Molecular Mechanisms of Disease

疾病的分子机制

• 批准号: 8855964
• 负责人: Paul N. Black
• 金额: $ 11.85万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8855964
• 关键词: Disease; Molecular

 DESCRIPTION (provided by applicant): The University of Nebraska-Lincoln proposes to establish the Molecular Mechanisms of Disease (MMoD) predoctoral training program to provide innovative training and career development in biomedical research centered on molecular interactions and chemical transformations. The program bridges a nine-state gap in the NIH training focus of Cellular, Biochemical, and Molecular Sciences. The goal of the program is to develop outstanding new scientists who work in collaborative multi-disciplinary teams to research disease mechanisms using quantitative approaches that ultimately yield tangible strategies for prevention and therapy. To accomplish this goal, the program will recruit high-quality, motivated predoctoral trainees with a strong interest in the underlying causes of human disease and engage them in mentored, cutting-edge research. The specific aims are to: (1) Provide a rigorous curriculum and innovative, collaborative research opportunities for sixteen predoctoral trainees per year (eight NIH-supported and eight institutionally supported) to become experts in the mechanistic study of human disease; (2) Cultivate an interactive training environment that emphasizes development of outstanding skills in professional networking, grantsmanship, leadership, and written and oral communication; (3) Support collaborative training efforts of mentors in four areas of mechanistic disease research emphasis: molecular signaling, metabolic integrity, oxidative stress, and disease microenvironment. NIH support will span two years of a five-year program for trainees with undergraduate laboratory experience and one year of graduate-level coursework prior to the T32 training period. Selection of new trainees will be competitive, based on strong academic record, research progress and potential, and an original collaborative proposal bridging disciplinary boundaries for innovative thesis research. The MMoD mentoring team spans seven departments and three colleges and includes 28 faculty members, all with strong histories in biomedical research funding and graduate student mentoring. Trainees will complete four research rotations in year 1 before choosing a faculty mentor representing one of the four emphasis areas. Trainees will take a flexible core curriculum: Metabolic Function and Dysfunction, one Quantitative Biology course from an approved core, and two Macromolecules courses from an approved core. Through these courses, they will receive formal training in grantsmanship, scientific writing, and research and journal article presentations. They will also be provided with unique entrepreneurial learning and teaching opportunities and will organize an annual symposium centered on the meeting of the program's external advisory committee. The MMoD program will provide a framework that enables trainees to assemble a broad knowledge base; actively seek research collaborations; produce an outstanding record of original published research; and develop presentation, proposal-writing, and leadership skills that will position them for future excellence as independent researchers focused on mechanisms of disease progression.

 描述（由应用提供）：内布拉斯加州林肯大学的提议，建立疾病分子机制（MMOD）培训前培训计划，以提供以分子相互作用和化学转化为中心的生物医学研究中的创新培训和职业发展。该计划在细胞，生化和分子科学的NIH训练重点中桥接了九个州的差距。该计划的目的是开发杰出的新科学家，他们在合作的多学科团队中工作，使用定量方法研究疾病机制，最终产生切实的预防和治疗策略。为了实现这一目标，该计划将招募对人类疾病的根本原因浓厚兴趣的高质量，有动机的学员，并参与受过指导的尖端研究。具体的目的是：（1）为每年16名占主导地位的学员（八名NIH支持和八名机构支持）提供严格的课程和创新的协作研究机会，以成为人类疾病机械研究的专家； （2）培养一个互动培训环境，该环境强调了专业网络，授予技巧，领导力和书面和口头交流方面的杰出技能的发展； （3）支持在机械疾病研究的四个领域的导师的协作培训工作重点：分子信号传导，代谢完整性，氧化应激和疾病微环境。 NIH的支持将跨越本科实验室经验的学员进行的为期五年的课程，并在T32培训期之前进行一年的研究生课程。基于强大的学术记录，研究进度和潜力，新学员的选择将具有竞争力，以及一个原始的合作提案，弥合创新论文研究的学科界限。 MMOD心理团队跨越了七个系和三所大学，其中包括28位教职员工，所有教师都在生物医学研究资助和研究生心理方面拥有悠久的历史。学员将在第1年完成四次研究轮换，然后选择代表四个强调领域之一的教师心理。学员将参加灵活的核心课程：代谢功能和功能障碍，一项来自认可的核心的定量生物学课程，以及来自认可的核心的两个大分子课程。通过这些课程，他们将获得授予技巧，科学写作和研究的正式培训 和期刊文章演示。他们还将为他们提供独特的企业家学习和教学机会，并将组织以该计划的外部咨询委员会会议为中心的年度研讨会。 MMOD计划将提供一个框架，使学员能够组装一个广泛的知识基础；积极寻求研究合作；产生原始发表研究的杰出记录；以及发展介绍，提案编写和领导能力，将它们定位为未来的卓越，因为独立研究人员专注于疾病进展的机制。