Racial Disparity of microRNA in Hepatitis C Virus Mediated Hepatocellularcarcinoma

丙型肝炎病毒介导的肝细胞癌中 microRNA 的种族差异

• 批准号: 8872288
• 负责人: Ratna B. Ray
• 金额: $ 21.25万
• 依托单位: SAINT LOUIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8872288
• 关键词: Address; African American; Area; Biological Markers; Biopsy Specimen; Caucasians; Chronic Hepatitis C; Data; Death Rate; Development; Disease Progression; Ethnic group; Genetic; Goals; Growth; Hepatitis C; Hepatitis C Incidence; Hepatitis C virus; Hepatocyte; Human; Laboratory Finding; Liver diseases; Malignant neoplasm of liver; Mediating; Medical; MicroRNAs; Modality; Molecular; Patients; Play; Primary carcinoma of the liver cells; Process; Race; Regulation; Research; Research Proposals; Risk Factors; Role; Serum; Staging; Therapeutic; Up-Regulation; Virus; caucasian American; cell growth; circulating microRNA; cohort; innovation; interest; liver biopsy; loss of function; public health relevance; racial disparity

 DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) mediated end stage liver disease, including hepatocellular carcinoma (HCC), is a growing problem among African Americans (AAs). The central goal of this project is to investigate the racial disparity of HCV mediated liver cancer. HCV infection mediated death rate among AA patients is about 2- fold higher than CA. Very little information is available about the underlying mechanisms of liver disease progression among chronically HCV infected ethnic groups. Our research proposal will examine this previously unexplored area of HCV mediated end stage liver disease among AA. microRNAs (miRNAs) play critical roles in multi-step cell growth regulatory processes, and the relationship between chronic HCV infection and miRNA expression is of considerable interest in understanding virus mediated disease progression. Our preliminary data indicated a group of microRNAs modulated in chronically HCV infected AA sera as compared to that of CA. We hypothesize that these circulatory miRNAs can be potential predictive biomarker towards HCC development in HCV infected AA patients, and are involved deregulating hepatocyte growth. Thus, identification of predictive biomarkers for HCC and the underlying molecular mechanisms for race disparity will have a great translational benefit. Our long term objectives are to translae these findings from the laboratory to the bedside identifying predictive biomarker, and developing therapeutic modalities for HCV mediated liver disease progression. Impact: The results from this R21 exploratory proposal will have a high impact by investigating the role of miRNAs as genetic factors for understating racial disparity. Our research will explain why African Americans have higher incidence of HCV mediated liver cancer as compared to Caucasians.

 描述（由申请人证明）：非洲裔美国人中肝炎病毒（HCV）介导的末期肝病问题（AAS）。族裔群体。 AA患者，识别HCC的预测性生物标志物和种族差异的基本分子将具有很大的转化益处。 MiRNA的作用具有很大的影响。