MDIBL Symposium on Stem Cells and Aging

MDIBL干细胞与衰老研讨会

• 批准号: 10237394
• 负责人: IAIN A. DRUMMOND
• 金额: $ 2.5万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10237394
• 关键词: Address; Age; Aging; Animals; Area; Atmosphere; Biological; Blood Cells; Brain; Caloric Restriction; Cell Communication; Cells; Cellular Metabolic Process; Collaborations; Communities; DNA Damage; Discipline; Engineering; Epigenetic Process; Equilibrium; Faculty; Failure; Fishes; Generations; Genetic Transcription; Human; Immersion; Inflammation; Inflammatory; Injury; Island; Knowledge; Laboratories; Longevity; Lung; Maine; Maintenance; Medical center; Mus; Muscle; Mutation; Organ; Organ failure; Outcome; Pathology; Postdoctoral Fellow; Regenerative research; Rejuvenation; Research; Research Institute; Research Personnel; Scientific Advances and Accomplishments; Scientist; Series; Signal Transduction; Skin; Stem Cell Research; System; The Jackson Laboratory; Tissues; Training; aged; base; career; comparative; fly; graduate student; innovation; meetings; novel strategies; posters; programs; regenerative biology; research study; stem cell aging; stem cell niche; stem cell self renewal; stem cells; symposium; tissue regeneration; tissue stem cells

Abstract The Mount Desert Island Biological Laboratory (MDIBL), in collaboration with The Jackson Laboratory, and the Maine Medical Center Research Institute, proposes a conference series on "Stem Cells and Aging" to be held annually in July of 2020, 2021, and 2022 at MDIBL with the support of the NIA. This conference builds on a strong tradition of stem cell conferences at MDIBL that were first offered in 2002. The proposed series for 2020- 2022 will focus on stem cells and aging, addressing questions related to the causes of aging-associated failure of stem cell quiescence and activation, the impact of stem cell-extrinsic versus stem cell-intrinsic mechanisms in aging associated dysregulation, and new approaches to delay aging by stabilizing stem cell quiescence or reducing stem cell vulnerability. This conference will be followed by a two-week course at MDIBL "iCARB: Immersion in Comparative Aging and Regenerative Biology" that trains graduate students, postdoctoral fellows, and career scientists to become leaders in Aging and Regeneration research. The Organizing Committee, made up of national leaders in biomedical and stem cell research, has developed the program of this symposium to address current issues important to both the stem cell and aging research communities. The specific aims of the 2020 symposium are: 1) Present and discuss research studies of aging related pathologies that impact stem cells and regeneration including DNA damage / mutation, inflammation, altered cell metabolism / ROS generation, and aging-related changes in stem cell quiescence; 2) Present and discuss scientific advances defining cell-intrinsic and -extrinsic mechanisms governing stem cell aging including transcriptional programs, epigenetic programs, niche cell communication, and niche composition; 3) Present and discuss research on comparative aspects of aging (human, mouse, fish, worm, fly) with a focus on broadly conserved cellular changes in aging; 4) Present and discuss research on promoting stem cell-based tissue regeneration and rejuvenation in aging including studies of caloric restriction and stem cells, inflammatory signaling in aged stem cells, and niche engineering; and 5) Provide extensive opportunities for interaction between trainees, investigators new to stem cell research, and investigators well established in these research areas. Scientific sessions will include platform presentations, poster sessions, and a trainee/faculty networking lunch.

抽象的 山漠岛生物实验室 (MDIBL) 与杰克逊实验室合作，以及 缅因州医学中心研究所提议举办“干细胞与衰老”系列会议 在 NIA 的支持下，每年 2020 年 7 月、2021 年和 2022 年在 MDIBL 举办。本次会议建立在 MDIBL 干细胞会议于 2002 年首次举办，具有悠久的传统。2020 年拟议的系列会议- 2022 年将重点关注干细胞和衰老，解决与衰老相关的失败原因相关的问题 干细胞静止和激活的影响，干细胞外在机制与干细胞内在机制的影响 衰老相关的失调，以及通过稳定干细胞静止或延迟衰老的新方法 减少干细胞的脆弱性。本次会议之后将在 MDIBL 举办为期两周的课程“iCARB： 沉浸在比较衰老和再生生物学中”培训研究生、博士后研究员、 和职业科学家成为衰老和再生研究的领导者。组委会制定了 由生物医学和干细胞研究领域的国家领导人组成，制定了本次研讨会的议程 解决当前对干细胞和衰老研究界重要的问题。该计划的具体目标 2020 年研讨会的内容是： 1) 展示并讨论影响干细胞的衰老相关病理学的研究 细胞和再生，包括 DNA 损伤/突变、炎症、细胞代谢改变/ROS 干细胞静止的产生和衰老相关变化； 2) 展示并讨论科学进展 定义控制干细胞衰老的细胞内在和外在机制，包括转录程序， 表观遗传程序、生态位细胞通讯和生态位组成； 3) 展示并讨论相关研究 衰老的比较方面（人类、小鼠、鱼、蠕虫、苍蝇），重点关注广泛保守的细胞变化 在老化中； 4) 介绍并讨论促进基于干细胞的组织再生和年轻化的研究 衰老，包括热量限制和干细胞、衰老干细胞中的炎症信号传导和生态位的研究 工程; 5) 为受训者、新干研究人员之间的互动提供广泛的机会 细胞研究，以及在这些研究领域颇有建树的研究人员。科学会议将包括平台 演示、海报会议和实习生/教员交流午餐。