Translational Vision Science Research at Oregon Health & Science University

俄勒冈健康中心的转化视觉科学研究

• 批准号: 10249949
• 负责人: Yali Jia
• 金额: $ 15.91万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10249949
• 关键词: Health Sciences; Oregon; Research; Universities; vision science

PROJECT SUMMARY The premise of this proposal is that training the next generation of vision scientists in translation of basic science research to clinical and public health interventions will be critical toward advancing the field. Basic scientific and technological advances are occurring at an unprecedented pace. However, our observation has been that ophthalmologists often lack the background to understand how recent basic and clinical research findings may be applied to their practices, and visual scientists often lack adequate perspective to identify gaps in clinical knowledge to guide their research. This application proposes to renew a successful T32 translational vision research training program for students in pre-doctoral training programs in basic or applied science, or postdoctoral fellows at Oregon Health & Science University (OHSU). The overall goal is to prepare individuals for successful academic careers in vision science research through didactic education and intensive mentored research experience in a multidisciplinary environment. The vision research and training environment at OHSU is highly collaborative and interdisciplinary, with strong programmatic support in translation of research from bench to bedside in areas such as gene therapy, molecular genetics, drug development, clinical trials, ophthalmic imaging, and biomedical informatics. The university has top educational programs in clinical ophthalmology and basic visual science, and is consistently ranked in the top 10 nationally in NEI-supported research. This program fills an important gap in education because OHSU is one of the few major academic medical centers in the Pacific Northwest, yet there are no other programs to support didactic training in visual science research here. We will continue to leverage the existing infrastructure at OHSU to allow more pre- doctoral and post-doctoral trainees to benefit from and contribute toward this research and educational environment. Since 2013, we have supported 13 trainees (including 2 under-represented minorities and 3 women) who have published 60 peer-reviewed papers with their mentors in leading journals. Specifically, we propose to continue this T32 program for 3 pre-doctoral and 1 post-doctoral trainee, which will be integrated with ongoing research and existing OHSU graduate programs in basic science. Training consists of six key components: (1) research projects with mentors and collaborators, (2) a didactic course covering fundamentals of basic, clinical, and translational vision science, (3) twice-monthly vision research seminars for discussion of ongoing research by trainees and faculty, along with weekly half-day teaching sessions, (4) institution-wide education and career development activities, (5) a grant mentorship program to teach and support trainees as they apply for their own, independent funding and (6) training in responsible conduct of research. We believe this program will continue to provide a clinical perspective to trainees with existing backgrounds in basic science. OHSU is a setting where rigorous training in basic and clinical research through this T32 program will provide a generation of young researchers with the tools to optimize translational vision research.

项目概要 该提案的前提是培训下一代视觉科学家翻译基础知识 临床和公共卫生干预的科学研究对于推进该领域至关重要。基本的 科学和技术正在以前所未有的速度进步。然而，我们的观察发现 眼科医生往往缺乏了解最新基础和临床研究的背景 研究结果可能会应用于他们的实践，而视觉科学家往往缺乏足够的视角来识别差距 临床知识来指导他们的研究。此申请旨在续订成功的 T32 翻译 为参加基础科学或应用科学博士前培训课程的学生提供视觉研究培训计划，或 俄勒冈健康与科学大学 (OHSU) 博士后研究员。总体目标是让个人做好准备 通过教学教育和强化指导，在视觉科学研究领域取得成功的学术生涯 在多学科环境中的研究经验。 OHSU 的视觉研究和培训环境 具有高度协作性和跨学科性，在研究成果转化方面拥有强大的程序支持 在基因治疗、分子遗传学、药物开发、临床试验等领域从实验室到临床 眼科成像和生物医学信息学。该大学拥有顶尖的临床教育课程 眼科和基础视觉科学，在NEI支持的全国排名中一直排名前10 研究。该项目填补了教育领域的一个重要空白，因为 OHSU 是少数几个主要学术机构之一 太平洋西北地区的医疗中心，但没有其他计划来支持视觉教学培训 科学研究在这里。我们将继续利用 OHSU 的现有基础设施，以允许更多预 博士和博士后学员从这项研究和教育中受益并做出贡献 环境。自 2013 年以来，我们已支持 13 名受训人员（包括 2 名代表性不足的少数族裔和 3 名 女性）与导师在领先期刊上发表了 60 篇同行评审论文。具体来说，我们 建议继续开展T32项目，招收3名博士前和1名博士后，该项目将被整合 正在进行的研究和现有 OHSU 基础科学研究生课程。培训包括六大重点 组成部分：(1) 与导师和合作者合作的研究项目，(2) 涵盖基础知识的教学课程 基础、临床和转化视觉科学，(3) 每月两次的视觉研究研讨会，讨论 学员和教师正在进行的研究，以及每周半天的教学课程，(4) 全机构范围 教育和职业发展活动，(5) 一项赠款指导计划，以教导和支持受训者 他们申请自己的、独立的资金和（6）负责任的研究行为的培训。我们相信 该计划将继续为具有基础基础知识背景的学员提供临床视角 科学。 OHSU 是一个通过 T32 计划进行基础和临床研究严格培训的环境 为一代年轻研究人员提供优化转化视觉研究的工具。