Analytic Support for NHANES Allergen Component (NHANES)

NHANES 过敏原成分 (NHANES) 的分析支持

• 批准号: 9171960
• 负责人: RICHARD COHN
• 金额: $ 6.75万
• 依托单位: SOCIAL AND SCIENTIFIC SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-10 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9171960
• 关键词: Address; Allergens; Allergic; Allergic Disease; Asthma; Cardiovascular Diseases; Centers for Disease Control and Prevention (U.S.); Clinical; Complex; Consensus; Contractor; Data; Data Collection; Data Files; Data Set; Development; Disease; Dust; Elderly; Endotoxins; Ensure; Food; Household; Hygiene; IgE; Institution; Journals; Knowledge; Lead; Lipids; London; Manuscripts; Measurement; Mining; Modification; National Health and Nutrition Examination Survey; National Institute of Environmental Health Sciences; Obesity; Outcome; Outcome Measure; Patient Self-Report; Pesticides; Plasma; Preparation; Prevention strategy; Publications; Research; Research Personnel; Sample Size; Seminal; Symptoms; Testing; Update; Vitamin D; design; environmental agent; environmental allergen; food allergen; inflammatory marker; meetings; phthalates; programs; research clinical testing; respiratory; user-friendly

The contractor will provide analytic support and expertise for the design and implementation of statistical analyses and the development of manuscripts that analyze the relation of environmental agents (such as allergens) in the development of disease. NIEHS has invested in augmented data collection for the 2005-2006 NHANES to include enhanced sample size, self-reported exposure questions, clinical testing for allergen sensitivity, IgE measurement, testing for exposures in dust, food and environmental allergens. These nationally representative data can uniquely address outstanding clinical questions about the relationship between allergen, exposure, sensitivity and clinical outcomes. The need is to prepare a user-friendly, standard analytic data file and execute an analysis plan that fully mines the richness of these data. Statistical and analytic support under this SP will produce analysis of NHANES 2005-2006 data leading to a better understanding of the complex relationships between allergen and endotoxin exposures, allergic sensitization, and disease, and this knowledge will eventually lead to effective strategies for the prevention and treatment of asthma and other allergic diseases. The overall purpose of this task is to expedite analyses of the NIEHS/NHANES allergen data and produce seminal publications as quickly as possible. Preparation and support for analyses involves several distinct but related activities: a) conduct coordinative meetings of early users (analytic team) of the NIEHS/NHANES data, b) presentation and analyses of preliminary summary NHANES data, c) prepare a mock data set, d) evaluate NIEHS/NHANES data for approval for public release, and e) prepare an analytic data set. In order to accomplish activity e), it will be necessary to achieve consensus among the researchers on appropriate derived variables, including establishing cut-off values for continuous variables and defining combinations of raw measurements into composite outcomes measures. Task 1 requires coordination of a uniquely complex set of activities among collaborating researchers from multiple institutions and support for their diverse analytic needs. An advanced senior level program manager is needed to oversee this effort.

承包商将为统计分析的设计和实施提供分析支持和专业知识，以及分析环境药物（例如过敏原）在疾病发展中的关系的手稿。 NIEHS已投资于2005 - 2006年NHANES的增强数据收集，包括增强样本量，自我报告的暴露问题，过敏原敏感性的临床测试，IGE测量，测试粉尘，食物和环境过敏原中的暴露。这些全国代表性的数据可以独特地解决有关过敏原，暴露，敏感性和临床结果之间关系的杰出临床问题。需要准备一个用户友好的标准分析数据文件，并执行一个分析计划，以完全挖掘这些数据的丰富性。此SP下的统计和分析支持将对NHANES 2005-2006的数据进行分析，从而更好地了解过敏原与内毒素暴露，过敏反应和疾病之间的复杂关系，并且这些知识最终将为预防和治疗哮喘和其他过敏性疾病提供有效的策略。 这项任务的总体目的是加快对NIEHS/NHANES过敏原数据的分析，并尽快产生开创性出版物。分析的准备和支持涉及几个不同但相关的活动：a）NIEHS/NHANES数据的早期用户（分析团队）进行协调会议，b）介绍和分析初步摘要NHANES数据，c）准备模拟数据集，准备一个模拟数据集，d）评估NIEHS/NHANES数据以供公众释放进行公共释放，并准备公众释放和分析。为了完成活动e），有必要就适当的衍生变量达成共识，包括建立连续变量的截止值，并将原始测量结果定义为复合结果测量。任务1要求协调多个机构的合作研究人员中的一系列独特的复杂活动，并支持其各种分析需求。需要一名高级高级计划经理来监督这项工作。