K24 Mid-Career Investigator Award in Eating and Weight Disorders

K24 饮食和体重失调领域职业生涯中期研究员奖

基本信息

批准号：
8690832
负责人：
CARLOS M GRILO
金额：
$ 17.18万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8690832
关键词：
Acute Address Aftercare Alcohol or Other Drugs use Area Award Behavior Therapy Behavioral Binge Eating Binge eating disorder Biometry Body Weight decreased Caring Clinical Clinical Research Cognitive Therapy Collaborations Decision Trees Disease Early treatment Eating Eating Disorders Effectiveness Ensure Equilibrium Faculty Foundations Functional Magnetic Resonance Imaging Funding General Practitioners Goals Grant Intervention Investigation K-Series Research Career Programs Maintenance Matched Group Mediator of activation protein Medical Mentors Methods Mid-Career Clinical Scientist Award (K24)Neurobiology Nursing Faculty Obesity Outcome Paper Participant Patients Pharmaceutical Preparations Pharmacotherapy Pilot Projects Placebos Primary Health Care Protocols documentation Public Health Publishing Randomized Relative (related person)Research Research Peer Review Research Personnel Research Project Grants Research Support Research Training Resources Secure Specialized Center Testing Time Training Programs Treatment Efficacy Treatment outcome United States National Institutes of Health Weight arm base career career development cognitive control cost effectiveness design improved next generation patient oriented research primary care setting programs relating to nervous system response reward processing self help sibutramine skills standard care treatment effect treatment response

项目摘要

DESCRIPTION (provided by applicant): This application represents a competitive renewal of a K24 Mid-Career Investigator Award in Patient-Oriented Research in Eating and Weight Disorders. Dr. Grilo is seeking a renewal of the K24 Award in order to relieve him from administrative and clinical duties to ensure protected time to continue to: (1) focus on clinical- research to improve treatment methods for eating/weight disorders; (2) develop advanced research skills needed to enhance further his effectiveness both as a researcher and as a mentor in order to positively impact the next generation of treatment methods and researchers; and (3) mentor postdoctoral clinical researchers and junior faculty in the area of obesity and disordered eating needed to address these growing major public health problems. During the initial funded period, Dr. Grilo completed three RCTs, obtained new funding as PI on two R01s from the NIH and a Foundation Grant to perform RCTs for obese patients with disordered eating in diverse settings, and as co-Investigator on several NIH grants. During the initial K24, Dr. Grilo published 110 peer-reviewed research papers, mentored 20 trainees or junior faculty, mentored six successful NIH Loan Repayment Program applications, and mentored or co-mentored five funded K23 Career Development Awards. A renewal award will allow Dr. Grilo to increase further his integrated research and mentoring activities. Among the on-going studies that will allow for intensive mentoring include a RCT testing a stepped care approach to a standard behavioral weight loss treatment for obese patients with binge eating disorder (R01 DK49587) and a RCT testing cognitive behavioral therapy via self-help and pharmacotherapy, alone and in combination, in obese patients with binge eating disorder in generalist primary care settings (R01 DK073542). A renewal award will allow Dr. Grilo to perform pilot fMRI investigations of neural activation during cognitive control tasks and reward processing in obese patients with binge eating disorder. A renewal award will also allow Dr. Grilo to advance further his scientific capabilities and he has secured the collaboration of internationally-recognized expert consultants in obesity, eating disorders, treatment methods, biostatistics, and neurobiological research. Dr. Grilo's program is integrated with other clinical-research and training programs (e.g., CTSA) at Yale which collectively offer ample opportunities and resources. Dr. Grilo will continue to support and facilitate the advancement of postdoctoral and junior faculty clinical-researchers in eating/weight disorders via intensive mentoring geared towards completing research projects, publishing studies, and successfully obtaining career development (e.g., K23) and research grant support.

描述（由申请人提供）：此申请代表了K24中期研究者饮食和体重疾病研究中的K24中级研究员奖的竞争续约。 Grilo博士正在寻求续签K24奖，以减轻他免于行政和临床职责，以确保受保护的时间继续：（1）专注于临床研究，以改善饮食/体重疾病的治疗方法；（2）发展所需的先进研究技能，以进一步提高他作为研究人员和导师的有效性，以积极影响下一代治疗方法和研究人员；（3）在肥胖和饮食不足的领域，指导博士后临床研究人员和初级教师需要解决这些日益增长的公共卫生问题。在最初的资助期间，Grilo博士完成了三个RCT，在NIH的两个R01上获得了PI的新资金，并获得了基金会赠款，为在各种情况下饮食不当的肥胖患者进行RCT，并在几项NIH赠款中作为共同饮食者进行饮食。在最初的K24期间，Grilo博士发表了110份同行评审的研究论文，指导了20名学员或初级教职员工，指导了6项成功的NIH贷款还款计划申请，并指导或获得了五项资助的K23职业发展奖。续签奖项将使Grilo博士能够进一步增加他的综合研究和指导活动。在正在进行的允许大量指导的正在进行的研究中，包括RCT测试对暴饮暴食障碍（R01 DK49587）的肥胖患者进行标准行为减肥治疗方法，以及通过自助和药物治疗的RCT测试进行认知行为疗法，单独和组合在肥胖的饮食中，在肥胖的患者中，在肥胖的患者中，饮食障碍症3. 3.饮食障碍（均为饮食障碍）。42饮食障碍。续签裁决将使Grilo博士能够对认知控制任务期间的神经激活进行试验性fMRI调查，并在肥胖的暴饮暴食患者中进行奖励处理。续签奖项还将使Grilo博士能够进一步提高他的科学能力，并确保了国际认可的肥胖，饮食失调，治疗方法，生物统计学和神经生物学研究的国际认可的专家顾问的合作。 Grilo博士的计划与耶鲁大学的其他临床研究和培训计划（例如CTSA）集成在一起，该计划共同提供了充足的机会和资源。 Grilo博士将继续支持和促进博士后和初级教师临床研究者在饮食/体重障碍方面的进步，该研究人员致力于完成研究项目，出版研究并成功获得职业发展（例如K23）和研究赠款支持。