TB-RICC 3.0

基本信息

批准号：
10593544
负责人：
BRUNO DE BEZERRIL ANDRADE
金额：
$ 393.34万
依托单位：
RUTGERS BIOMEDICAL AND HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10593544
关键词：
Africa Architecture Area Asia Biological Markers Biometry Biotechnology Brazil COVID-19 China Clinical Clinical Research Clinical Trials Cohort Studies Collaborations Collection Common Data Element Communication Country Data Data Collection Data Element Development Diagnostic Diagnostics Research Elements Ensure Epidemiology Feedback Foundations Generations Geographic Locations Goals Grant HIV/TB Human Immunology India Indonesia International Intervention Studies Korea Laboratories Leadership Logistics Mentors Monitor Observational Study Performance Pharmaceutical Preparations Population Proteomics Protocols documentation Publishing Quality Control Research Research Design Research Methodology Research Personnel Research Support Review Committee Science Site South Africa South America Specimen Structure Technology Translational Research Treatment outcome Tuberculosis Vaccines Validation biobank biomarker evaluation data centers data harmonization data hub data management data standards design electronic data falls frontier innovation insight learning materials multiple omics nano-string novel diagnostics predictive marker programs prospective response sample collection tool transcriptomics tuberculosis diagnostics working group

项目摘要

TB-RICC 3.0 is designed to support the Regional Prospective Observational Research Tuberculosis (RePORT) Consortium to produce the highest quality observational and interventional research on tuberculosis (TB), TB-HIV, and TB-COVID-19. To accomplish this goal, TB-RICC 3.0 will: i) collaborate with RePORT Country-Network Data Centers and Biorepositories to ensure that common data elements (CDE) of the Common Protocol and Specimen Tracking are accessible through the Global Data Template; ii) organize and/or strengthen select sites to participate in diagnostic studies and clinical trials; and iii) support the RePORT Country-Networks to ensure further development of TB diagnostic laboratories, TB- RICC 3.0 specialized laboratories, and biorepositories. Aims of TB-RICC 3.0 are: Coordinating Center Structure and Function: develop a Leadership Group and Executive Committee; assure effective communication internally and externally; establish a Data Hub to provide seamless data management from collection to analysis; establish Scientific Working Groups; a Scientific Review Committee and an Administrative Core; facilitate grant submissions to potential funders and partners. Data Harmonization: Develop a data hub to collaborate with country-level data centers to facilitate multiregional data workflow using the REDCap Harmonist platform and other tools; Research: catalyze TB, TB/HIV and TB/COVID-19 research within and across RePORT Country Networks, and with external partners; prioritize study of TB close contacts to evaluate biomarkers predictive of progression to TB across three “omics” platforms and three continents; Capacity Building: develop modular remote courses for capacity building in the components of TB research; Mentor early-stage investigator (ESI) development. TB-RICC 3.0 will deliver high-impact innovative research to advance TB Science and TB Control

TB-RICC 3.0旨在支持区域前瞻性观察研究结核病 (RePORT) 联盟将提供最高质量的观察和报告结核病 (TB)、TB-HIV 和 TB-COVID-19 的介入研究。目标，TB-RICC 3.0 将： i) 与 RePORT 国家网络数据中心合作，以及生物样本库确保通用协议的通用数据元素（CDE）和可通过全局数据模板访问样本跟踪 ii) 组织和/或加强参与诊断研究和临床试验的选定地点；以及 iii) 支持报告确保结核病诊断实验室、结核病诊断实验室进一步发展的国家网络 RICC 3.0 专业实验室和生物样本库 TB-RICC 3.0 的目标是：协调。中心结构和职能：建立领导小组和执行委员会；内部和外部有效沟通；建立数据中心，提供无缝数据；从收集到分析的管理；建立科学审查；委员会和行政核心；促进向潜在资助者提交赠款；数据协调：开发一个与国家级数据中心合作的数据中心。使用 REDCap Harmonist 平台和其他工具促进多区域数据工作流程；研究：促进报告国家内部和跨国家的结核病、结核病/艾滋病毒和结核病/COVID-19 研究网络并与外部合作伙伴合作；优先研究结核病密切接触者以评估生物标志物预测三个“组学”平台和三大洲的结核病进展；建设：开发模块化远程课程，用于结核病研究各部分的能力建设； Mentor 早期研究者 (ESI) 开发将带来高影响力。推动结核病科学和结核病控制的创新研究