Clinical Translation and Validation Core

临床转化和验证核心

• 批准号: 10274374
• 负责人: Rama Chellappa
• 金额: $ 12.3万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10274374
• 关键词: Advanced Development; Advertising; Aging; Ambulatory Care; Area; Artificial Intelligence; Caring; Clinic; Clinical; Clinical Engineering; Clinical Research; Cognition; Cognitive; Collaborations; Communities; Consent; Consultations; Data; Data Analyses; Data Collection; Dementia; Development; Development Plans; Devices; Documentation; Elderly; Ensure; Future; Geriatrics; Goals; Health Technology; Home; Human Subject Research; Impaired cognition; Institutes; Institutional Review Boards; Intervention; Laboratories; Leadership; Long-Term Care; Maintenance; Measurement; Medical center; Mentorship; Methods; Minority Recruitment; Monitor; Nursing Homes; Outcome; Performance; Physical Function; Pilot Projects; Preparation; Primary Health Care; Procedures; Registries; Research; Research Design; Research Personnel; Resources; Safety; Scientist; Site; Technology; Testing; Training; Translational Research; Translations; Trust; Universities; Validation; Work; base; clinical translation; collaboratory; design; experience; feasibility testing; frailty; human subject; human subject protection; innovation; intelligent algorithm; interest; programs; protocol development; prototype; recruit; resilience; synergism; technology development

The Johns Hopkins University (JHU) Artificial Intelligence (Al) and Technology Collaboratory (AITC) proposes a Clinical Translation and Validation Core that aims to cultivate and support cutting edge Al prototype testing and exploratory studies that are needed to develop crucial larger scale and confirmatory pilots in order to advance the development of effective Al technologies to facilitate independence in older adults. This core is designed to serve as a hub and a clinical laboratory for innovators to validate prototypes and undertake rigorous feasibility testing for the Al algorithms and technology devices in clinical and "real-world" settings. The specific aims of the Clinical Translation and Validation Core are 1) To provide state-of-the-art scientific (Clinical and Engineering) expertise and work with the administrative core to facilitate soliciting proposals and identifying and selecting Al approaches or technologies to be clinically validated in the Collaboratory or our partner sites; 2) To develop and maintain a research registry with emerging Al approaches or technologies to be validated in clinics and identify clinical researchers (and their clinical studies) and other stakeholders interested in validating Al algorithms or technologies in their clinics or other real-world settings; 3) To provide the AITC investigators identified in aim 1, with mentorship and training in all aspects of human subjects' research, including study conceptualization, study design and outcomes, definition of interventions, measurement, data analysis, protocol development and implementation, regulatory approval, quality assessment, and standard operating procedures related to aging, dementia and the maintenance of independence; 4) to provide intellectual leadership necessary to identify and match Al researchers with clinical research investigators that are best suited to successfully validate prototypes and undertake rigorous feasibility testing for the artificial intelligence algorithms and technology devices in both clinical and "real-world" settings; and 5) to facilitate the transition of successful prototypes into clinical studies in collaboration with the leadership of the Pilot Cores (Aging and AD) as well as all other cores. To achieve these goals, the core is led by an Al and technology development experienced investigator partnered with a Geriatrics Clinician Scientist with expertise in translational research focused on physical and cognitive decline in older adults. This balanced leadership will facilitate the development, implementation, and conduct of prototype development and testing in this core. A highly skilled and experienced research program manager with expertise in minority recruitment and the measurement of frailty and mobility will facilitate the completion of these aims. These aims will be carried out in collaboration with the leaders of all other cores. Additional resources are provided by the JHU Institute of Clinical and Translational Research, which will help to ensure optimal study design, implementation, measurement, and interpretation of results, and Fast Forward, a translationally-focused unit at JHU, will facilitate health technology development that focuses on using Al to maximize independence in older adults.

约翰·霍普金斯大学 (JHU) 人工智能 (Al) 和技术合作实验室 (AITC) 提出 旨在培养和支持尖端人工智能原型测试的临床转化和验证核心 以及开发关键的更大规模和验证性试点所需的探索性研究，以便 推进有效的人工智能技术的开发，以促进老年人的独立。这个核心是 旨在作为创新者验证原型并开展研究的中心和临床实验室 在临床和“现实世界”环境中对人工智能算法和技术设备进行严格的可行性测试。这 临床转化和验证核心的具体目标是 1) 提供最先进的科学（临床） 和工程）的专业知识，并与行政核心合作，以促进征求建议和 识别和选择在合作实验室或我们的实验室中进行临床验证的人工智能方法或技术 合作伙伴网站； 2）利用新兴的人工智能方法或技术开发和维护研究登记册 在诊所进行验证并确定临床研究人员（及其临床研究）和其他利益相关者 有兴趣在诊所或其他现实环境中验证人工智能算法或技术； 3) 提供 AITC 研究人员在目标 1 中确定，在人类受试者的各个方面进行指导和培训 研究，包括研究概念化、研究设计和结果、干预措施的定义、 测量、数据分析、方案开发和实施、监管审批、质量 与衰老、痴呆和维持相关的评估和标准操作程序 独立; 4）提供必要的智力领导，以识别人工智能研究人员并将其与临床 最适合成功验证原型并进行严格可行性研究的研究人员 在临床和“现实世界”环境中测试人工智能算法和技术设备； 5) 与 领导核心（老化和AD）以及所有其他核心。实现这些目标，核心是引领 由一位经验丰富的人工智能和技术开发研究人员与一位老年病学临床科学家合作 拥有专注于老年人身体和认知衰退的转化研究方面的专业知识。这个平衡 领导层将促进原型开发和测试的开发、实施和进行 这个核心。技术精湛、经验丰富的研究项目经理，拥有少数族裔招聘方面的专业知识 对虚弱和活动能力的测量将有助于实现这些目标。这些目标将是 与所有其他核心的领导人合作进行。 JHU 提供额外资源 临床和转化研究所，这将有助于确保最佳的研究设计、实施、 测量和结果解释，以及 JHU 的一个专注于翻译的单位 Fast Forward，将 促进健康技术的发展，重点是利用人工智能最大限度地提高老年人的独立性。