TBI & Alcohol Abuse: Co-occurring Conditions that Enhance Brain Damage

脑外伤性脑损伤

• 批准号: 8838135
• 负责人: Donald M Kuhn
• 金额: --
• 依托单位: JOHN D DINGELL VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8838135
• 关键词: Accident and Emergency department; Accounting; Acute; Afghanistan; Alcohol abuse; Alcohol consumption; Alcoholic Intoxication; Alcohols; Amnesia; Behavioral; Brain; Brain Injuries; Cause of Death; Chronic; Clinical; Closed head injuries; Coin; Conflict (Psychology); Conscious; Detection; Edema; General Population; Glasgow Coma Scale; Goals; Head; Health; Healthcare; Imaging technology; Inflammation; Injury; Iraq; Light; Longevity; Marines; Measures; Methods; Military Personnel; Molecular; Mus; Nature; Nerve Degeneration; Neuraxis; Neurons; Outcome; Outcome Measure; Parkinson Disease; Post-Traumatic Stress Disorders; Prevalence; Public Health; Recovery; Rehabilitation therapy; Reporting; Research; Risk; Self Administration; Severities; Signs and Symptoms; Societies; Soldier; Substance abuse problem; Symptoms; Testing; Time; Trauma; Traumatic Brain Injury; Unconscious State; Veterans; abstracting; alcohol abuse therapy; alcohol exposure; base; body system; cognitive ability; cognitive function; combat; cost; design; disability; high risk; hypoperfusion; mental state; mild traumatic brain injury; mouse model

DESCRIPTION (provided by applicant): Project summary/abstract Traumatic brain injury (TBI) results from a blow to the head and can range in severity from mild (e.g., brief change in mental status or consciousness) to severe (e.g., extended unconsciousness, prolonged amnesia, altered cognitive function). Trauma to the brain is the most likely type of injury to cause death or permanent disability. The costs of TBI to our society are enormous when measured by any criterion. In the general population, the risk of TBI is fairly constant throughout the lifespan, but military personnel are at much higher risk. In fact, TBI has been coined the "signature" injury suffered by soldiers and marines serving in Afghanistan and Iraq and accounts for about 30% of all combat casualties. It has been estimated that 10-20% of veterans of the current conflicts (150,000-300,000) have TBI of some kind. TBI is most accurately classified as a polytrauma in light of the fact that multiple organ systems can be altered. What is more, the effects of even mild TBI are cumulative and can increase the risk of co-morbid illnesses involving the central nervous system such as PTSD and Parkinson's disease. Substance abuse and alcohol abuse in particular, is a major complicating factor in TBI and should also be considered as a co-occurring condition in its own right. Alcohol abuse is steadily increasing among active military personnel and has long been a serious affliction among veterans. Like TBI, alcohol abuse can cause damage to the CNS but very little is known about how alcohol influences the severity and outcome of TBI. Recognizing that alcohol abuse and TBI are bi-directionally related for risk and consequences, the goal of research in this application is to achieve a better understanding of how these two conditions interact to determine long-term outcomes. To achieve this goal, Specific Aim 1 will analyze how binge alcohol intake prior to TBI alters the major signs and symptoms of brain injury to include edema, hypoperfusion, increased inflammation, neuronal damage, and diminished cognitive ability. Specific Aim 2 will evaluate these same outcome measures when binge alcohol treatment follows TBI. Specific Aim 3 will determine if TBI subsequently increases voluntary intake of alcohol. We will use validated mouse models of closed head injury and binge alcohol intoxication to pursue the goals of this application.

描述（由申请人提供）： 项目摘要/摘要 创伤性脑损伤 (TBI) 是由头部受到打击造成的，严重程度从轻度（例如，精神状态或意识的短暂变化）到重度（例如，长时间失去知觉、长时间失忆、认知功能改变）不等。 。脑外伤是最有可能导致死亡或永久残疾的伤害类型。 TBI 的费用 无论以任何标准来衡量，我们的社会都是巨大的。在一般人群中，TBI 的风险在整个生命周期中相当稳定，但军事人员的风险要高得多。事实上，TBI 被认为是在阿富汗和伊拉克服役的士兵和海军陆战队遭受的“标志性”伤害，约占所有战斗伤亡的 30%。据估计，参与当前冲突的退伍军人（150,000-300,000 人）中有 10-20% 患有某种类型的创伤性脑损伤。鉴于多个器官系统可能发生改变，TBI 最准确地被归类为多发伤。更重要的是，即使是轻微的创伤性脑损伤的影响也会累积，并可能增加涉及中枢神经系统的共病的风险，例如创伤后应激障碍和帕金森病。药物滥用和酒精滥用是导致 TBI 的一个主要复杂因素，也应将其本身视为一种并发疾病。现役军人的酗酒现象正在稳步增加，长期以来一直是退伍军人的严重困扰。与 TBI 一样，酗酒也会对中枢神经系统造成损害，但人们对酒精如何影响 TBI 的严重程度和结果知之甚少。认识到酗酒和 TBI 的风险和后果是双向相关的，本申请的研究目标是更好地了解这两种情况如何相互作用以确定长期结果。为了实现这一目标，具体目标 1 将分析 TBI 之前的暴饮暴食如何改变脑损伤的主要体征和症状，包括水肿、灌注不足、炎症增加、神经元损伤和认知能力下降。具体目标 2 将评估 TBI 后酗酒治疗时的这些相同结果指标。具体目标 3 将确定 TBI 随后是否会增加自愿饮酒量。我们将使用经过验证的闭合性头部损伤和酗酒中毒的小鼠模型来实现该应用的目标。