Enhancing Laser Lithotripsy via Nanoparticle Fine-Tuned NIR absorption

通过纳米颗粒微调近红外吸收增强激光碎石术

基本信息

批准号：
10596707
负责人：
CHRISTINE K PAYNE
金额：
$ 39万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-21 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10596707
关键词：
Ablation Address American Applications Grants Benign Biomechanics Biophotonics Clinical Collaborations Communities Computer Models Data Data Collection Data Scientist Development Plans Disease Doctor of Philosophy Dust Engineering Faculty Fiber Fostering Foundations Frequencies Future Goals Health Expenditures Holmium Hydrogels In Situ In Vitro Information Resources Injury to Kidney Interdisciplinary Study Irrigation Journals Kidney Kidney Calculi Knowledge Laser Lithotripsy Lasers Lithotripsy Mentored Clinical Scientist Development Program Modeling Names Nanotechnology National Institute of Diabetes and Digestive and Kidney Diseases Operative Surgical Procedures Optics Pain Paper Patients Play Procedures Published Comment Renal Tissue Research Research Activity Research Personnel Research Project Grants Risk Role Safety Saline Shock Societies Solid Technology Temperature Thulium Time Toxic effect Universities Ureteroscopy Urinary Calculi Urogenital Diseases Urology absorption base career development cell injury cost experience improved in vivo innovation multidisciplinary nanomaterials nanoparticle novel strategies operation optimal treatments porcine model programs recruit success synergism theories tissue injury treatment choice urologic

项目摘要

ABSTRACT Ureteroscopy (URS) via laser lithotripsy (LL) is the treatment of choice for urinary stone disease (USD), which is the second most costly urologic condition in the US with an annual healthcare expenditure over $2 billion. The recent clinical introduction of high power/high frequency Holmium (Ho): YAG lasers and Thulium Fiber Laser (TFL) have fundamentally altered the mode of LL operation. Instead of the conventional fragmenting mode with basket extraction of sizable fragments, contemporary LL is often performed using dusting and pop-dusting modes that pulverize stone to dust in situ without the need for fragment extraction. The challenges in dusting and pop-dusting at present, however, are three-fold: 1) the mechanism of action is not fully understood, 2) the optimal treatment condition varies significantly with stone compositions, and 3) rapid temperature rise is produced during high power pop-dusting. Consequently, there is an unmet need to develop new and clinically deployable technologies capable of improving the treatment efficiency regardless of stone compositions, shortening the procedure time, while concomitantly lessening the risk of renal tissue injury. The overarching goal of this Duke University FORWARD Urology Center (P20) application is to foster and support the career development of Dr. Po-Chun Hsu, PhD who is a promising early-stage investigator with expertise in nanotechnology, yet new to the field of USD and benign urology. The Center's Research Project has three Specific Aims focusing on (1) Developing biologically safe nanoparticles with absorption peak optimized for Ho:YAG laser (=2.1 m) and TFL (=1.94 m); (2) Investigating the effects of nanoparticle-enhanced pop- dusting in a hydrogel-based kidney model, and (3) Exploring the effects of nanoparticle-enhanced pop-dusting in a porcine model. The Center's Administrative Core has two Specific Aims: (1) Facilitating productive collaborations among the Research Project Team and with the broader CAIRIBU research community, and (2) Fostering and supporting the career development plan for Dr. Hsu. Furthermore, we will leverage the knowledge, resources, and experience accumulated from a recently completed P20 exploratory center on LL at Duke (PI: Zhong, PhD), together with the support of the NIDDK CAIRIBU Interactions Core (PI: Penniston, PhD) and the Columbia U54 Center (co-PI: Barasch, PhD/MD) on assessment of renal injury in a porcine model. Synergies, preliminary data, and knowledge created by this P20 FORWARD program will support future R01 applications on nanotechnology-enhanced LL and the broad range of USD research through the NIDDK CAIRIBU program.

抽象的通过激光碎石术 (LL) 进行输尿管镜检查 (URS) 是泌尿系结石病 (USD) 的首选治疗方法，美国第二昂贵的泌尿系统疾病，每年的医疗支出超过 20 亿美元。最近临床介绍高功率/高频钬 (Ho)：YAG 激光器和铥光纤激光器 (TFL) 从根本上改变了 LL 操作模式，而不是传统的分段模式。篮子提取相当大的碎片，当代的LL通常使用除尘和流行除尘来进行无需提取碎片即可将石头原位粉碎成粉末的模式除尘方面的挑战。然而，目前的流行喷粉有三个方面：1）作用机制尚不完全清楚，2）最佳处理条件随石材成分的不同而显着变化，并且 3) 温度快速上升在高功率喷粉测试过程中产生的，尚未满足开发新的和临床的需求。无论石材成分如何，都能够提高处理效率的可部署技术，缩短手术时间，同时降低肾组织损伤的风险。杜克大学 FORWARD 泌尿中心 (P20) 申请的目的是促进和支持职业生涯 Po-Chun Hsu 博士的发展，他是一位有前途的早期研究人员，拥有以下方面的专业知识该中心的研究项目有三个。具体目标集中于 (1) 开发生物安全的纳米颗粒，其吸收峰经过优化 Ho:YAG 激光 (l=2.1 m) 和 TFL (l=1.94 m) (2) 研究纳米粒子增强 pop- 的影响在基于水凝胶的肾脏模型中撒粉，以及（3）探索纳米粒子增强的流行撒粉的效果在猪模型中，该中心的管理核心有两个具体目标：(1) 促进生产。研究项目团队之间以及与更广泛的 CARIBU 研究界的合作，以及 (2) 此外，我们将利用知识，促进和支持许博士的职业发展计划。杜克大学最近建成的 P20 法学探索中心积累了资源和经验（PI：钟博士），以及 NIDDK CAIRIBU 交互核心（PI：Penniston 博士）和哥伦比亚 U54 中心（联合 PI：Barasch，博士/医学博士）对猪模型肾损伤的评估。 P20 FORWARD 计划创建的初步数据和知识将支持未来的 R01 应用通过 NIDDK CARIBU 计划进行纳米技术增强的 LL 和广泛的美元研究。