Driving Biomedical Projects

推动生物医学项目

• 批准号: 10089606
• 负责人: william milo westler
• 金额: $ 19.97万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-02 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10089606
• 关键词: Antifungal Agents; Area; Arizona; Automobile Driving; Back; Beds; Biodiversity; Biological; Blood coagulation; Characteristics; Chemicals; Collaborations; Complex; Data; Data Collection; Detection; Development; Disease; Electronic Mail; Ensure; Environment; Enzymes; Evaluation; Future; Homo; Horns; Illinois; Ion Channel; Isotopes; Joints; Label; Length; Lewy Bodies; Measurement; Membrane; Membrane Potentials; Membrane Proteins; Michigan; Motivation; Multienzyme Complexes; Nucleic Acids; Pharmaceutical Preparations; Preparation; Procedures; Process; Progress Reports; Property; Proteins; Proton-Motive Force; Protons; RNA; Reproducibility; Resolution; Rotation; Sampling; Selection Criteria; Services; Signaling Protein; Site Visit; Sterols; Structure; System; TRP channel; Technology; Telephone; Tertiary Protein Structure; Testing; Texas; Therapeutic; Time; Tissues; Universities; Validation; Videoconferencing; Washington; biological systems; chemical synthesis; experimental study; improved; innovation; instrument; meetings; new technology; pre-clinical; protein complex; recruit; sensor; small molecule; solid state nuclear magnetic resonance; technology development; technology research and development; tool; translational impact; voltage; voltage gated channel

DRIVING BIOMEDICAL PROJECTS SUMMARY Development of new technology is driven by the desire to perform experiments for which the tools do not yet exist. Our driving biomedical projects are selected because they each have biologically significant open questions that motivate our specific technology development projects. They have unique features that either facilitate intermediate steps in technology development or make them particularly well-suited to demonstrate the power and impact of our new technology. They are chosen to represent a broad cross-section of biological systems, including channels, transporters, signaling proteins, enzymes, protein/nucleic acid complexes, and intrinsically disordered proteins. Application of our new technology to these projects also has the potential to impact our understanding of a number of different biomedical conditions and diseases. Together, this set of DBPs provides an initial test bed for our technology and opportunity to demonstrate the broad scope of potential applications for our technology.

推动生物医学项目摘要 新技术的开发是由进行工具尚未完成的实验的愿望所驱动的 存在。选择我们推动的生物医学项目是因为它们每个都具有生物学上重要的开放性 激发我们特定技术开发项目的问题。它们具有独特的功能 促进技术开发的中间步骤或使它们特别适合展示 我们新技术的力量和影响。他们被选择代表生物的广泛横截面 系统，包括通道、转运蛋白、信号蛋白、酶、蛋白质/核酸复合物，以及 本质上无序的蛋白质。我们的新技术在这些项目中的应用还有可能 影响我们对许多不同生物医学状况和疾病的理解。综合起来，这一套 DBP 为我们的技术提供了一个初始测试平台，并提供了展示广泛范围的机会 我们的技术的潜在应用。