San Francisco-Rio de Janeiro collaborative research on HIV prevalence, risk, and biomedical prevention interventions among young men who have sex with men

旧金山-里约热内卢合作研究男男性行为青年中的艾滋病毒患病率、风险和生物医学预防干预措施

• 批准号: 10593960
• 负责人: BEATRIZ GRINSZTEJN
• 金额: $ 11.05万
• 依托单位: PUBLIC HEALTH FOUNDATION ENTERPRISES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-10 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593960
• 关键词: AIDS prevention; Acute; Address; Adherence; Age; American; Biological Markers; Biomedical Research; Black race; Brazil; CD4 Lymphocyte Count; California; Caring; Cities; Clinical; Clinical Trials; Collaborations; Cross-Sectional Studies; Detection; Development; Diagnosis; Disparity; Drops; Effectiveness; Epidemic; Ethics; Face; Foundations; Future; HIV; HIV Infections; HIV Seronegativity; HIV diagnosis; Health; Health Services; Incidence; Infection; Interruption; Intervention; Investigation; Investments; Joints; Knowledge; Link; Measures; Methods; Minor; Minority Men; Outcome; Parents; Participant; Patients; Persons; Phylogenetic Analysis; Policies; Population; Prevalence; Prevention Research; Prevention program; Provider; Public Health; RNA; Race; Reporting; Research; Research Personnel; Resources; Respondent; Risk; Risk Behaviors; Sampling; San Francisco; Scientist; Sexual Health; Sexually Transmitted Diseases; South America; Surveys; Technology; Testing; United States National Institutes of Health; Viral; Viral Load result; acute infection; black men who have sex with men; experience; improved; innovation; intervention program; low and middle-income countries; men who have sex with men; novel strategies; pilot test; population based; pre-exposure prophylaxis; prevent; preventive intervention; programs; racial disparity; rapid diagnosis; scale up; social media; success; translational framework; transmission process; uptake; young man; young men who have sex with men

ABSTRACT As San Francisco’s HIV epidemic is set to reach zero infections, Rio de Janeiro is experiencing a resurgence in new reported HIV cases among MSM. San Francisco’s success can be attributed to effective biomedical interventions, namely: rapid diagnosis, immediate ART, sustained viral load suppression, wide uptake of PrEP, and interrupting new clusters of transmission. In Brazil, however, uptake of these biomedical interventions has so far been insufficient to reverse the epidemic, despite being the first low/middle income country to provide free ART to all persons with HIV, participation in clinical trials proving PrEP efficacy, and national policy to provide free PrEP. Meanwhile, young MSM, particularly Black/Afro-Brazilians, have high HIV incidence, low viral suppression, and poor PrEP adherence. We therefore propose collaborative research between the San Francisco Department of Public Health and the Oswaldo Cruz Foundation (Fiocruz) in Rio de Janeiro. We will focus on identifying the drivers of HIV infection, ways to address barriers to biomedical interventions, and identifying the hurdles to including young MSM in biomedical research. Methods include a cross-sectional survey of MSM age 18-24 using respondent-driven sampling adapted for social media-based sampling; development of a technology-based rapid ART and PrEP engagement and retention intervention; and a qualitative study of MSM age 15-17, their parents, and providers of sexual health services to better understand the onset of risk and the feasibility of increasing inclusion of minors in biomedical HIV research and intervention programs. San Francisco stands as an American test case for the elimination of HIV, yet remaining challenges exist in reaching young and minority MSM. Rio de Janeiro is an engine of HIV research in South America, yet faces challenges in reaping the benefit of proven biomedical interventions for MSM. The proposed US-Brazil research collaboration will provide mutual benefit in increasing the effectiveness of biomedical interventions to reverse the HIV epidemic among MSM in Brazil and address remaining disparities in the US.

抽象的 随着旧金山的艾滋病毒流行将达到零感染，里约热内卢正在经历 旧金山 MSM 中新报告的艾滋病毒病例的复苏可能是成功的原因。 归因于有效的生物医学干预措施，即：快速诊断、立即 ART、 持续的病毒载量抑制、PrEP 的广泛吸收以及阻断新的病毒群 然而，在巴西，迄今为止，这些生物医学干预措施的采用尚未取得进展。 尽管是第一个提供援助的低/中等收入国家，但仍不足以扭转这一流行病 向所有 HIV 感染者免费提供 ART，参与证明 PrEP 功效的临床试验，以及 国家政策提供免费的 PrEP 同时，年轻的男男性行为者，特别是黑人/非洲裔巴西人， HIV 发病率高、病毒抑制率低且 PrEP 依从性差。 旧金山公共卫生部和 位于里约热内卢的奥斯瓦尔多·克鲁兹基金会 (Fiocruz) 我们将重点关注确定驱动因素。 HIV 感染、解决生物医学干预障碍的方法以及识别障碍 将年轻的 MSM 纳入生物医学研究 方法包括一项横断面调查。 18-24 岁的 MSM，采用受访者驱动抽样，适用于基于社交媒体的抽样； 开发基于技术的快速 ART 和 PrEP 参与和保留 干预；以及针对 15-17 岁 MSM、其父母和性服务提供者的定性研究 卫生服务，以更好地了解风险的发生以及增加包容性的可行性 旧金山的未成年人参与生物医学艾滋病毒研究和干预计划。 美国消除艾滋病毒的测试案例，但在影响年轻人方面仍存在挑战 里约热内卢是南美洲艾滋病毒研究的引擎，但也面临着挑战。 为 MSM 获得经过验证的生物医学干预措施的益处所面临的挑战。 美国和巴西的研究合作将在提高有效性方面提供互惠互利 生物医学干预措施扭转巴西 MSM 中的艾滋病毒流行并解决 美国仍存在差距。

项目成果

Interpersonal Violence and Passing: Results from a Brazilian Trans-specific Cross-sectional Study.

人际暴力和传递：巴西跨性别者横断面研究的结果。

• 发表时间: 2022
• 影响因子: 2.5
• 作者: Peixoto, Eduardo Mesquita;de Azevedo Oliveira Knupp, Virginia Maria;Soares, Jesilaine Resende Teixeira;Depret, Davi Gomes;de Oliveira Souza, Cleo;Messina, Maria Eduarda Dantas;de Mello Andrade, Lívia Machado;de Melo, Luciana Catarina Santos;de Fig
• 通讯作者: de Fig

Correction to: The Prevalence of HIV Among Men Who Have Sex With Men (MSM) and Young MSM in Latin America and the Caribbean: A Systematic Review.

更正：拉丁美洲和加勒比地区男男性行为者 (MSM) 和年轻 MSM 中艾滋病毒的流行情况：系统回顾。

• 发表时间: 2022-01
• 影响因子: 4.4
• 作者: Coelho, Lara E;Torres, Thiago S;Veloso, Valdilea G;Grinsztejn, Beatriz;Jalil, Emilia M;Wilson, Erin C;McFarland, Willi
• 通讯作者: McFarland, Willi