Transient Lighting for Fluorescence Image-Guided Surgery

用于荧光图像引导手术的瞬态照明

• 批准号: 9202254
• 负责人: Adam John Uselmann
• 金额: $ 30万
• 依托单位: ONLUME, LLC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-21 至 2017-07-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9202254
• 关键词: Address; Adoption; Affect; Aminolevulinic Acid; Animal Experimentation; Animal Model; Animals; Boxing; Cancer Model; Clinical; Collaborations; Collection; Darkness; Detection; Development; Effectiveness; Environment; Excision; Eye; Fluorescein; Fluorescence; Fluorescent Probes; Frequencies; Goals; Gold; Guidelines; Human; Image; Image-Guided Surgery; Imagery; Imaging Device; Imaging technology; Laboratory Research; Light; Lighting; Measurement; Methods; Noise; Operating Rooms; Operative Surgical Procedures; Optics; Patients; Performance; Phase; Photons; Physiologic pulse; Public Health; Research; Research Institute; Signal Transduction; Speed; System; Techniques; Testing; Time; Tissues; Validation; Work; abstracting; animal imaging; base; cancer surgery; clinical application; commercialization; design; ergonomics; fluorescence imaging; fluorescence microscope; imaging system; in vivo; malignant breast neoplasm; meetings; mouse model; prototype; seal; software development; standard of care; tumor

Abstract We will develop a fluorescence image guided surgery (FIGS) system that delivers optimum, background-free performance without the need to turn off or lower room lighting. Fluorescence image-guided surgery (FIGS) is a rapidly evolving field with broad clinical applications, including more efficacious removal of tumors in real-time; however, ambient room lighting contaminates the fluorescence signal emitted from the patient during the surgical procedure. We are applying a new method called transient lighting that utilizes high-power - low duty cycle switched white LEDs for room and surgical field illumination allowing for timed fluorescence capture that is not affected by the room lights. As part of this project OnLume, Inc. will design and test a prototype system for surgical applications.

抽象的 我们将开发一种荧光图像引导手术 (FIGS) 系统，该系统可提供 无需关闭或降低房间照明即可获得最佳的无背景性能。 荧光图像引导手术 (FIGS) 是一个快速发展的领域，具有广泛的临床应用前景 应用，包括更有效地实时切除肿瘤；然而，环境房间 照明污染了手术期间患者发出的荧光信号 程序。我们正在应用一种称为瞬态照明的新方法，该方法利用高功率-低功率 用于房间和手术区域照明的占空比切换白光 LED 允许定时 不受室内灯光影响的荧光捕获。作为该项目的一部分 OnLume, Inc. 将设计和测试用于外科应用的原型系统。