Longitudinal Trajectories of Physical and Cognitive Function among Persons Aging with HIV

艾滋病毒感染者的身体和认知功能的纵向轨迹

• 批准号: 10263350
• 负责人: Mary Clare Masters
• 金额: $ 15.95万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263350
• 关键词: AIDS clinical trial group; Adult; Aging; Antidiabetic Drugs; Attenuated; Award; Caring; Clinical; Clinical Investigator; Clinical Trials; Cognition; Cohort Studies; Data; Development; Development Plans; Diabetes Mellitus; Elderly; Exercise; Exhibits; Female; Funding; Future; Gait speed; General Population; Glycosylated hemoglobin A; HIV; HIV Infections; Hand Strength; Hyperglycemia; Impaired cognition; Impairment; Incidence; Individual; Intervention; Investigation; Link; Longitudinal Studies; Measurement; Metformin; Mission; Morbidity - disease rate; Nature; Neurocognitive Deficit; Observational Study; Outcome; Participant; Persons; Pharmaceutical Preparations; Phenotype; Physical Function; Physical Performance; Physical activity; Population; Prediabetes syndrome; Proxy; Research; Research Personnel; Risk; The Multicenter AIDS Cohort Study; United States National Institutes of Health; Viral; Viremia; Woman; Women' s Interagency HIV Study; age related; anti aging; antiretroviral therapy; base; blood glucose regulation; career; cognitive function; cognitive performance; cohort; experience; frailty; functional decline; functional disability; functional status; glucose metabolism; immune function; improved; insight; interest; male; men; mortality; preservation; prevent; programs; prospective

PROJECT SUMMARY AND ABSTRACT Older persons with HIV (PWH) experience high rates of cognitive impairment and accelerated declines in function compared to the general population. These functional status declines have been associated with significant morbidity and mortality in among PWH. Among the elderly in the general y population, longitudinal dynamic relationships between physical and cognitive function have been identified. In PWH, cross-sectional associations between impaired cognition and physical function have been previously noted, but longitudinal trajectories of cognitive and physical function and how they are related have not been evaluated. Metformin has shown promise as a senolytic agent. Clinical trials are underway to investigate use of metformin in preventing age-related declines in among elderly adults without HIV. This proposal will investigate the longitudinal relationship between cognitive and physical function in PWH and assess the potential impact of metformin use on these trajectories. The proposed study will utilize data available from three large prospective, observational cohorts of men and women with or at risk for HIV. This investigation will be the first to comprehensively examine longitudinal associations between cognitive and physical function in a large group of PWH and assess the impact of metformin therapy on these outcomes among PWH. Our findings will inform the focus and ideal timing of interventions such as a formal interventional clinical trial of metformin use to prevent cognitive and physical function declines among older PWH. Moreover, this proposal aligns with the GEMSSTAR program’s mission to support a young investigator seeking to bridge aging and HIV research to improve care for older PWH.

项目概要和摘要 感染艾滋病毒的老年人 (PWH) 认知障碍发生率很高，并且认知能力加速下降 与一般人群相比，这些功能状态下降与 一般人群中老年人的发病率和死亡率显着，纵向。 在 PWH 中，已经确定了身体功能和认知功能之间的动态关系。 先前已注意到认知受损与身体功能之间的关联，但纵向 认知和身体功能的轨迹以及它们之间的关系尚未得到评估。 临床试验正在进行中，以研究二甲双胍在预防中的应用 未感染艾滋病毒的老年人中与年龄相关的下降 该提案将纵向调查。 感染者认知功能和身体功能之间的关系并评估二甲双胍使用的潜在影响 拟议的研究将利用来自三个大型前瞻性观察的数据。 这项调查将是首次对感染艾滋病毒或有感染艾滋病毒风险的男性和女性进行全面检查。 在一大群感染者中认知和身体功能之间的纵向关联并评估其影响 二甲双胍治疗对感染者的这些结果的影响我们的研究结果将告诉我们治疗的重点和理想时机。 干预措施，例如使用二甲双胍预防认知和身体疾病的正式干预临床试验 此外，该提案符合 GEMSSTAR 计划的使命： 支持一位年轻的研究人员寻求将老龄化和艾滋病毒研究联系起来，以改善对老年感染者的护理。