Prostate Cancer Studies

前列腺癌研究

• 批准号: 10263753
• 负责人: Michael Cook
• 金额: $ 37.18万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263753
• 关键词: 8q24; Africa; African; Biochemical; Biological; Biological Markers; Case Series; Central obesity; Clinical; Consent; Data; Diagnosis; Epidemiology; Genetic; Ghana; Hormonal; Human; Human Genetics; Insulin; Insulin-Like Growth Factor I; Interview; Life Style; Link; Low-Density Lipoproteins; Malignant neoplasm of prostate; Meta-Analysis; Methodological Studies; Molecular; Molecular Genetics; Nature; Nutritional; Obesity; Population; Predisposition; Prevalence; Prostate; Prostatic Diseases; Publishing; Risk; Risk Factors; Sampling; Series; Surveys; Variant; base; cancer type; design; genetic profiling; genome wide association study; insight; men; metabolic profile; multidisciplinary; novel; population based; population survey; prostate cancer risk; recruit

In Ghana, Africa, we have conducted a population-based survey of men to assess the population prevalence of prostatic disease (CAS ID:01130). We have also collected consented into the study a clinical series of men diagnosed with prostate cancer. This dynamic epidemiologic design of a population survey combined with a larger case series, is enabling us to assess the burden of prostate cancer in African men as well as assess risk factors associated with prostate cancer in an important and understudied population. Biological samples collected from the 1,038 healthy men in the population survey component will allow us to establish the nutritional, hormonal, and genetic profiles of African men. In addition, linking interview data from these 1,038 healthy subjects with biomarkers will produce insights into whether westernization in African men is associated with an adverse metabolic profile (obesity; abdominal obesity; higher levels of insulin, low-density lipoprotein, and insulin-like growth factor I), which has been associated with excess prostate cancer risk. The additional 677 prostate cancer cases that we recruited through the clinical component has enabled us to conduct a genome wide association study (GWAS) of prostate cancer in this unique population (published in Human Genetics). In addition, we have sequenced the 8q24 region and identified several novel variants (published in Prostate) as well contributed to a pooled fine-mapping study of this region in African Men (published in JNCI) and an imputation and subset based meta-analysis of chr5p15.33 across multiple cancer types (published in Human Molecular Genetics). We have also contributed data to multi-racial GWAS and have identified 23 novel genetic (SNP) associations with prostate cancer (published in Nature Genetics). We have recently contributed to an integrative analysis to identify candidate functional SNPs at prostate cancer susceptibility regions of the geonome (published in Human Molecular Genetics).

在非洲加纳，我们对男性进行了一项基于人群的调查，以评估前列腺疾病的人群患病率（CAS ID：01130）。我们还收集了一系列被诊断患有前列腺癌的男性并同意参与这项研究。这种人口调查的动态流行病学设计与更大的病例系列相结合，使我们能够评估非洲男性前列腺癌的负担，并评估重要且未充分研究的人群中与前列腺癌相关的危险因素。在人口调查部分，从 1,038 名健康男性中收集的生物样本将使我们能够建立非洲男性的营养、荷尔蒙和遗传特征。此外，将这 1,038 名健康受试者的访谈数据与生物标志物联系起来，将深入了解非洲男性的西化是否与不良代谢特征（肥胖、腹部肥胖、较高水平的胰岛素、低密度脂蛋白和胰岛素样生长）相关。因子 I），它与前列腺癌风险过高有关。我们通过临床部分招募的另外 677 例前列腺癌病例使我们能够在这个独特人群中进行前列腺癌的全基因组关联研究 (GWAS)（发表在《人类遗传学》上）。此外，我们对 8q24 区域进行了测序，并鉴定了几个新的变异（发表在 Prostate 上），并为非洲男性中该区域的汇总精细绘图研究（发表在 JNCI 上）以及基于插补和子集的荟萃分析做出了贡献。 chr5p15.33 跨越多种癌症类型（发表于《人类分子遗传学》）。我们还为多种族 GWAS 提供了数据，并确定了 23 个与前列腺癌新的遗传 (SNP) 关联（发表在 Nature Genetics 上）。我们最近进行了一项综合分析，以确定基因组前列腺癌易感区域的候选功能 SNP（发表于《人类分子遗传学》）。