Assessing the feasibility and acceptability of a Time Restricted Feeding intervention among older adults with Mild Cognitive Impairment

评估对患有轻度认知障碍的老年人进行限制时间喂养干预的可行性和可接受性

• 批准号: 10583672
• 负责人: Patrick Josey Smith
• 金额: $ 52.8万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583672
• 关键词: Acute; Address; Adherence; Adult; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Animals; Behavioral; Brain; Caloric Restriction; Carbohydrates; Cerebrum; Clinical; Cognition; Cognitive; Collection; Complex; Consumption; Diet Modification; Dietary Practices; Eating; Elderly; Energy Supply; Energy-Generating Resources; Enrollment; Fasting; Feasibility Studies; Future; Geriatrics; Glucose; Glycosylated hemoglobin A; Goals; Hour; Human; Impaired cognition; Impairment; Incidence; Individual; Insulin; Intervention; Ketones; Kynurenic Acid; Link; Measures; Memory; Metabolic; Metabolic Marker; Metabolic dysfunction; Metabolic stress; Metabolic syndrome; Metabolism; Molecular; Obesity; Organ; Participant; Pattern; Physiology; Pilot Projects; Procedures; Protocols documentation; Qualifying; Randomized; Reporting; Research Personnel; Resources; Risk; Risk Factors; Risk Reduction; Sampling; Somatomedins; Source; Time; Time-restricted feeding; Tryptophan; United States; Variant; Work; acceptability and feasibility; acylcarnitine; adult obesity; arm; beta-Hydroxybutyrate; cognitive enhancement; cognitive function; cognitive performance; cognitive testing; comorbidity; dietary; executive function; fatty acid oxidation; flexibility; glucose metabolism; high risk; improved; ketogenic diet; lifestyle intervention; mild cognitive impairment; novel; portability; post intervention; preservation; satisfaction; standard measure

Obesity and related metabolic comorbidities have been associated with more than a 4-fold increased risk of incident cognitive impairment, including Alzheimer’s disease and related dementias (ADRD). Dysfunctional metabolic flexibility is increasingly recognized as a critical mechanism linking metabolic risk factors to risk of cognitive impairment, although few studies portable behavioral strategies to enhance metabolic function among individuals at risk for ADRD. The present study will examine the feasibility and acceptability of a 12-week time restricted feeding intervention among individuals with mild cognitive impairment (MCI). Changes in cognitive and metabolic function will also be examined.

肥胖和相关代谢合并症与 4 倍以上的风险增加有关 偶发性认知障碍，包括阿尔茨海默病和相关痴呆症 (ADRD)。 代谢灵活性越来越被认为是连接代谢危险因素与风险的关键机制 尽管很少有人研究便携式行为策略来增强代谢功能 本研究将探讨 12 周时间的可行性和可接受性。 对患有轻度认知障碍（MCI）的个体进行限制性喂养干预。 还将检查代谢功能。