

用于方法上严格的动物研究设计的网络应用程序和服务

基本信息

批准号：
9247079
负责人：
Yun Wang
金额：
$ 4万
依托单位：
TEMPEST TECHNOLOGIES
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9247079
关键词：
Analysis of Variance Animal Experimentation Animal Experiments Animal Model Animal Structures Animal Testing Animals Architecture Biological Sciences Case Study Cessation of life Client Collaborations Complex Computer software Development Distress Engineering Ensure Environment Equilibrium Ethics Experimental Designs Foundations Goals Hand Housing Internet Lead Life Linear Models Literature Medicine Methods Online Systems Pain Persons Phase Process Questionnaires Randomized Reproducibility Research Research Design Research Personnel Sample Size Science Scientist Side Software Design Software Tools Staging Statistical Computing System Techniques Testing Time Translating base cloud based computerized tools design experience experimental analysis improved interest prevent prospective prototype public health relevance research study software as a service software development statistics text searching tool treatment planning web app web services

项目摘要

DESCRIPTION: Our goal in this project is to develop a web-application to guide researchers in the efficient and effective design of animal studies that balance the competing needs of minimizing animal use and providing rigorous, repeatable results. Three basic ideas, which translate directly into our three specific aims, form the foundation of our proposed tool. First an foremost is to place science before statistics: develop the science plan for a pilot, exploratory o hypothesis-driven study with a clear idea of the effects of interest and structure of the animal selection, housing, and treatment plan. Second is a prospective examination of sample size and effect size through power computations. Third is ready access to expert support with design and statistics professionals. The proposed study is the first phase in the development of a web-application for experimental design and analysis. Our Phase I effort will demonstrate the concept with a prototype dynamic web application that provides qualitative and quantitative decision support together with person-to-person on-line chat capability for rapid technical assistance with study design. In collaboration with our teammates at UC San Diego and UC Davis, we will develop a set of example case studies from their extensive animal research experience, ranging both in study goals and problem complexity. From these examples, we will develop use cases to design the user-system interactions that will form the software development foundation.

描述：我们在该项目中的目标是开发一个网络应用程序来指导研究人员高效且有效地设计动物研究，以平衡最小化动物使用和提供严格、可重复结果的竞争需求，这三个基本想法可直接转化为。我们的三个具体目标构成了我们提出的工具的基础，首先是将科学置于统计之前：为试点、探索性或假设驱动的研究制定科学计划，并清楚地了解兴趣和结构的影响。动物的选择、饲养和治疗第二是通过功效计算对样本量和效应量进行前瞻性检查。第三是准备获得设计和统计专业人员的专家支持，这是用于实验设计和分析的网络应用程序开发的第一阶段。我们的第一阶段工作将通过原型动态网络应用程序展示这一概念，该应用程序提供定性和定量决策支持以及人与人之间的在线聊天功能，以便与我们在加州大学圣地亚哥分校的团队成员合作，为研究设计提供快速技术援助。和加州大学戴维斯分校，我们将开发一组案例研究他们在研究目标和问题复杂性方面拥有丰富的动物研究经验，我们将根据这些示例开发用例来设计用户与系统的交互，从而奠定软件开发的基础。