Core A - Resource for Clinical Studies of AKI

核心 A - AKI 临床研究资源

• 批准号: 10252037
• 负责人: Ravindra L. Mehta
• 金额: $ 29.94万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10252037
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Adult; Basic Science; Benchmarking; Biological; Biological Assay; Biological Markers; Biometry; Blood; Cardiac Catheterization Procedures; Cardiac Surgery procedures; Caring; Case Report Form; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Sciences; Coupled; DNA; Data; Data Analyses; Data Management Resources; Data Set; Database Management Systems; Databases; Disease; Educational workshop; Epidemiology; Functional disorder; Funding; Goals; Grant; Human; Individual; Injury to Kidney; International; Intervention Studies; Kidney; Kidney Diseases; Knowledge; Link; Natural History; Normal tissue morphology; Online Systems; Oranges; Outcome; Outcomes Research; Pathway interactions; Patient-Focused Outcomes; Patients; Peer Review; Pharmaceutical Preparations; Phase; Phenotype; Prevention; Protocols documentation; Publications; Registries; Research; Research Institute; Research Personnel; Research Support; Resources; Sampling; Services; Site; System; Tissues; Training and Education; Translational Research; Translations; Transplantation; Urine; base; biobank; catalyst; clinical database; clinical investigation; cloud based; data acquisition; data mining; design; flexibility; follow-up; improved outcome; injury and repair; insight; international center; investigator training; mobile application; multiple data sources; novel; pre-clinical; repository; research study; response; symposium; tool; trial design

Project Summary Clinical and translational research in acute kidney injury (AKI) requires access to well characterized patients with longitudinal follow up coupled with biological samples enabling investigators to probe the underlying mechanisms and pathways contributing to outcomes. The specific aims of the Resource for Clinical Studies of AKI (Core A) are to (i) facilitate and support the design and conduct of clinical research in AKI with appropriate tools to collect and record information for detailed phenotypic characterization of patients through the course of AKI, (ii) provide access to comprehensive datasets of well characterized patients with and without AKI, and (iii) provide a biological sample repository that includes human kidney tissue, blood and urine, linked to an accessible clinical database of patients with and without AKI to enable translational research studies. This core will specifically provide investigators access to patients with AKI through an established international network of collaborating investigators who are contributing to an ongoing registry of AKI in the ICU setting currently with over 2,200 patients. Core A is designed to facilitate both hypothesis-driven and hypothesis-generating clinical research by providing essential resources for clinical investigation and enhancing interactions with a large worldwide network of investigators and centers focused on AKI. Since its inception the Core has been very successful in supporting investigators for clinical and translational research. We have established a robust data management system and database of patients with AKI that is flexible in accommodating the research objectives of individual investigators and collaborating centers. A new service being offered by Core A is the addition of human kidney tissues along with biological samples (blood, urine and DNA) from patients with and without AKI and healthy controls. Over the last 4 years, Core A has been highly productive in assisting multiple facets of clinical research supporting 72 investigators including 8 pilot and catalyst awardees and 111 different projects. These combined efforts have resulted in 40 peer-reviewed publications. All services provided by Core A are being utilized by our investigator base. We envision that these rich resources will continue to enable interdisciplinary clinical investigation in AKI to advance our understanding of the natural history and pathophysiology of human AKI. We are confident that Core A in conjunction with the existing resources at UAB and UCSD and other cores within the O'Brien Center will accelerate the translation of new investigative insights towards improving outcomes for patients with AKI.

项目概要 急性肾损伤 (AKI) 的临床和转化研究需要获得充分表征的数据 对患者进行纵向随访并结合生物样本，使研究人员能够探究 促成结果的基本机制和途径。临床资源的具体目标 AKI 研究（核心 A）是为了 (i) 促进和支持 AKI 临床研究的设计和实施， 通过适当的工具来收集和记录患者详细表型特征的信息 AKI 的病程，(ii) 提供对具有明确特征的患者的综合数据集的访问， 没有 AKI，并且 (iii) 提供包含人体肾组织、血液和尿液的生物样本库， 链接到患有和不患有 AKI 的患者的可访问临床数据库，以实现转化研究 研究。该核心将专门为研究人员提供通过已建立的机制接触 AKI 患者的机会 国际合作研究人员网络，致力于在 ICU 持续登记 AKI 目前有超过 2,200 名患者。核心 A 旨在促进假设驱动和 通过为临床调查提供必要的资源来进行假设生成的临床研究 加强与专注于 AKI 的全球大型研究人员和中心网络的互动。 自成立以来，核心在支持研究人员的临床和 转化研究。我们建立了强大的数据管理系统和患者数据库 AKI 可以灵活地适应个体研究者的研究目标和协作 中心。 Core A 提供的一项新服务是添加人体肾组织以及生物 来自患有或未患有 AKI 的患者以及健康对照者的样本（血液、尿液和 DNA）。过去 4 年里， 核心 A 在协助临床研究的多个方面方面卓有成效，为 72 名研究人员提供支持 包括 8 个试点和催化剂获奖者以及 111 个不同的项目。这些共同努力已取得 40 同行评审的出版物。我们的调查员基地正在使用 Core A 提供的所有服务。我们 预计这些丰富的资源将继续支持 AKI 的跨学科临床研究 增进我们对人类 AKI 的自然史和病理生理学的理解。我们有信心 核心 A 与 UAB 和 UCSD 的现有资源以及奥布莱恩中心内的其他核心相结合 将加速新研究见解的转化，以改善 AKI 患者的治疗结果。