TBI & Alcohol Abuse: Co-occurring Conditions that Enhance Brain Damage

脑外伤性脑损伤

• 批准号: 8838135
• 负责人: Donald M Kuhn
• 金额: --
• 依托单位: JOHN D DINGELL VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8838135
• 关键词: Accident and Emergency department; Accounting; Acute; Afghanistan; Alcohol abuse; Alcohol consumption; Alcoholic Intoxication; Alcohols; Amnesia; Behavioral; Brain; Brain Injuries; Cause of Death; Chronic; Clinical; Closed head injuries; Coin; Conflict (Psychology); Conscious; Detection; Edema; General Population; Glasgow Coma Scale; Goals; Head; Health; Healthcare; Imaging technology; Inflammation; Injury; Iraq; Light; Longevity; Marines; Measures; Methods; Military Personnel; Molecular; Mus; Nature; Nerve Degeneration; Neuraxis; Neurons; Outcome; Outcome Measure; Parkinson Disease; Post-Traumatic Stress Disorders; Prevalence; Public Health; Recovery; Rehabilitation therapy; Reporting; Research; Risk; Self Administration; Severities; Signs and Symptoms; Societies; Soldier; Substance abuse problem; Symptoms; Testing; Time; Trauma; Traumatic Brain Injury; Unconscious State; Veterans; abstracting; alcohol abuse therapy; alcohol exposure; base; body system; cognitive ability; cognitive function; combat; cost; design; disability; high risk; hypoperfusion; mental state; mild traumatic brain injury; mouse model

DESCRIPTION (provided by applicant): Project summary/abstract Traumatic brain injury (TBI) results from a blow to the head and can range in severity from mild (e.g., brief change in mental status or consciousness) to severe (e.g., extended unconsciousness, prolonged amnesia, altered cognitive function). Trauma to the brain is the most likely type of injury to cause death or permanent disability. The costs of TBI to our society are enormous when measured by any criterion. In the general population, the risk of TBI is fairly constant throughout the lifespan, but military personnel are at much higher risk. In fact, TBI has been coined the "signature" injury suffered by soldiers and marines serving in Afghanistan and Iraq and accounts for about 30% of all combat casualties. It has been estimated that 10-20% of veterans of the current conflicts (150,000-300,000) have TBI of some kind. TBI is most accurately classified as a polytrauma in light of the fact that multiple organ systems can be altered. What is more, the effects of even mild TBI are cumulative and can increase the risk of co-morbid illnesses involving the central nervous system such as PTSD and Parkinson's disease. Substance abuse and alcohol abuse in particular, is a major complicating factor in TBI and should also be considered as a co-occurring condition in its own right. Alcohol abuse is steadily increasing among active military personnel and has long been a serious affliction among veterans. Like TBI, alcohol abuse can cause damage to the CNS but very little is known about how alcohol influences the severity and outcome of TBI. Recognizing that alcohol abuse and TBI are bi-directionally related for risk and consequences, the goal of research in this application is to achieve a better understanding of how these two conditions interact to determine long-term outcomes. To achieve this goal, Specific Aim 1 will analyze how binge alcohol intake prior to TBI alters the major signs and symptoms of brain injury to include edema, hypoperfusion, increased inflammation, neuronal damage, and diminished cognitive ability. Specific Aim 2 will evaluate these same outcome measures when binge alcohol treatment follows TBI. Specific Aim 3 will determine if TBI subsequently increases voluntary intake of alcohol. We will use validated mouse models of closed head injury and binge alcohol intoxication to pursue the goals of this application.

描述（由申请人提供）： 项目摘要/抽象创伤性脑损伤（TBI）是由于对头部的打击而导致的，并且严重程度从轻度（例如，精神状态或意识的短暂变化）到严重（例如，延长的无意识，长时间的失忆，认知功能改变）。大脑的创伤是导致死亡或永久残疾的最可能的伤害类型。 TBI的费用 通过任何标准衡量，我们的社会都是巨大的。在普通人群中，TBI的风险在整个生命周期中相当稳定，但军事人员的风险要高得多。实际上，TBI已被造成了在阿富汗和伊拉克服役的士兵和海军陆战队造成的“签名”伤害，占所有战斗人员伤亡的30％。据估计，目前冲突中有10-20％的退伍军人（150,000-300,000）具有某种TBI。鉴于可以改变多个器官系统的事实，TBI最精确地归类为多发性。更重要的是，即使是轻度TBI的影响也是累积性的，并且会增加涉及中枢神经系统（例如PTSD和Parkinson病）的合并症疾病的风险。尤其是药物滥用和酗酒是TBI的主要复杂因素，也应被视为一种本身的同时发生状况。在活跃的军事人员中，酗酒正在稳步增加，并且长期以来一直是退伍军人的严重痛苦。像TBI一样，酒精滥用会对中枢神经系统造成损害，但对于酒精如何影响TBI的严重性和结果知之甚少。认识到酒精滥用和TBI在风险和后果上是双向相关的，因此在本应用中进行研究的目的是更好地了解这两种情况如何相互作用以确定长期结果。为了实现这一目标，具体的目标1将分析在TBI之前如何暴饮暴食的摄入量如何改变脑损伤的主要体征和症状，包括水肿，炎症，炎症增加，神经元损害，神经元损害和认知能力降低。当狂饮酒精治疗跟随TBI时，具体目标2将评估这些相同的结果指标。特定的目标3将确定TBI随后是否会增加对酒精的自愿摄入量。我们将使用经过验证的闭合头部损伤和暴饮暴食的鼠标模型来追求该应用程序的目标。