Viral Hepatitis C and Lipid Homeostasis

丙型肝炎病毒与脂质稳态

基本信息

批准号：
8997494
负责人：
ALEEM SIDDIQUI
金额：
$ 33.71万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-01-15 至 2017-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8997494
关键词：
Acetylation Affect Antioxidants Applications Grants Autophagocytosis Cells Chronic Hepatitis Chronic Hepatitis B Chronic Hepatitis C Crista ampullaris Development Drug Metabolic Detoxication Enzymes Event Excision Functional disorder Gene Expression Generations Health Hepatitis C Hepatitis C virus Hepatocyte Homeostasis Human Impairment Infection Inflammation Injury Investigation Lead Link Lipids Liver Liver Cirrhosis Liver diseases Maintenance Mediator of activation protein Metabolic Mitochondria Molecular Oxidative Stress Pathogenesis Patients Physiological Physiology Population Post-Translational Protein Processing Primary carcinoma of the liver cells Process Reactive Oxygen Species Reporting Risk Role Signal Transduction Stress Swelling Testing Up-Regulation Viral Viral hepatitis Virus Replication fatty acid oxidation insight lipid biosynthesis lipid metabolism liver injury liver transplantation mitochondrial dysfunction mitochondrial metabolism non-histone protein novel oxidation parkin gene/protein therapeutic target

项目摘要

DESCRIPTION (provided by applicant): Hepatitis C virus infections most often lead to chronic hepatitis, which can progress to liver cirrhosis and hepatocellular carcinoma. The infection is also associated with steatosis. HCV alters lipid homeostasis. HCV stimulates lipogenesis, impairs mitochondrial ¿-oxidation and lipid export. These altered lipid metabolic activities benefi viral infectious process. Several lipid molecules affect viral replication, assembly, maturation and secretion. In this resubmission of our application, we continue to investigate molecular mechanism(s) associated with HCV-induced alteration of host lipid metabolism. Our current focus will be on effect of HCV gene expression on mitochondrial ¿-oxidation and the mitochondrial dysfunctions associated with chronic hepatitis C. We propose to investigate the effects of HCV gene expression on mitochondrial enzymes involved in lipid metabolism, and mechanisms of clearance of damaged mitochondria via mitophagy. These studies provide a unique insight and open avenues of investigations into HCV-associated liver disease pathogenesis

描述（由申请人提供）：丙型肝炎病毒感染最常导致慢性肝炎，进而发展为肝硬化和肝细胞癌。HCV 感染还与脂肪变性有关，HCV 会刺激脂肪生成。 -氧化和脂质输出。这些改变的脂质代谢活动有利于病毒感染过程。在我们重新提交的申请中，我们继续研究与 HCV 诱导相关的分子机制。我们目前的重点是 HCV 基因表达对线粒体的影响。 -与慢性丙型肝炎相关的氧化和线粒体功能障碍。我们建议研究 HCV 基因表达对参与脂质代谢的线粒体酶的影响，以及通过线粒体自噬清除受损线粒体的机制。 HCV相关肝病发病机制的研究