Training in the Molecular Basis of Skin/Mucosa Pathobiology

皮肤/粘膜病理学分子基础培训

• 批准号: 9116807
• 负责人: MOLLY F. KULESZ-MARTIN
• 金额: $ 25.16万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9116807
• 关键词: Molecular; Mucous Membrane; Skin; Training; base; Molecular; Mucous Membrane; Skin; Training; base

DESCRIPTION (provided by applicant): The OHSU Department of Dermatology proposes continuation of its 10-year "Training in the Molecular Basis of Skin/Mucosa Pathobiology" program, with the objective of preparing highly qualified pre-doctoral and postdoctoral researchers for academic careers that lead to better understanding and treatment of skin, oral and intestinal cancers. Currently the only NCI-funded training program at OHSU, our program focuses on cancers that are accessible from their earliest stages, and thus ideal for understanding multi-step carcinogenesis, testing prevention strategies, and targeting and monitoring success of treatments. Specifically, we aim: 1. to engage trainees in furthering an understanding of the molecular pathways that underlie skin/mucosa disease, in evolving and using specialized approaches to advance the field, and in providing insight and ultimately applications to clinical problems~ and 2. to foster interactions among mentor/trainee laboratories that enrich the dermatology field and increase its scope and impact on understanding and treating cancer and inflammatory disease. The program offers internationally recognized faculty researchers from dermatology, 6 basic science departments and 5 OHSU institutes and centers, who are dedicated to training the next generation and collaborating to form a focus on carcinogenesis, diagnostics, prevention and treatment of cancer and inflammatory disease. The program engages trainees and mentors in sharing of ideas and specialized resources (keratinocyte- and melanocyte-targeted inducible genetic models of skin, colon and head and neck cancer and inflammatory disease~ non-invasive optical imaging~ specialized cell isolation of epithelial and immun populations~ the Molecular Profiling Resource containing freshly cryopreserved human tumor and normal mucosa and skin specimens and primary skin and oral tumor cultures), and exposes trainees to translation of basic science to clinical treatment through program-specific curriculum. These include monthly Joint Lab meeting for research presentations by trainees and dermatology research laboratories as well as outside speakers selected by trainees~ the forums "Translational Topics" and High Impact Translational (HIT) journal club that feature joint presentations of residents and scientists~ mandatory advisory committee meetings~ and didactic, career development and responsible conduct of research training. The scientific scope includes homeostatic and oncogenic mechanisms (c-Myc, Ras and B-Raf, IGFs, Trim32, Wnt, EGFR, RXR, CTIP, CDKN2A/p16, MC1R, cytokines and their receptors) of tumor, endothelial, immune and other stromal cell cross talk and role of matrix and secreted factors. Two predoctoral and 3 postdoctoral MD, PhD or MD/PhD candidates are appointed each year, selected for aptitude, special experience to offer the field, desire to incorporate a strong translational component and potential for impact on investigative dermatology in skin/mucosa cancer and inflammation.

描述（由申请人提供）：OHSU皮肤病学系提议继续其10年的“在皮肤/粘膜病理生物学的分子基础上培训”计划，目的是准备高素质的学术前和博士后研究人员对学术职业的研究，以更好地了解皮肤，口腔和肠道癌。目前，OHSU是NCI资助的培训计划，我们的计划着重于可以从最早阶段进入的癌症，因此非常适合理解多步癌发生，测试预防策略以及靶向和监测治疗的成功。具体而言，我们的目的是：1。吸引受训者进一步了解皮肤/粘膜疾病的分子途径，在不断发展和使用专门的方法方面发展和使用专门的方法来推进该领域，并在临床问题上提供洞察力和最终应用于临床问题和2。以促进培养癌症和疾病疾病的疾病和对癌症的疾病的互动，并在癌症中促进癌症，并影响了癌症和疾病。该计划提供了来自皮肤病学，6个基础科学部门和5个OHSU机构和中心的国际认可的教师研究人员，他们致力于培训下一代，并合作着重于致癌，诊断，预防和治疗癌症和炎症性疾病。 该计划使学员和指导者共享思想和专业资源（角质形成细胞和黑素细胞靶向的皮肤，结肠和头颈癌的诱导遗传模型以及炎症性疾病以及炎症性疾病〜非侵入性光学成像〜非侵入性光学成像。口服肿瘤培养物），并通过计划特定的课程使学员将基础科学转化为临床治疗。 其中包括由学员和皮肤病学研究实验室以及受训者选出的外部演讲者的每月联合实验室会议〜论坛“转化主题”和高影响力翻译（HIT）期刊俱乐部，其中包含居民和科学家的共同介绍〜强制性咨询委员会会议〜和教义，职业发展，职业发展和负责研究培训。科学范围包括稳态和致癌机制（C-MYC，RAS和B-RAF，IGFS，TRIM32，WNT，WNT，EGFR，EGFR，RXR，CTIP，CTKN2A/P16，MC1R，MC1R，细胞因子，受体及其受体），肿瘤，内皮层，免疫细胞和其他层型细胞交叉和Mat tallix and Mater and Matrix and Come and Mate and tartrix和其他角色。 每年任命两名毒性和3个博士后MD，博士学位或MD/PhD候选人 成分和影响皮肤/粘膜癌和炎症的调查性皮肤病学的潜力。