Body-machine interfaces after spinal injury: rehabilitation and brain plasticity

脊柱损伤后的身体-机器界面：康复和大脑可塑性

• 批准号: 8838452
• 负责人: Ismael Seanez
• 金额: $ 3.62万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2016-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8838452
• 关键词: Acceleration; Area; Attention; Biological Markers; Brain; Brain region; Calibration; Clinical; Clinical Treatment; Clinical Trials; Computers; Data; Development; Devices; Diffusion; Equilibrium; Goals; Image; Impairment; Individual; Injury; Knowledge; Lead; Learning; Location; Magnetic Resonance Imaging; Magnetism; Maps; Measurement; Measures; Metric; Motion; Motor; Motor Skills; Movement; Muscle; Muscular Atrophy; Nervous system structure; Neurologic; Optics; Paralysed; Participant; Patients; Performance; Physical Efforts; Physical Rehabilitation; Plastics; Population; Process; Recovery; Recovery of Function; Rehabilitation therapy; Resources; Self-Help Devices; Shoulder; Signal Transduction; Spinal Cord; Spinal Injuries; Spinal cord injury; Spinal cord injury patients; Structure; System; Task Performances; Testing; Training; User-Computer Interface; Wheelchairs; Work; base; cerebral atrophy; chronic pain; disability; functional outcomes; gray matter; human subject; improved; kinematics; motor control; motor impairment; motor skill learning; neural patterning; novel; novel strategies; outcome forecast; prevent; public health relevance; relating to nervous system; research clinical testing; research study; sensorimotor system; spinal cord repair; treatment program; two-dimensional; white matter

 DESCRIPTION (provided by applicant): Despite progress in the field of assistive technologies for people who suffered an injury to the spinal cord (SCI), most of the current devices to control computers and wheelchairs are set in place to require as little physical effort as possible from the user, and little attention has been paid to maintaining and strengthening the neural and muscular resources that survived the injury. We recently developed a novel non-invasive body- machine interface (BMI) for the continuous control of a two-dimensional computer cursor using four inertial measurement units (IMUs) placed on the user's upper body. Results on healthy subjects indicate that taking advantage of the redundancy of the signals from the IMUs improved overall performance. In this study we propose to validate our results on people with SCI and determine the rehabilitative effects of practicing upper- body control of personalized interface in this population. A combination of diffusion tension magnetic resonance imaging (DTI), optical tracking, and force and functional clinical evaluations, will provide a framework fo inferring changes in brain structures and motor impairment from task measures provided by an assistive device. Moreover, we will demonstrate the ability of SCI patients to improve-or prevent the degradation of-the motor and neural resources that survived the injury through practice with a BMI.

 描述（由适用提供）：尽管在辅助技术领域为遭受脊髓受伤（SCI）受伤的人的辅助技术取得了进展，但仍设置了当前控制计算机和轮椅的当前设备，以尽可能少地努力从用户那里努力，并且很少关注维持和增强受伤的神经和肌肉资源，以至于生存了受伤。我们最近开发了一种新型的非侵入性身体机器界面（BMI），用于使用放置在用户上半身上的四个惯性测量单元（IMU）连续控制二维计算机光标。健康受试者的结果表明，利用IMU的信号的冗余，改善了整体性能。在这项研究中，我们建议验证我们对SCI患者的结果，并确定在该人群中对个性化界面进行高身控制的康复作用。扩散张力磁共振成像（DTI），光学跟踪以及力和功能性临床评估的结合将提供一个框架，从辅助设备提供的任务指标中推断出大脑结构的变化和运动障碍。此外，我们将证明SCI患者改善或防止通过BMI实践在伤害中幸存下来的运动和神经资源的降解能力。