Effects of a higher protein diet and resistance training on fat free mass retention during weight loss in adults over 50: A Pilot Sequential Multiple Assignment Randomized Trial

高蛋白饮食和阻力训练对 50 岁以上成年人减肥期间无脂肪质量保留的影响：一项试点序贯多重分配随机试验

• 批准号: 10570914
• 负责人: Richard Drew Sayer
• 金额: $ 12.94万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-10 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10570914
• 关键词: Activities of Daily Living; Address; Adherence; Adult; Aerobic; Aging; Alabama; Automobile Driving; Award; Balance training; Behavior; Behavior Therapy; Body Composition; Body Weight decreased; Body fat; Classification; Clinical; Clinical Trials; Consumption; Counseling; Data; Development; Diet; Dietary Intervention; Dietary Proteins; Education; Effectiveness of Interventions; Energy consumption; Enrollment; Ensure; Equilibrium; Exercise; Fatty acid glycerol esters; Funding; Goals; Grant; Health; Intervention; Intervention Trial; Knowledge; Maintenance; Mentored Research Scientist Development Award; Mentors; Metabolic; Metabolic Diseases; Monitor; Obesity; Outcomes Research; Participant; Phase; Pilot Projects; Proteins; Race; Randomized; Research; Research Project Grants; Resistance; Resources; Role; Scientist; Sequential Multiple Assignment Randomized Trial; Sex Differences; Supervision; Supplementation; Testing; Training; United States National Institutes of Health; Universities; Weight; Whey Protein; Woman; Work; Yoga; aged; biological sex; career; career development; community setting; design; dietary restriction; disorder risk; effectiveness research; exercise intervention; exercise prescription; exercise training; feasibility trial; flexibility; functional loss; improved; individual response; intervention effect; men; muscle form; nutrition; preference; preservation; prevent; programs; recruit; rehabilitation research; resistance exercise; response; sarcopenia; sarcopenic obesity; secondary analysis; skeletal muscle wasting; skills; treatment strategy; trial design; weight loss intervention; weight loss program

PROJECT SUMMARY/ABSTRACT Dr. Sayer’s career goal is to become an independent translational obesity scientist at the University of Alabama at Birmingham (UAB) with a research program focused on the development of pragmatic and adaptive weight loss interventions that can be rapidly implemented in clinical and community settings. The proposed K01 training plan and research project will provide the knowledge, skills, and abilities to launch his independent research career in pursuit of his long-term goals. Dr. Sayer’s training plan includes a combination of formal didactic training available through the UAB Center for Outcomes and Effectiveness Research and Education (directed by Dr. Kenneth Saag, Co-Mentor) as well as rigorous hands-on and personalized training through the NIH National Rehabilitation Research Resource to Enhance Clinical Trials (directed by Dr. Marcas Bamman, Co-Mentor), UAB Nutrition Obesity Research Center (directed by Dr. James Hill, Primary Mentor), and UAB Comprehensive Center for Health Aging (directed by Dr. Cynthia Brow, Co-Mentor). The proposed K01 research is a pilot Sequential Multiple Assignment Randomized Trial (SMART) using a high protein diet and resistance training to promote the retention of fat free mass during weight loss in men with obesity aged 50 and older. The primary objectives of the research are to provide critical preliminary data on 1) the feasibility of conducting a full-scale SMART, 2) estimates of intervention effects and their variances, and 3) moderators or predictors of intervention responsiveness that may serve as tailoring variables for a full-scale SMART. Dr. Sayer will leverage data and training resulting from the proposed K01 to successfully compete for R01-level research funding to develop and rigorously evaluate a full-scale SMART designed to construct an optimal adaptive treatment strategy using a HP diet and RT for preventing and/or treating sarcopenic obesity.

项目概要/摘要 Sayer 博士的职业目标是成为阿拉巴马大学的独立转化肥胖科学家 伯明翰 (UAB) 的一个研究项目专注于实用和适应性体重的开发 可以在临床和社区环境中快速实施的损失干预措施 拟议的 K01 培训。 计划和研究项目将提供开展独立研究的知识、技能和能力 Sayer 博士的培训计划包括正式的教学培训相结合。 可通过 UAB 成果和有效性研究与教育中心（由 Dr. Kenneth Saag，联合导师）以及通过 NIH National 进行的严格实践和个性化培训 加强临床试验的康复研究资源（由共同导师 Marcas Bamman 博士指导），UAB 营养肥胖研究中心（由主要导师 James Hill 博士指导）和 UAB 综合中心 健康老龄化中心（由共同导师 Cynthia Brow 博士指导）拟议的 K01 研究是一项试点。 使用高蛋白饮食和阻力训练的序贯多重分配随机试验（SMART） 促进 50 岁及以上肥胖男性减肥期间保持无脂肪质量。 该研究的目的是提供以下方面的关键初步数据：1）进行全面研究的可行性 SMART，2）干预效果及其方差的估计，以及 3）干预的调节因素或预测因素 Sayer 博士将利用数据和响应能力作为全面 SMART 的定制变量。 拟议的 K01 所产生的培训，以成功竞争 R01 级研究经费，以开发和 严格评估全面的 SMART，旨在使用 HP 构建最佳自适应治疗策略 用于预防和/或治疗肌肉减少性肥胖的饮食和 RT。