COG NCTN Network Group Operations Center

COG NCTN网络集团运营中心

基本信息

批准号：
9132522
负责人：
PETER C. ADAMSON
金额：
$ 7.37万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-11 至 2019-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9132522
关键词：
Acute Adolescent Adolescent and Young Adult Adult Age Australia Biology Cancer Center Cancer Patient Cancer Survivor Caring Child Childhood Childhood Leukemia Clinical Clinical Medicine Clinical Research Clinical Trials Design Collaborations Collection Communities Development Diagnosis Disease Dose Enrollment Ensure Europe Family Foundations Generations Goals Health Institution Interdisciplinary Study Knowledge Laboratories Lead Malignant Childhood Neoplasm Malignant Neoplasms Methods Mission Molecular Morbidity - disease rate National Clinical Trials Network New Zealand North America Outcome Patients Pediatric Hospitals Pediatric Oncology Group Process Productivity Publishing Quality of life Rare Diseases Research Research Infrastructure Scientist Site Strategic Planning Structure Survival Rate Survivors Translational Research Universities Work anticancer research base cancer therapy chemotherapy design improved innovation member novel therapeutic intervention operation organizational structure outcome forecast population based programs small molecule success survivorship translational study

项目摘要

DESCRIPTION (provided by applicant): Since the introduction of chemotherapy for the treatment of childhood leukemia more than sixty years ago, the, prognosis for children with cancer has improved dramatically. The 5-year survival rate for childhood cancers, many of which were uniformly fatal in the pre-chemotherapy era, is now approaching.80%. Despite these advances, several childhood cancers still have unacceptably low cure rates, and even when treatment is successful, the acute and long-term morbidity of current therapy can be substantial. The Children's Oncology Group (COG), the world's largest organization devoted exclusively to childhood and adolescent cancer research, was founded 12 years ago. The COG's multidisciplinary research team, comprised of more than 8,000 members, conducts research at more than 200 leading children's hospitals, universities, and cancer centers. This proposal is for COG, as part of NCI's new National Clinical Trials Network, to continue its collaborative research work that supports the mission of improving the outcome for all children with cancer. The COG will design and conduct clinical-translational studies for children with cancer that builds on an increasing understanding of the molecular basis for pediatric malignancies and has the highest potential to improve the outcome. Using innovative clinical trial designs suitable for the study of rare diseases, we will study novel therapeutic approaches that range from targeted, small molecules to cellular therapies. As more than 90% of children diagnosed with cancer in the US are treated at COG member institutions, the COG has the ability to offer to children with cancer and their families to participation in research that allows for collection and annotation of biospecimens from all children with cancer, providing the foundation for discovery and accelerating the most promising research efforts conducted in laboratories around the world. The COG research portfolio importantly also includes research trials focused on improving the quality of life children with cancer and survivors. The proposal is for support of the COG Group Operations Center, clinician-scientists who develop and conduct research, and for member sites to participate through enrollment of eligible subjects.

描述（由申请人提供）：自六十多年前引入了用于治疗儿童白血病的化学疗法以来，对癌症儿童的预后却显着改善。儿童期癌症的5年生存率（其中许多在化学疗法时代都统一致命，现在已经接近80％。尽管有这些进展，但几种童年癌的治疗率仍然令人难以置信，即使治疗成功，当前疗法的急性和长期发病率也可能很大。 12年前成立了全球最大的组织儿童肿瘤学小组（COG）。 COG的多学科研究团队由8,000多名成员组成，在200多个领先的儿童医院，大学和癌症中心进行了研究。作为NCI新的国家临床试验网络的一部分，该建议是针对COG的，旨在继续其协作研究工作，该工作支持改善所有癌症儿童的结果。 COG将针对癌症儿童设计和进行临床翻译研究，这基于对小儿恶性肿瘤分子基础的越来越多的理解，并且具有改善结果的最高潜力。使用适用于稀有疾病研究的创新临床试验设计，我们将研究从靶向小分子到细胞疗法的新型治疗方法。由于在COG成员机构接受了90％以上的诊断为癌症的儿童，因此COG有能力向患有癌症的儿童及其家人提供研究，从而可以收集和注释所有癌症儿童的生物测量为发现和加速在世界各地实验室进行的最有前途的研究工作提供了基础。 COG研究组合还重要的是，研究试验的重点是改善儿童和幸存者的生活质量。该提案是为了支持COG集团运营中心，开发和进行研究的临床医生，以及成员站点通过符合条件的受试者的参与。