P30 Center Core Grant for Vision Research

P30 中心视觉研究核心资助

• 批准号: 10272007
• 负责人: Darren James Lee
• 金额: $ 9.18万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10272007
• 关键词: Cells; Center Core Grants; Computer software; Data; Data Analyses; Disease model; Environment; Equipment; Eye; Flow Cytometry; Funding; Grant; Guidelines; Health Sciences; Hour; Human Resources; Image; Immunoassay; Immunobiology; Infection; Inflammation; Institutes; Laboratories; Lasers; Molecular; Oklahoma; Pathogenesis; Publications; Reader; Research; Research Personnel; Sampling; Savings; Scientist; Services; Suspensions; System; Therapeutic; Training; Universities; Vision; Vision research; cell type; experimental study; innovation; instrumentation; model development; novel; ranpirnase; synthetic polymer Bioplex; user-friendly; vision development

ABSTRACT Ocular Immunobiology Core Vision research requires the identification and quantification of cell types and their effector molecules to investigate the mechanisms of visual development and degeneration, the pathogenesis of blinding infection and inflammation, and the efficacy of vision-saving therapeutics. The new Ocular Immunobiology Core (OIC) at the University of Oklahoma Health Sciences Center is responsible for providing vision researchers with state-of-the-art instrumentation for examining single cells involved in vision models of development, degeneration, infection, and inflammation at the cellular and molecular levels. This Core supports vision research on 16 NEI-funded R01 grants and other vision-related projects at OUHSC, and is located in the Dean McGee Eye Institute. We anticipate more than 40 ocular disease models to be analyzed by the Cytek Aurora and BioPlex 200 Multiplex Suspension Array. Our Systems Analyst is highly skilled in training personnel, assisting with experiments and data analysis, and maintaining core equipment to a quality standard. As such, the OIC provides instrumentation and expertise that is at the forefront of flow cytometry. Importantly, we plan to continue to expand this core to remain ahead of the curve allowing vision researchers to continue to be competitive and maintain a high quality of research. This novel and innovative Core is motivated and committed to providing an effective, efficient, user-friendly, and high-quality research environment for all vision researchers at OUHSC.

抽象的 眼部免疫生物学核心 视觉研究需要识别和量化细胞类型及其效应分子 研究视觉发育和退化的机制、致盲感染的发病机制 和炎症，以及挽救视力疗法的功效。新的眼部免疫生物学核心 (OIC) 俄克拉荷马大学健康科学中心负责为视觉研究人员提供 用于检查视觉发育模型中涉及的单细胞的最先进的仪器， 细胞和分子水平上的变性、感染和炎症。该核心支持愿景 OUHSC 的 16 个 NEI 资助的 R01 资助项目和其他与视觉相关的项目的研究，位于院长办公室 麦吉眼科研究所。我们预计 Cytek Aurora 将分析 40 多种眼部疾病模型 和 BioPlex 200 多重悬浮阵列。我们的系统分析师在培训人员方面非常熟练， 协助实验和数据分析，并使核心设备保持质量标准。像这样， OIC 提供流式细胞术最前沿的仪器和专业知识。重要的是，我们计划 继续扩展这一核心以保持领先地位，使视觉研究人员能够继续 竞争力并保持高质量的研究。这个新颖且创新的核心是有动力和 致力于为所有视力者提供有效、高效、人性化、高质量的研究环境 OUHSC 的研究人员。