Visual Function & Morphology Core

视觉功能

基本信息

批准号：
10593134
负责人：
Amanda Susanne Gatesman-Ammer
金额：
$ 22.55万
依托单位：
WEST VIRGINIA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-20 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10593134
关键词：
Adult Affect Age Age related macular degeneration American Basic Science Behavior Biological Assay Biology Biophysics Blindness Centers of Research Excellence Child Chronic Communities Complex Contract Services Core Facility Data Analyses Development Diabetic Retinopathy Disease Dissection Electron Microscope Electroporation Ensure Environment Equipment Experimental Designs Extramural Activities Eye Eye diseases Fees Funding Genetic Glaucoma Goals Health Hour Infrastructure Injections Institution Investments Journals Lead Life Mediating Methods Molecular Morphology Ocular Pathology Persons Postdoctoral Fellow Preparation Prevalence Principal Investigator Process Productivity Publications Quality of life Research Research Infrastructure Research Personnel Research Project Grants Resources Retinitis Pigmentosa Sampling Services Slide Structure Students Syndrome System Technology Training Translational Research Transmission Electron Microscopy Universities Vision Vision Tests Vision research Visual Visual Acuity Visual impairment Wages West Virginia age related aging population cone-rod dystrophy data acquisition design disability experience fluorescence imaging histological specimens imaging modality imaging system improved instrumentation member microscopic imaging multidisciplinary new technology novel therapeutic intervention operation programs quality assurance recruit research and development single-molecule FRET subretinal injection success superresolution imaging superresolution microscopy therapeutic development tool transmission process ultrasound vision science visual process

项目摘要

Core 001 (039): Visual Function & Morphology Core (VFM Core), Gatesman-Ammer, Core Lead PROJECT SUMMARY/ABSTRACT The Visual Function & Morphology Core (VFM Core) has emerged from strategic institutional investments in super resolution microscopy and functional visual assessment equipment, as well as leveraged support from IDeA-funded programs (CoBRE, CTR, INBRE) that have provided new technologies, service contracts and salary support. The VFM Core will be used by all four proposed research projects, as well as other members of the VS-CoBRE, where it will serve as the focal point for experimental design, data acquisition and functional analysis. The VFM Core will also provide equipment oversight, training, and assistance as needed to promote an environment conducive to success for the project leaders of the Visual Sciences Center of Excellence. In addition to equipment and expertise, the VFM Core will offer technical assistance in transmission electron microscopy preparations, histology sample preparation, ERG/OKR assessments, and electroporation/orbital injections. Existing capabilities that have been built with institutional support will also be incorporated into the VFM Core. These include four super-resolution microscopy systems, a transmission electron microscope, brightfield and fluorescent imaging systems, and visual function assessment equipment. The proposal describes services provided by the facility along with its management plan, fee structure, prioritization, quality assurance plan, and strategies to sustain the facility over the life of the project and beyond. The Specific Aims are to: 1) advance the basic and translational research and provide the necessary tools and expertise to advance productivity of the Visual Sciences CoBRE Research Project Leaders, and 2) develop the VFM Core for investigators who share the overarching goal to understand the complexities of ocular anomalies that may lead to decreases in visual acuity and blindness. The VFM Core will be a valued and necessary part of the infrastructure needed to develop the VS-CoBRE and to bring advances in visual sciences that will positively impact the lives of people with visual impairments.

核心 001 (039)：视觉功能和形态核心（VFM 核心），Gatesman-Ammer，核心负责人项目概要/摘要视觉功能和形态核心（VFM Core）源于战略机构投资超分辨率显微镜和功能性视觉评估设备，以及来自 IDeA 资助的计划（CoBRE、CTR、INBRE）提供了新技术、服务合同和薪资支持。 VFM 核心将被所有四个拟议的研究项目以及其他成员使用 VS-CoBRE，它将作为实验设计、数据采集和功能的焦点分析。 VFM 核心还将根据需要提供设备监督、培训和援助，以促进为视觉科学卓越中心的项目负责人提供一个有利于成功的环境。除了设备和专业知识外，VFM Core 还将提供传输电子方面的技术援助显微镜制备、组织学样品制备、ERG/OKR 评估和电穿孔/轨道注射。在机构支持下建立的现有能力也将纳入 VFM 核心。其中包括四个超分辨率显微镜系统、一个透射电子显微镜、明场和荧光成像系统以及视觉功能评估设备。该提案描述了该设施提供的服务及其管理计划、费用结构、优先顺序、质量保证在项目生命周期及之后维持设施的计划和策略。具体目标是：1) 推进基础研究和转化研究，并提供必要的工具和专业知识来推进视觉科学 CoBRE 研究项目负责人的生产力，以及 2) 开发 VFM 核心研究人员的总体目标是了解可能导致的眼部异常的复杂性导致视力下降和失明。 VFM 核心将是一个有价值且必要的部分开发 VS-CoBRE 所需的基础设施并带来视觉科学的进步，这将积极促进影响视力障碍人士的生活。