International Conference on Grampositive Pathogens

国际革兰氏阳性病原体会议

• 批准号: 8785549
• 负责人: PAUL D FEY
• 金额: $ 0.5万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-05 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8785549
• 关键词: Adult; Antibiotic Resistance; Antibiotic-Associated Colitis; Antibiotics; Award; Bacteria; Biology; Cell Communication; Cell Wall; Cells; Clostridium difficile; Collaborations; Communities; Data; Enterocolitis; Environment; Epidemic; Epidemiology; Fees; Fostering; Funding; Gram-Negative Bacteria; Grant; Health care facility; Hospitals; Individual; Infection; Institution; International; Knowledge; Medical center; Membrane; Nebraska; Necrotizing fasciitis; Oral; Organism; Paris, France; Participant; Pathogenesis; Postdoctoral Fellow; Protein Biosynthesis; Protein Secretion; Protocols documentation; Regimen; Research; Research Personnel; Schools; Science; Scientist; Senior Scientist; Skin Tissue; Soft Tissue Infections; Staging; Travel; United States; Universities; Woman; base; career; graduate student; interest; meetings; member; methicillin resistant Staphylococcus aureus; mortality; novel therapeutics; pathogen; posters; public health relevance; symposium; undergraduate student

DESCRIPTION (provided by applicant): The International Conference on Gram-Positive Pathogens (ICGPP) brings together scientists at all stages of their careers to exchange ideas and strategies based on their shared interests in Gram- positive pathogens. This conference, initially held in 2006 and then continued in 2008, 2010, and 2012 as a result of participant enthusiasm, grew out of collaborations between investigators at the University of Nebraska Medical Center and other academic institutions in the great plains region of the United States. The overarching benefit of ICGPP is the opportunity for investigators to share the science, approaches, and protocols that are unique to Gram-positive organisms in contrast to Gram- negative bacteria. While Gram-positive pathogens cause a myriad of unique infections, ranging from antibiotic-associated colitis to necrotizing fasciitis, fundamental aspects of activities that include protein secretion across single membranes, cell wall biosynthesis and protein anchoring, and cell-cell communication are shared between this group of medically important pathogens. The impact of Gram-positive infections continues to grow and antibiotic resistance remains a significant threat. As an example, Clostridium difficile enterocolitis, once primarily associated with antibiotic use in hospitals, is now found in young, healthy adults that do not have an epidemiological relationship to a healthcare facility. Recent data suggests that infections caused by C. difficile are the leading cause of mortality among antibiotic-resistant bacteria in the US. In addition, community-acquired methicillin- resistant Staphylococcus aureus (CA-MRSA) strain USA300 has reached epidemic levels and is causing skin and soft tissue infections in schools, locker rooms, and hospitals in otherwise healthy individuals. This R13 application is requesting funds to support the ICGPP to be held in Omaha, NE during the dates of October 12-15, 2014. Our current organizing committee is comprised of eight members from various academic institutions, and all are past attendees and have been involved in the planning stages of this conference. Although other meetings exist in the US that present various aspects of bacterial pathogenesis or prokaryotic biology, this is the only meeting focusing specifically on Gram-positive pathogenesis and biology, and which provides a collegial and supporting environment that fosters interactions between established investigators and junior scientists. Young scientists have the option of presenting their research in either poster or oral format and importantly, in 2012, 40 trainees gave oral research presentations. Five internationally known scientists have already agreed to give keynote presentations at the 2014 ICGPP: Drs. Andrew Camilli (Tufts University), Jean Lee (Harvard University and Brigham and Women's Hospital), Bruno Dupuy (Institut Pasteur in Paris, France), Darren Higgins (Harvard University), and Kelly Doran (San Diego State University). To keep registration fees low for participants and to encourage the engagement of young investigators, we request funds to support travel of our five keynote speakers and for 17 travel grants that will be awarded to pre and post-doctoral trainees.

描述（由申请人提供）：革兰氏阳性病原体国际会议（ICGPP）将其职业的各个阶段的科学家汇集在一起​​，以基于他们在革兰氏阴性病原体中的共同利益来交流思想和策略。这次会议最初于2006年举行，然后由于参与者的热情而在2008年，2010年和2012年持续，这是由于内布拉斯加州医学中心大学医学中心的调查人员与美国大平原地区的其他学术机构之间的合作发展。 ICGPP的总体好处是研究人员共享革兰氏阳性生物体独有的科学，方法和方案，与革兰氏阴性细菌相比。革兰氏阳性病原体引起了无数独特的感染，从抗生素相关的结肠炎到坏死性筋膜炎，这是活动的基本方面 包括跨单个膜的蛋白质分泌，细胞壁生物合成和蛋白质锚定，以及这组医学上重要的病原体之间共享细胞 - 细胞通信。革兰氏阳性感染的影响继续增长，抗生素耐药性仍然是一个重大威胁。例如，现在在与医疗机构没有流行病学关系的年轻，健康的成年人中发现，曾经在医院中主要与抗生素使用有关的艰难梭菌小肠结肠炎。最近的数据表明，艰难梭菌引起的感染是美国抗生素耐药细菌死亡的主要原因。此外，社区获得的甲氧西林金黄色葡萄球菌（CA-MRSA）USA300菌株已经达到了流行水平，并在学校，更衣室和其他健康个体的医院中引起了皮肤和软组织感染。该R13申请要求资金支持2014年10月12日至15日在美国新东北奥马哈举行的ICGPP。我们当前的组织委员会由来自各个学术机构的八名成员组成，所有这些成员都是过去的与会者，并且参与了这次会议的计划阶段。尽管在美国存在其他会议，这些会议介绍了细菌发病机理或原核生物学的各个方面，但这是唯一专门针对的会议 革兰氏阳性的发病机理和生物学，并提供了一个合作和支持的环境，从而促进了既定研究人员与初级科学家之间的相互作用。年轻科学家可以选择以海报或口头形式进行研究，重要的是，2012年，有40名学员进行了口头研究演讲。五位国际知名的科学家已经同意在2014年ICGPP：DRS上进行主题演讲。安德鲁·卡米利（Tufts University），让·李（Jean Lee）（哈佛大学和杨百翰及妇女医院），布鲁诺·杜普伊（Bruno Dupuy）（法国巴黎的帕斯德学院），达伦·希金斯（Darren Higgins）（哈佛大学）和凯利·多兰（Kelly Doran）（圣地亚哥州立大学）。为了使参与者保持较低的注册费并鼓励年轻调查人员的参与，我们要求资金支持我们的五位主题演讲者的旅行，并为17个旅行补助金提供授予前后的学员。