A Novel Spray-On Sensing Platform Technology that Enables Wearable Visual Monitoring of Physiological Data and Environmental Exposure

一种新型喷涂传感平台技术，可实现生理数据和环境暴露的可穿戴视觉监测

• 批准号: 10578579
• 负责人: Justyn Jaworski
• 金额: $ 26.18万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10578579
• 关键词: Acetone; Acute; Address; Adherence; Amines; Binding; Biological Assay; Biomedical Technology; Breath Tests; Ceramics; Chemical Exposure; Chemicals; Chemistry; Clothing; Color; Corrosion; Custom; Data; Dermal; Detection; Development; Devices; Dose; Electronics; Environmental Exposure; Environmental Health; Environmental Risk Factor; Equity; Ethanol; Evaluation; Exposure to; Formulation; Foundations; Gene Expression Profiling; Health; Healthcare; Home; Hydrogen Bonding; Hydrophobic Interactions; Hypersensitivity skin testing; Immune response; In Vitro; Individual; Intention; Ketoses; Ketosis; Lateral; Lead Poisoning; Measures; Mechanics; Metals; Modality; Modeling; Monitor; Motivation; Pathway interactions; Performance; Persons; Physiologic Monitoring; Physiological; Polymers; Population; Privacy; Property; Radiometry; Research; Resistance; Risk; Risk Assessment; Rotation; Safety; Self Perception; Skin; Solvents; Specific qualifier value; Specificity; Stimulus; Surface; Sweat test; System; Technology; Testing; Textiles; Time; Toxicant exposure; UV Radiation Exposure; Ultraviolet Rays; Vertebral column; Visual; Water; Work; adverse outcome; amphiphilicity; biomaterial compatibility; carboxylate; carboxylation; clinical diagnostics; cost; cost effective; design; digital; efficacy evaluation; experience; future implementation; health data; health disparity populations; improved; in vitro testing; innovation; interest; irritation; lead exposure; liquid crystal; literacy; mechanical properties; monomer; novel; point of care; polydiacetylene; polymerization; prevent; resilience; response; sensor; sensor technology; skin irritation; success; surgical mask; technology platform; wearable device; wearable health device; wearable monitor

Abstract Wearable sensing has the potential to transform health care by alerting users about important information regarding their health and potential exposure to environmental risks. Some of the most critical barriers to wearable sensing include the cost, complexity, and reliability. Addressing the first two challenges is particularly important to prevent exacerbation of a digital divide in health between those who have access to technologies and the digital literacy to work them and those that do not. A widely deployable sensing platform technology for improving health and wellness that can equitably reach the population is thus needed. Past successes in point- of-care and at-home sensing, including lateral flow sensors, have demonstrated that simple, robust designs that are customizable to different targets can provide significant value and high reliability without the need for electronic systems. With that motivation, we are developing a spray-on sensor technology to serve as a platform for custom wearable coatings that can be easily interpreted by a color change upon exposure to tailored target stimuli. Our encouraging results recently demonstrated a set of proof-of-concept spray-on sensors formulated with diacetylene-containing amphiphiles that could detect physical stimuli (UV radiation) and different chemical targets depending on the amphiphile head-group chemistry. In the proposed project, we are initiating an iterative development approach to understand and enhance the safety and efficacy of our spray-on sensing formulations. In Aim 1, we will focus our efforts on assessing and improving the mechanical properties of our spray-on coating formulations for improved resistance to abrasion and washing without impacting their target sensitivity. Success of this aim will result in a robust coating that can provided reliable sensing throughout conditions experience in routine daily use. In order to provide an understanding of the biocompatibility of distinct formulations that are to be applied directly to the skin for sweat analysis, in Aim 2 we will conduct multiple complementary tests for skin irritation, permeation, and induction of adverse outcome pathways of skin sensitization. Through this aim we will be able to effectively make risk assessments in order to define appropriate exposure limits and if necessary utilize alternative formulation strategies for any components of concern. In Aim 3 with the dual intention of demonstrating the efficacy and reliability of our spray-on approach for different sensing applications, we will examine distinct spray-on formulations with tailored functional head-group chemistry of the diacetylene- amphiphiles for implementation of sweat analysis for lead poisoning, breath analysis for acetone (ketosis), and UV exposure for radiation dosimetry. These three sensor formulations will operate by applying the distinct spray coating onto the skin, onto a surgical mask, or onto fabric (clothing), respectively. By tuning the sensitivity, dynamic range, and selectivity of the individual spray-on sensor formulations for their specified target of interest, these studies will establish this as a novel platform technology for generating spray-on wearable coatings that are capable of reliably monitoring information important to understanding health and environmental exposure.

抽象的 可穿戴传感有潜力通过提醒用户重要信息来改变医疗保健 关于他们的健康和潜在的环境风险暴露。一些最关键的障碍 可穿戴传感包括成本、复杂性和可靠性。解决前两个挑战尤其重要 对于防止能够获得技术的人之间健康方面的数字鸿沟加剧非常重要 以及为他们工作和不为他们工作的人的数字素养。一种可广泛部署的传感平台技术 因此，需要改善全民的健康和福祉。过去的成功点- 护理和家庭传感，包括侧流传感器，已经证明简单、稳健的设计 可针对不同目标进行定制，可以提供显着的价值和高可靠性，而无需 电子系统。出于这种动机，我们正在开发一种喷涂传感器技术作为平台 用于定制耐磨涂层，可以通过暴露于定制目标后的颜色变化轻松解释 刺激。我们最近取得的令人鼓舞的结果展示了一套经过概念验证的喷涂传感器 含有丁二炔的两亲物可以检测物理刺激（紫外线辐射）和不同的化学物质 目标取决于两亲物头基化学。在拟议的项目中，我们正在启动迭代 开发方法来了解和提高我们的喷雾传感配方的安全性和功效。 在目标 1 中，我们将集中精力评估和改进喷涂涂层的机械性能 配方可提高耐磨性和耐洗涤性，而不影响其目标灵敏度。成功 这一目标的实现将产生坚固的涂层，可以在各种条件下提供可靠的传感 常规日常使用。为了提供对不同制剂的生物相容性的理解， 直接应用于皮肤进行汗液分析，在目标2中我们将对皮肤进行多项补充测试 刺激、渗透和诱导皮肤致敏的不良结果途径。通过这个目标我们将 能够有效地进行风险评估，以确定适当的暴露限值，并在必要时 对任何关注的成分采用替代配方策略。在目标 3 中，具有双重意图 展示我们的喷涂方法对于不同传感应用的有效性和可靠性，我们将 使用丁二炔的定制功能头基化学检查不同的喷雾配方 两亲物用于铅中毒的汗液分析、丙酮（酮症）的呼气分析，以及 用于辐射剂量测定的紫外线照射。这三种传感器配方将通过应用不同的喷雾来操作 分别涂在皮肤上、外科口罩上或织物（衣服）上。通过调整灵敏度， 动态范围以及各个喷涂传感器配方对其指定感兴趣目标的选择性， 这些研究将使其成为一种新颖的平台技术，用于生成喷涂耐磨涂层， 能够可靠地监测对于了解健康和环境暴露很重要的信息。