Preventing Lyme Disease Exposure Among Outdoor Workers

预防户外工作者接触莱姆病

• 批准号: 9131735
• 负责人: Thomas N Mather
• 金额: $ 50.37万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9131735
• 关键词: Preventing; Lyme; Disease; Exposure; Among

 DESCRIPTION (provided by applicant): Lyme and other tick-borne diseases pose a significant health threat to outdoor workers. In a double - blind randomized controlled trial (RCT) in North Carolina outdoor workers, we previously showed that long-lasting permethrin-impregnated (LLPI) clothing provided >80% protection for one year against Lone Star tick bites among outdoor workers in North Carolina. But there are three issues that need to be addressed before this finding can be translated into policy: 1) Do LLPI clothing protect t against blacklegged ticks, the vector for Lyme disease, babesiosis and anaplasmosis, as well as against the Lone Star tick? 2) What levels of permethrin and its metabolites are absorbed, and are they potentially toxic? 3) Why did the LLPI clothing in our previous study lose efficacy after a year? To answer these questions, we propose a two year double-blind RCT with 200 outdoor workers in Lyme endemic areas of the Northeast. Outdoor workers from the National Park Service, the Rhode Island Department of Environmental Management, and NationalGrid will be randomly assigned to the treatment or control group. All study subjects will fill out weekly tick logs, collct attached ticks for later speciation and pathogen detection, and submit annual serum samples to test for exposure to tick-borne pathogens. A randomly selected subset of subjects also will be asked to submit urine samples for permethrin metabolite analysis at several time points during follow-up. Others will be asked to submit worn items of clothing for tick knockdown testing and permethrin content analysis at the end of the first and second years of field testing. This project specifically addresses the following NIOSH Priority Goals for Extramural Research: Goal 2: Reduce deleterious health and safety outcomes in workers more susceptible to injury or illness due to circumstances limiting options for safeguarding their own safety and health, Goal 7: Improve the health and well-being of forestry workers by reducing occupational causes or contributing factors to acute and chronic illness and disease. This research will address the agriculture, forestry, and fishing sector and personal protective technology cross-sector by evaluating the protective effectiveness and toxicological risk of long-lasting permethrin impregnated clothing for prevention of tick bites and tick-borne disease among forestry and utility workers and park rangers. The results of this study could help protect hundreds of thousands of outdoor workers with exposure to ticks and tick-borne pathogens.

 描述（由适用提供）：莱姆和其他tick传播疾病对户外工人构成重大健康威胁。在双盲随机对照试验（RCT）中 在北卡罗来纳州的户外工人中，我们先前表明，持久的氯菊酯浸渍（LLPI）服装提供了一年> 80％的保护，以防止北卡罗来纳州的户外工人中的孤星tick滴。但是，在这一发现可以转化为政策之前，需要解决三个问题：1）LLPI服装是否可以预防黑腿tick虫，莱姆病的矢量，Babesiosis和Onaplasmasis，以及反对孤星tick虫？ 2）苄氯菊酯及其代谢产物的水平被吸收，它们是否有毒？ 3）为什么LLPI服装在我们以前的研究中会失去一年后的效率？为了回答这些问题，我们提出了两年的双盲RCT，其中有200名室外工人在东北莱姆流行地区。国家公园管理局，罗德岛环境管理部和国家格里德的户外工人将随机分配给治疗或对照组。所有研究对象都将填写每周的tick记录，COLCT附有以后的规格和病原体检测，并提交年度血清样本以测试暴露于tick传播的病原体。随机选择的受试者将随机选择的子集在随访期间在几个时间点提交尿液样本以进行苄氯菊酯代谢物分析。将要求其他人在现场测试的第一年和第二年结束时提交服装的崇拜物品，以进行tick敲击测试和苄氯菊酯含量分析。这个项目 专门针对以下NIOSH研究外校外研究的优先目标：目标2：由于限制了保护自己的安全性和健康状况的选择，减少更容易受到伤害或疾病的工人的健康和安全成果，改善林业工人的健康和福祉，通过减少职业事业或促成急性和疾病的因素和疾病。这项研究将通过评估持久的氯菊酯浸渍服装的受保护的有效性和毒理学风险来预防林业和公用事业工人和公园游骑兵的tick虫叮咬和tick虫病，来解决农业，林业和捕鱼部门以及个人保护的技术跨部门。这项研究的结果可能有助于保护成千上万的户外工人，接触tick和tick虫病原体。