A Data Coordinating Center for ENCODE

ENCODE 数据协调中心

• 批准号: 10240216
• 负责人: J. Michael Cherry
• 金额: $ 479.92万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10240216
• 关键词: Biological; Biological Assay; Biomedical Research; Cells; Communities; Computer Analysis; Computer software; Data; Data Coordinating Center; Development; Disease; Documentation; Elements; Goals; Gold; Health; Human; Human Characteristics; Human Genome; Laboratories; Metadata; Methods; Modeling; Participant; Procedures; Process; Production; Public Health; Quality Control; Reproducibility; Sampling; Structure; Tissues; Validation; biological research; complex data; data analysis pipeline; data resource; data standards; data submission; data warehouse; design; distributed data; experience; genomic data; meetings; service organization; tool; verification and validation; webinar

Project Summary The goals of the ENCODE Data Coordinating Center (DCC) is to support the ENCODE Consortium by defining and establishing a strategy that connects all participants to the data and by creating avenues of access that distribute these data to the greater biological research community. The ENCODE Consortium brings together laboratories that generate complex data types via experimental assays with laboratories that integrate these unique data using computational analyses to discover how chromosomal elements function together to define human cells and tissues. The DCC's participation enhances the data created by these laboratories through the creation of structured procedures for the verification and validation of all submitted data and providing processes for the documentation of metadata that describe each biological sample and assay method. To facilitate access to all the data created the DCC will construct a state of the art data warehouse. The DCC will design and development robust software to enhance the data submission and unified data processing pipelines, the organization and access to metadata and the data warehouse. In addition, we will develop and maintain the ENCODE Portal that will be the primary entry point to the wealth of experimentally determined information as well as results of computational analyses. The Portal will integrate these data resources and make them available via enhanced search and browsing capabilities. Tools will be implemented to aid discovery by both experienced bioinformaticians and naïve laboratory staff. The DCC will evolve into a substantial service organization allowing biomedical research to take full advance of the ENCODE results. To this end the DCC will provide documentation via many media including written documentation, video tutorials, webinars, and meeting presentations. The DCC, DAC, production laboratories and AWG will be tightly woven together to create the ENCODE Consortium.

项目概要 ENCODE 数据协调中心 (DCC) 的目标是通过定义 制定将所有参与者连接到数据的策略，并创建访问途径 将这些数据分发给 ENCODE 联盟汇集的更大的生物研究界。 通过实验分析生成复杂数据类型的实验室以及集成这些数据类型的实验室 使用计算分析的独特数据来发现染色体元素如何一起发挥作用来定义 DCC 的参与增强了这些实验室通过以下方法创建的数据。 创建结构化程序来验证和确认所有提交的数据并提供 描述每个生物样本和测定方法的元数据的记录过程。 方便访问创建的所有数据 DCC 将构建最先进的数据仓库。 设计和开发强大的软件以增强数据提交和统一数据处理 此外，我们还将开发和访问元数据和数据仓库。 维护 ENCODE 门户，该门户将成为通过实验确定的财富的主要入口点 该门户将整合这些数据资源和信息以及计算分析结果。 通过增强的搜索和浏览功能使它们可用 将实施工具来提供帮助。 由经验丰富的生物信息学家和天真的实验室工作人员共同发现的 DCC 将发展成为一个 实质性服务组织允许生物医学研究充分推进 ENCODE 结果。 为此，DCC 将通过多种媒体提供文档，包括书面文档、视频教程、 DCC、DAC、生产实验室和 AWG 将紧密结合在一起进行网络研讨会和会议演示。 共同创建 ENCODE 联盟。