A personalized approach to skin cancer prevention among adolescents

青少年皮肤癌预防的个性化方法

基本信息

批准号：
10589066
负责人：
Yelena Ping Wu
金额：
$ 58.42万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10589066
关键词：
Active Learning Address Adolescent Behavior Caucasians Cells Child Childhood Cluster randomized trial Data Dermatology Diagnosis Disease Drug abuse Education Environmental Risk Factor Exposure to Face Female Funding Future Geography Goals Habits Health Health behavior change Health education Incidence Individual Intervention Intervention Studies Investigation Malignant Neoplasms Measures Mediating Mediation Modeling National Cancer Institute Outcome Parents Patient Self-Report Persons Population Predisposition Prevention program Prevention strategy Preventive Process Protective Clothing Quasi-experiment Questionnaires Radiation induced damage Reporting Research Risk Sampling Schools Seasons Self Efficacy Skin Skin Cancer Skin tanning Smoking Students Subgroup Sunburn Sunscreening Agents Testing Time Treatment Cost Treatment Efficacy UV Radiation Exposure Ultraviolet Rays Underserved Population United States National Institutes of Health academic standard adolescent health arm cancer education design efficacy evaluation efficacy testing elementary school follow-up high school improved interest intervention effect melanoma monitoring device multi-component intervention ninth grade novel personalized approach personalized intervention personalized learning post intervention prevent preventive intervention primary outcome programs randomized trial recruit secondary outcome sex skin cancer prevention sun protection teacher tenth grade ultraviolet damage

项目摘要

PROJECT SUMMARY Adolescents urgently need efficacious skin cancer preventive interventions due to their poor use of sun protection and likelihood to tan intentionally. Schools offer the ideal setting for delivering skin cancer preventive interventions to large numbers of adolescents. Existing efficacious school skin cancer preventive interventions target young children (elementary school students), use a one-size-fits-all approach, and focus on either sun protection or tanning but not both. We designed a novel and personalized skin cancer preventive intervention for adolescents that is delivered in the school setting and includes complementary content delivered to parents and teachers. This multi-modal intervention builds on adolescents’ interest in novelty and need for highly personalized interventions. In our preliminary study of the intervention components with 1,573 students in 11 schools, we observed medium to large effects for sun protection behaviors and small to medium effects for tanning and sunburn, with increased adolescent sun protection and better control in intentional tanning and sunburn pre- to post-intervention. We propose a two-arm, cluster randomized trial to test the efficacy of the intervention we developed against standard education among 30 schools (10,250 students total). The in-class intervention sessions will be delivered through health education classes. The co-primary outcomes of the trial will be adolescent sun protection use and intentional tanning assessed via self-report questionnaire pre- intervention and at three follow-up timepoints through one year post-intervention. Secondary outcomes include objectively assessed ultraviolet radiation exposure and sunburn occurrence. Assessment timepoints will be seasonally timed and ambient UVR will be included as a covariate. We will also identify the mechanisms by which the intervention impacts adolescent sun protection use and intentional tanning. Through this project, we will also examine moderators of the intervention effects on sun protection and tanning outcomes in order to guide future tailoring of the intervention to maximize efficacy for potentially underserved groups. This project addresses the critical need for school-based skin cancer preventive interventions that both increase adolescent use of sun protection and decrease intentional tanning. The project will also lead to new scientific understanding of the theoretical mechanisms underlying intervention outcomes and moderators of the intervention effects, which will inform future tailoring of the intervention to better meet the needs of particular subgroups.

项目概要由于青少年日晒不良，他们迫切需要有效的皮肤癌预防干预措施保护和有意晒黑的可能性学校为预防皮肤癌提供了理想的环境。对大量青少年进行现有有效的学校皮肤癌预防干预措施。针对幼儿（小学生），采用一刀切的方法，重点关注任一太阳我们设计了一种新颖且个性化的皮肤癌预防干预措施。针对青少年，在学校环境中提供，并包括向家长提供的补充内容这种多模式干预建立在青少年对新奇事物的兴趣和高度需求的基础上。在我们对 11 个地区的 1,573 名学生进行的干预组成部分的初步研究中。在学校中，我们观察到对防晒行为的中到大影响以及对防晒行为的中小影响晒黑和晒伤，增加青少年防晒并更好地控制有意晒黑和晒伤我们提出了一项两组随机试验来测试干预前后的晒伤效果。我们针对 30 所学校（总共 10,250 名学生）的标准教育制定了干预措施。干预课程将通过健康教育课程进行。试验的共同主要结果。将通过自我报告问卷预先评估青少年防晒霜的使用和有意晒黑的情况干预期间以及干预后一年内的三个随访时间点的次要结果包括。客观评估紫外线照射和晒伤发生情况的评估时间点。季节性时间和环境 UVR 将作为协变量包括在内，我们还将通过以下方式确定其机制。通过这个项目，我们的干预措施影响了青少年防晒的使用和有意晒黑。还将检查对防晒和晒黑结果的干预效果的调节因素，以便指导未来干预措施的调整，以最大限度地提高潜在服务不足群体的功效。满足了以学校为基础的皮肤癌预防干预措施的迫切需求，这些干预措施既增加了青少年使用防晒和减少故意晒黑该项目还将带来新的科学成果。了解干预结果背后的理论机制和调节因素干预效果，这将为未来调整干预措施提供信息，以更好地满足特定群体的需求亚组。