Next generation partner notification and intervention services

下一代合作伙伴通知和干预服务

基本信息

批准号：
8910524
负责人：
Alida M Bouris
金额：
$ 23.7万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-15 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8910524
关键词：
18 year old AIDS prevention Address Adherence Adoption Anal Sex Area Attention Behavioral Birth Caring Centers for Disease Control and Prevention (U.S.)Characteristics Chicago Client Clinic Clinical Clinical Services Clinical Trials Clinical assessments Contact Tracing Data Development Disease Distal Dose Female Funding Geographic Locations HIV HIV risk Health Imagery Incentives Individual Injection of therapeutic agent Intervention Link Location Low Income Population Manufacturer Name Motivation Participant Partner Notification Persons Pharmaceutical Preparations Play Population Positioning Attribute Prevalence Prevention program Prophylactic treatment Protocols documentation Provider Public Health Randomized Randomized Controlled Trials Recruitment Activity Risk Risk Behaviors Role Safety Sampling Services Sexual Partners Site Specialist Staging Telephone Testing Text Thinking Time Training Underinsured United States Public Health Service Woman clinical care cohort design flexibility high risk improved next generation preference programs safety net service intervention sex treatment as usual

18 year old AIDS prevention Address Adherence Adoption Anal Sex Area Attention Behavioral Birth Caring Centers for Disease Control and Prevention (U.S.)Characteristics Chicago Client Clinic Clinical Clinical Services Clinical Trials Clinical assessments Contact Tracing Data Development Disease Distal Dose Female Funding Geographic Locations HIV HIV risk Health Imagery Incentives Individual Injection of therapeutic agent Intervention Link Location Low Income Population Manufacturer Name Motivation Participant Partner Notification Persons Pharmaceutical Preparations Play Population Positioning Attribute Prevalence Prevention program Prophylactic treatment Protocols documentation Provider Public Health Randomized Randomized Controlled Trials Recruitment Activity Risk Risk Behaviors Role Safety Sampling Services Sexual Partners Site Specialist Staging Telephone Testing Text Thinking Time Training Underinsured United States Public Health Service Woman clinical care cohort design flexibility high risk improved next generation preference programs safety net service intervention sex treatment as usual

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项目摘要

DESCRIPTION (provided by applicant): This developmental application (R34) requests funds to refine and pilot test a flexible Partner notification services Pre-exposure Prophylaxis (PS-PrEP) intervention that will engage existing department of public health (DPH) partner notification services in linkage to clinical PrEP care for at risk HIV seronegative persons from diverse backgrounds. These funds are requested because there remains a stark efficacy implementation divide following randomized controlled trials which have demonstrated partial PrEP efficacy. Following these trials, DPHs have yet to integrate PrEP into existing HIV prevention programs resulting in few people on PrEP and those who might benefit most (highest risk populations) are not receiving it. To address these gaps, we aim to integrate PrEP into existing DPH activities, and in particular, DPH partner notification services. DPH partner notification services implemented by Disease Intervention Specialists (DIS) are widespread in high HIV prevalence areas domestically and have great potential. Partner notification services (engaging the risk partners of newly infected HIV persons), is recommended by the CDC for HIV prevention and is frequently conducted by public health departments. In data from South Chicago over 50% of these risk contacts are HIV infected. This high HIV prevalence outpaces that of traditional risk groups in the same geographic area and suggests that we shift our thinking of who an appropriate candidate for PrEP linkage is from individual risk (anal sex, injecting drugs), to network risk (people connected to HIV infected persons). PS-PrEP tests the integration of PrEP into routine DPH services by training DIS staff to provide brief tailored PrEP linkage planning/motivation, mini-booster sessions via text/phone, and to directly link clients int PrEP care. PS-PrEP will set the stage for a large trial by examining two key components of early PrEP care: 1) efficacy of PS-PrEP in linking high-risk seronegative clients to PrEP care as part of partner notification services; and 2) how personal characteristics (e.g. risk behavior) and downstream PrEP cascade metrics (e.g. retention and adherence to PrEP) of study participants identified through partner notification services compare to other individuals initiating PrEP withi the same clinical context and time frame. We aim to: 1) Refine the PS-PrEP intervention protocol, materials and assessments by shifting more of the intervention to focus on direct PrEP linkage and by developing a network visualization component where participants complete an interactive sociogram of individuals in their own risk network; 2) Pilot test the feasibility (reac, adoption, safety and implementation) and initial efficacy (higher linkage to care) of the PS-PrEP intervention versus treatment as usual at 3 months post randomization among a sample of contacts >18 years old recruited from partner notification services; and 3) Compare sociodemographic, HIV risk and two distal PrEP cascade metrics (retention and adherence) of PS-PrEP intervention participants linked to PrEP care with other individuals initiating PrEP within the same clinical context and time frame (12 months).

描述（由申请人提供）：此发展应用程序（R34）要求资金完善和试点测试灵活的合作伙伴通知服务预防前预防（PS-PREP）干预措施，该干预将与现有的公共卫生部（DPH）合作伙伴通知服务联系，以与来自不同背景的风险艾滋病毒的临床预期联系，以链接到临床预期。之所以要求这些资金，是因为在随机对照试验之后，仍存在明显的功效实施，这些试验表现出部分准备疗效。经过这些试验，DPH尚未将PREP整合到现有的预防艾滋病毒预防计划中，导致很少有PREP的人，而可能受益最多的人（最高风险人群）没有接受。为了解决这些差距，我们旨在将PREP集成到现有的DPH活动中，尤其是DPH合作伙伴通知服务。疾病干预专家（DIS）实施的DPH合作伙伴通知服务在国内较高的艾滋病毒患病率领域普遍存在，并且具有巨大的潜力。伙伴通知服务（与新感染的艾滋病毒患者的风险伴侣与风险合作伙伴有关），由CDC预防艾滋病毒预防，并经常由公共卫生部门进行。在来自南芝加哥的数据中，超过50％的这些风险接触感染了HIV。这种高艾滋病毒的流行率超过了同一地理区域中传统风险群体的流行，这表明我们改变了对谁成为准备联系的适当候选人的想法，是从个人风险（肛交，注射药物）到网络风险（与HIV感染者有关的人）。 PS-PREP测试通过培训DIS员工将PREP集成到常规的DPH服务中，以提供简短的量身定制的PREP链接计划/动机，通过文本/电话提供微型助推器会议，并直接链接客户Int Prep Care。 PS-PREP将通过检查早期预备的两个关键组成部分来为大型试验奠定基础：1）PS-PREP在将高风险血清效力客户端链接到PREP CARE作为合作伙伴通知服务的一部分中的功效； 2）个人特征（例如风险行为）和通过合作伙伴通知服务确定的研究参与者的下游准备级联指标（例如，保留和遵守准备工作）与其他人使用相同的临床环境和时间范围发起PreP的个人相比。我们的目标是：1）通过将更多的干预措施转移到直接准备链接上，并通过开发参与者在自己的风险网络中完成个人的交互式社会图来完善直接准备链接，从而完善PS-PREP干预方案，材料和评估； 2）试点测试PS-PREP干预措施的可行性（RECOC，采用，安全和实施）以及在伴侣通知服务中招募的18岁> 18岁的接触样本中，PS-PREP干预与往常的初始疗效（更高的联系）； 3）比较PS-PREP干预参与者与与其他人相关的PS-PREP干预参与者的社会人口统计学，HIV风险和两个远端准备级联指标（保留和依从性），该参与者与其他人在相同的临床环境和时间范围内发起PREP（12个月）。