Edited Magnetic Resonance Spectroscopy of the Pediatric Brain

儿科大脑磁共振波谱编辑

• 批准号: 10583752
• 负责人: Richard Anthony Edward Edden
• 金额: $ 73.21万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583752
• 关键词: Address; Adult; Age; Algorithm Design; Algorithms; Aspartate; Atlases; Benchmarking; Brain; Brain Chemistry; Child; Child Development; Childhood; Choline; Clinical; Data; Development; Functional disorder; General Anesthesia; Genetic; Glutamates; Glutamine; Glutathione; Goals; Grant; Human; Infant; Knowledge; Life; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Membrane Lipids; Metabolic; Methods; Mitochondria; Modeling; Morphologic artifacts; Motion; N-acetylaspartylglutamate; Napping; Neuromodulator; Neurotransmitters; Oxidation-Reduction; Oxidative Stress; Pediatric cohort; Pediatrics; Relaxation; Resolution; Risk Factors; Scanning; Scheme; Signal Transduction; Site; Sleep; Techniques; Time; Vendor; Water; anaerobic glycolysis; ascorbate; awake; computerized data processing; early childhood; experimental study; gamma-Aminobutyric Acid; improved; in vivo; infancy; innovation; interest; method development; myelination; myoinositol; neurochemistry; neurodevelopment; phosphoethanolamine; spatiotemporal; tool; working group

Summary Human neurochemistry undergoes dramatic changes in early childhood, due to the rapid pace of development. However, techniques for assessing neurochemistry non-invasively by magnetic resonance spectroscopy (MRS) in young children are limited. Spectral editing is the gold-standard for detecting MRS signals from key neurometabolites such as the neurotransmitters glutamate (Glu) and GABA, the neuromodulators N-acetyl aspartyl glutamate (NAAG) and aspartate (Asp), the redox compounds glutathione (GSH) and ascorbate (Asc), the anaerobic glycolysis product lactate (Lac), and the membrane lipid precursor phosphorylethanolamine (PE). Measurement of these lower-concentration metabolites is vital for investigating healthy and disrupted neurodevelopment, including inhibitory dysfunction, oxidative stress, myelination and mitochondrial metabolic disruption. To date, spectral editing has not been applied at large in pediatrics – arguably the arena in which they will be leveraged most powerfully for scientific discovery and clinical value. This project will develop acquisition and analysis tools for multi-metabolite MRS in the pediatric brain, focusing on developing motion-robust acquisitions. It will also acquire reference data for the best-practice analysis of pediatric spectra, including the macromolecular background spectrum and metabolite relaxometry. This project will have a key push-pull interaction with the HEALthy Brain & Child Development (HBCD) Study, a 25-site national study of neurodevelopmental risk factors (including four sites in this proposal). HBCD applies the acquisition and analysis methods developed by PI Edden's group (HERCULES and Osprey), and Drs. Edden and Wisnowski are co-chairs of the HBCD MRS working group. Dissemination of methods from this project will directly support HBCD, and this new focus on methods development for pediatric cohorts will allow us to directly address technical issues as they arise in HBCD. Data acquired during HBCD will supplement the data acquired in this grant as we develop a profound new understanding of the neurometabolic trajectory of early childhood.

概括 由于快速发展，人类神经化学在幼儿期经历了巨大的变化 然而，通过磁共振非侵入性评估神经化学的技术正在发展。 幼儿的光谱 (MRS) 检测是有限的。光谱编辑是检测 MRS 的黄金标准。 来自关键神经代谢物的信号，例如神经递质谷氨酸 (Glu) 和 GABA 神经调节剂 N-乙酰天冬氨酰谷氨酸 (NAAG) 和天冬氨酸 (Asp)，氧化还原化合物谷胱甘肽 (GSH) 和抗坏血酸 (Asc)、无氧糖酵解产物乳酸 (Lac) 和膜脂前体 磷酸乙醇胺 (PE) 的测量对于研究至关重要。 健康和受损的神经发育，包括抑制功能障碍、氧化应激、髓鞘形成和 线粒体代谢紊乱。 迄今为止，光谱编辑尚未在儿科领域广泛应用——可以说，这是他们将要应用的领域。 该项目将最有力地利用科学发现和临床价值。 儿科多代谢物 MRS 和分析工具，重点开发运动鲁棒性 它还将获取儿科光谱最佳实践分析的参考数据，包括 大分子背景光谱和代谢物弛豫测定。 该项目将与健康大脑和儿童发展（HBCD）进行关键的推拉互动 这项研究是一项全国 25 个地点的神经发育危险因素研究（包括本研究中的 4 个地点） HBCD 采用 PI Edden 小组开发的采集和分析方法。 （HERCULES 和 Osprey），Edden 和 Wisnowski 博士是 HBCD MRS 的联合主席 该项目的方法传播将直接支持六溴环十二烷，这一新的重点是 儿科队列的方法开发将使我们能够直接解决技术问题 HBCD 期间获得的数据将补充我们在本次拨款中获得的数据。 对幼儿期的神经代谢轨迹形成深刻的新理解。