Epigenetic mechanisms regulating neuron production during cortical development

皮质发育过程中调节神经元产生的表观遗传机制

基本信息

批准号：
10259827
负责人：
Louis-Jan Pilaz
金额：
$ 46.37万
依托单位：
SANFORD RESEARCH/USD
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10259827
关键词：
Advisory Committees Animal Model Applications Grants Basic Science Biochemical Biochemistry Bioinformatics Caring Cell Proliferation Cell physiology Cells Cellular biology Centers of Research Excellence Cessation of life Child Child Development Child Health Childhood Clinic Clinical Clinical Research Communities Complement Core Facility Data Development Developmental Biology Developmental Process Diagnosis Disease Effectiveness Environment Epigenetic Process Evaluation Fostering Foundations Funding Genetic Genetic Diseases Goals Growth and Development function Health Healthcare Systems Human Biology Human Development Image Institution Interdisciplinary Study K-12 student Leadership Learning Medical Students Medicine Mentors Mentorship Mind Modeling Molecular Molecular Biology Morphogenesis Neurons Pediatric Hospitals Pediatric Research Phase Physicians Plant Roots Postdoctoral Fellow Production Regulation Research Research Activity Research Personnel Research Project Grants Research Training Resources Role Rural Science Scientist Sioux Falls South Dakota Technical Expertise Training Translational Research United States United States National Institutes of Health base collaborative environment data submission experience fetal programming functional genomics graduate student human disease improved innovation learning community medical specialties member migration multidisciplinary northern plains outreach pressure recruit skills success supportive environment training opportunity translational study undergraduate student

项目摘要

The primary goal of this application is to establish a foundation of basic scientists with translational research projects studying developmental mechanisms underlying children’s disease by establishing the Center for Pediatric Research. The origin of many pediatric diseases is from altered developmental programming related to the processes of cell proliferation, morphogenesis, migration, differentiation, and programmed death. These developmental processes are at the root of pediatric disease and are disrupted through genetic disorders, aberrant fetal programming, altered growth & development, and environmental pressures. Our multidisciplinary Center applies genetic, biochemical, cell, and molecular approaches across several model organisms to characterize alterations during development as they pertain to pediatric diseases and disorders. For phase II we will continue to build upon the success of phase I efforts to create a critical mass of independently funded investigators within the Center for Pediatric Research by refining our focus to support and mentor junior investigators whose research investigates how key regulators of cellular pliancy contribute to the developmental origin of pediatric disorders. Center success will be achieved through the following Aims: 1) create a supportive environment for the training and mentorship of scientists studying how regulation of cell pliancy contributes to pediatric diseases; 2) utilize and enhance existing resources that will enable pediatric research; 3) expand training and learning opportunities in developmental biology and pediatric disease; and 4) evaluate success of the Center. Through these Aims, the Center for Pediatric Research will develop a strong foundation in basic and translational research by fostering a collaborative environment for scientists and physicians. Strengthened by our institution’s strong commitment to children’s medicine, we propose that the Center will continue to enhance pediatric research efforts in South Dakota.

该应用程序的主要目标是通过转化研究为基础科学家奠定基础通过建立儿童疾病中心来研究儿童疾病的发育机制儿科研究。许多儿科疾病的起源与发育程序的改变有关。细胞增殖、形态发生、迁移、分化和程序性死亡的过程。发育过程是儿科疾病的根源，并因遗传性疾病而受到干扰，胎儿编程异常、生长发育改变以及环境压力。该中心将遗传、生化、细胞和分子方法应用于多种模式生物描述与儿科疾病和失调有关的发育过程中的变化。我们将继续在第一阶段努力的成功基础上再接再厉，创建足够数量的独立资助的项目儿科研究中心的研究人员通过将我们的重点放在支持和指导初级儿童上研究人员的研究调查了细胞柔顺性的关键调节因子如何促进儿科疾病的发育起源中心将通过以下目标实现：1) 为研究细胞调控的科学家创造一个支持性环境柔韧性有助于儿科疾病；2) 利用和增强现有资源，使儿科疾病能够得到改善研究；3) 扩大发育生物学和儿科疾病方面的培训和学习机会；4) 通过这些目标，儿科研究中心将发展出强大的力量。通过为科学家和科学家营造协作环境，奠定基础和转化研究的基础由于我们机构对儿童医学的坚定承诺，我们建议：中心将继续加强南达科他州的儿科研究工作。