A prospective study of CFS following infectious mononucleosis in college students

大学生传染性单核细胞增多症CFS的前瞻性研究

• 批准号: 8968813
• 负责人: Leonard A Jason
• 金额: $ 73.54万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-01 至 2018-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8968813
• 关键词: Acute; Adolescent; Adrenergic Agents; Adult; Athletic Injuries; Autonomic Dysfunction; Autonomic nervous system; Baroreflex; Biological; Biological Factors; Blood Pressure; Childhood; Chronic Fatigue Syndrome; Clinic; Communicable Diseases; Coping Skills; Data; Development; Diagnosis; Diagnostic; Disease susceptibility; Enrollment; Event; Fatigue; Health; Health Services; Heart Rate; Human Herpesvirus 4; Individual; Infection; Infectious Mononucleosis; Inflammatory; Injury; Interferon Type II; Interleukin-2; Lead; Life; Military Personnel; Morbidity - disease rate; Motivation; Outcome; Participant; Patients; Performance; Peripheral Blood Mononuclear Cell; Phenotype; Population; Predisposing Factor; Prospective Studies; Psychological Factors; Recovery; Recruitment Activity; Research Design; Risk Factors; Sampling; Serum; Services; Severities; Severity of illness; Sorting - Cell Movement; Sports; Stress; Student Health Services; Students; Symptoms; Systemic infection; Therapeutic; Universities; Valsalva Maneuver; Virus Diseases; Visit; base; birth control; career; college; cytokine; high risk; longitudinal design; meetings; pediatric patients; peripheral blood; prospective; psychologic; psychological distress; undergraduate student; university student; young adult

DESCRIPTION (provided by applicant): About 12% of young adults will meet the criteria for chronic fatigue syndrome (CFS) 6 months following infectious mononucleosis (IM) (Katz et al., 2011). IM appears to be a predisposing factor for some individuals who develop CFS. Many candidate psychological and biological risk factors have been proposed to explain this phenomenon, but almost all lack prospective data from before the patients became ill with either IM or CFS. Some students develop IM while in college. Many student health services have students who use their services when they are medically well (e.g., for sports-related injuries and birth control). Our study will enroll Northwestern University (NU) students who use the university based health services when medically well, as well as after they develop IM and CFS. We will gather biological and psychological data when students are well, when they develop IM, and when they develop CFS. At the end of the 3 year recruitment period, we will continue to follow those who have developed CFS for 12 months. We will collect data regarding candidate biological and psychological factors thought to be related to the development of CFS, such as previous stressful life events, "action proneness", coping skills, autonomic dysfunction, cytokine levels and the severity of the IM itself. Our proposed study will compare these prospective pre-illness (IM) variables to post-illness (IM) data between students who do and do not go on to develop CFS. This study will be able to identify risk factors for the development of CFS following IM. We have the unique ability to implement this prospective study with a "captive" and high-risk population for the development of IM and CFS.

描述（由申请人提供）：大约 12% 的年轻人在传染性单核细胞增多症 (IM) 后 6 个月将达到慢性疲劳综合症 (CFS) 的标准（Katz 等人，2011 年）。 IM 似乎是一些患有 CFS 的个体的诱发因素。人们提出了许多候选的心理和生物危险因素来解释这种现象，但几乎所有因素都缺乏患者患 IM 或 CFS 之前的前瞻性数据。有些学生在大学期间就开发了 IM。许多学生健康服务的学生在身体状况良好时使用他们的服务（例如，与运动相关的伤害和节育）。我们的研究将招募西北大学 (NU) 的学生，他们在身体状况良好时以及患上 IM 和 CFS 后使用大学的医疗服务。当学生健康时、当他们出现 IM 时以及当他们出现 CFS 时，我们将收集生物和心理数据。在3年招募期结束时，我们将继续跟踪那些已经发展了CFS 12个月的人。我们将收集被认为与 CFS 发展相关的候选生物和心理因素的数据，例如以前的压力生活事件、“行动倾向”、应对技巧、自主神经功能障碍、细胞因子水平和 IM 本身的严重程度。我们提出的研究将比较发生和未发生 CFS 的学生之间的这些前瞻性病前 (IM) 变量和病后 (IM) 数据。这项研究将能够确定 IM 后发生 CFS 的风险因素。我们拥有独特的能力来实施这项针对 IM 和 CFS 发展的“圈养”高风险人群的前瞻性研究。