Resource Support Core

资源支持核心

基本信息

批准号：
10599821
负责人：
Ralitza Gueorguieva
金额：
$ 13.22万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-10 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10599821
关键词：
Address Alcohol consumption Animals Big Data Biological Assay Biosensor Blood alcohol level measurement Clinical Research Clinical Trials Data Monitoring Committees Collaborations Communication Consultations DSM-V Data Data Analytics Data Set Disease Doctor of Philosophy Ensure Environment Ethanol Metabolism Female Goals Gonadal Steroid Hormones Human IACUC Impulsivity Institution Institutional Review Boards Investigation Leadership Location Medical Menstrual cycle Methods Modernization Monitor Moods Pilot Projects Procedures Public Health Quality Control Recording of previous events Reporting Reproductive History Research Research Personnel Resources Safety Sampling Sex Differences Stress System Techniques Time Tobacco use Training Translational Research Translations Woman alcohol use disorder behavioral phenotyping clinical investigation craving cytokine data management data resource demographics design digital drinking drinking behavior ethnic minority executive function human subject hypothalamic-pituitary-adrenal axis innovation male meetings men pre-clinical psychiatric symptom racial minority recruit screening social therapy development wearable sensor technology

项目摘要

Rates of alcohol use disorders (AUDs) in women have increased by 84% over the last decade, relative to the 35% increase in men. The Resource Support Core of the Yale-SCORE is designed to support the dramatic need for translational research to address the concerning increase in rates of AUD among women. The key purpose of the Resource Support Core is to provide essential research-related resources to Yale-SCORE investigators, trainees, and collaborating researchers. The resources provided will serve to maximize the quality of the data, the comparability of data across Projects, and increase dynamic communication among Yale-SCORE researchers to maximize the translation of results across projects and within the greater research environment. The Core will: 1) Provide expert consultation, management, and coordination of IRB/IACUC approvals, regulatory procedures and data safety monitoring, as required for animal and human Projects and Pilots. 2) Generate comprehensive strategies to recruit equal numbers of women and men and ensure racial/ethnic minority diversity in samples of human subjects into all Yale-SCORE clinical studies. Ensure that equal numbers of female and male animals are studied in preclinical projects. 3) Provide modern data management and analytical techniques that incorporate state-of-the-art SABV approaches across the conceptualization, methods, analysis, and reporting of all Yale-SCORE findings. 4) Provide centralized training and quality control of core assessments and assays across animal and human studies to maximize the scientific yield across studies. 5) Incorporate an innovative biosensor system into Yale-SCORE human projects to provide a wealth of data to examine sex differences in ‘real-world’ naturalistic drinking behavior (e.g., blood alcohol levels, drinking topography) and context of drinking (e.g., time, location, activity, social milieu) in women and men meeting criteria for AUD. This will be the first ever dataset of its kind, providing an estimated 3 billion data points. 6) Leverage available national big-data resources to expand our T1 to T4 translational focus on sex differences in alcohol use.

过去 10 年间，女性酒精使用障碍 (AUD) 的比例相对于男性增加了 84% 耶鲁大学 SCORE 的资源支持核心旨在支持戏剧性的增长 35%。需要进行转化研究来解决女性 AUD 发病率上升的问题。资源支持核心的目的是为耶鲁大学 SCORE 提供必要的研究相关资源所提供的资源将有助于最大限度地提高研究人员、实习生和合作研究人员的能力。数据质量、项目间数据的可比性，并增加项目之间的动态沟通耶鲁大学 SCORE 研究人员最大限度地跨项目和更广泛的研究成果转化核心将： 1) 提供 IRB/IACUC 的专家咨询、管理和协调。动物和人类项目所需的批准、监管程序和数据安全监测 2) 制定全面的战略，招募同等数量的女性和男性，并确保确保所有耶鲁 SCORE 临床研究中人类受试者样本的种族/族裔多样性。在临床前项目中研究了相同数量的雌性和雄性动物 3) 提供现代数据。管理和分析技术，结合了最先进的 SABV 方法所有耶鲁 SCORE 结果的概念化、方法、分析和报告 4) 提供集中培训。对动物和人类研究的核心评估和检测进行质量控制，以最大限度地提高 5) 将创新的生物传感器系统纳入耶鲁 SCORE 人类项目。提供大量数据来检查“现实世界”自然饮酒行为中的性别差异（例如，血液酒精浓度、饮酒地形）和饮酒背景（例如时间、地点、活动、社交环境）符合 AUD 标准的女性和男性这将是此类数据集的第一个，提供了估计值。 30亿个数据点 6) 利用现有的国家大数据资源来扩展我们的T1到T4转化。关注饮酒方面的性别差异。