Caffeine Disposition After Inhalation

吸入后咖啡因的处置

• 批准号: 8847697
• 负责人: Steven Casey Laizure
• 金额: $ 7.39万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8847697
• 关键词: Address; Adverse effects; Alcohol abuse; Alcohol consumption; Alcoholic Intoxication; Alcohols; Attention; Behavioral; Beverages; Blood Pressure; Breathing; Caffeine; Cardiovascular system; Child; Coffee; Consumption; Data; Deposition; Devices; Dosage Forms; Dose; Drug Kinetics; Drunk driving; Epidemic; Exposure to; Goals; Health; Heart Rate; Inhalation Drug Administration; Intoxication; Marketing; Measures; Methods; Moods; Oral; Oral Administration; Oral cavity; Pharmacodynamics; Phase; Physiological; Plasma; Powder dose form; Reporting; Risk; Shapes; Solutions; Tea; Testing; Time; Tube; United States Food and Drug Administration; Violence; absorption; alcohol effect; alcohol related problem; caffeine abuse; dietary supplements; drinking; high risk; insight; sexual assault; soft drink; volunteer; young adult

DESCRIPTION (provided by applicant): The co-abuse of energy drinks with alcohol has reached epidemic levels in young adults. This combination encourages heavy binge alcohol use, and is associated with an increase in alcohol- related problems including severe intoxication, violence, sexual assault, and drunk driving. This co-abuse of caffeine and alcohol coincides with the introduction of energy drinks that heralded the consumption of high caffeine content beverages in children and young adults, who prior to the availability of energy drinks had limited exposure to high caffeine levels. Recently, a new inhaled form of caffeine (Aeroshot TM) was introduced into the U.S. market as a dietary supplement and could expose young adults to even higher levels of caffeine posing an even greater risk of co-abuse with alcohol than energy drinks. AeroshotTM is a caffeine delivery device the size and shape of a lipstick case. By inhaling from one end of the tube a fine powder containing 100 mg of caffeine is deposited into the oral cavity and upper airway. How much and how fast caffeine gets into the body using this method of administration are unknown. These are critical questions, because the disposition of caffeine following administration especially during the crucial absorption phase is an important factor influencing abuse potential. Our overall hypothesis is that caffeine administration by inhalation results in more rapid absorption of caffeine and greater physiologic and behavioral effects than administration by oral solution. We plan to evaluate this hypothesis by completing specific aim 1) determine the plasma concentration-time profile of caffeine and its major metabolites after administration by oral solution and inhalation, and specific aim 2) determine the cardiovascular and mood effects of caffeine after administration by oral solution and inhalation. We expect the results from this study to provide important insight into the abuse potential of the AeroshotTM device alone and in combination with alcohol. Our long term goal is to define the pharmacodynamics of caffeine- alcohol abuse and the pharmacokinetic factors contributing to high-risk alcohol use in young adults.

描述（由申请人提供）：与酒精的共同滥用能量饮料已达到年轻人的流行水平。这种组合鼓励大量饮酒，并且与酒精相关的问题增加，包括严重的中毒，暴力，性侵犯和醉酒驾驶。这种咖啡因和酒精的共同滥用与引入能量饮料的引入，这些饮料预示着儿童和年轻人的咖啡因含量饮料的消费，在供应能量饮料之前，他们对高咖啡因水平的影响有限。最近，将一种新的吸入形式的咖啡因（Aeroshot TM）引入了美国市场，作为一种饮食补充剂，可能使年轻人面临更高水平的咖啡因，其与能量饮料相比，与能量饮料共同饮酒的风险更大。 AeroShottm是一种咖啡因递送装置，其大小和形状是口红盒的大小和形状。通过从管的一端吸入一个含有100毫克咖啡因的细粉被沉积在口腔和上呼吸道中。使用这种给药方法，咖啡因进入体内的速度和速度尚不清楚。这些是关键问题，因为咖啡因在给药后的处理，尤其是在关键吸收阶段，是影响滥用潜力的重要因素。我们的总体假设是，与口服溶液相比，通过吸入咖啡因的给药会导致咖啡因和生理和行为效应的吸收更快。我们计划通过完成特定目的来评估这一假设1）确定咖啡因及其主要代谢产物在通过口服溶液和吸入给药后的主要代谢产物的血浆浓度时间谱图，以及特定的目标2）确定通过口服溶液给药后咖啡因的心血管和情绪影响。我们希望这项研究的结果能够单独使用AeroShottm设备的滥用潜力并与酒精结合使用。我们的长期目标是定义咖啡因滥用咖啡因的药效学和导致年轻人高危饮酒的药代动力学因素。

项目成果

Measurement of caffeine and its three primary metabolites in human plasma by HPLC-ESI-MS/MS and clinical application.

• DOI: 10.1002/bmc.3900
• 发表时间: 2017-06
• 期刊: Biomedical chromatography : BMC
• 作者: Chen F;Hu ZY;Parker RB;Laizure SC
• 通讯作者: Laizure SC

Comparison of caffeine disposition following administration by oral solution (energy drink) and inspired powder (AeroShot) in human subjects.

人类受试者口服溶液（能量饮料）和激发粉末（AeroShot）后咖啡因处置的比较。

• DOI: 10.1111/bcp.13389
• 发表时间: 2017
• 期刊: British journal of clinical pharmacology
• 影响因子: 3.4
• 作者: Laizure,SCasey;Meibohm,Bernd;Nelson,Kembral;Chen,Feng;Hu,Zhe-Yi;Parker,RobertB
• 通讯作者: Parker,RobertB