Visual Science Training Grant

视觉科学培训补助金

• 批准号: 10250449
• 负责人: Z JIMMY ZHOU
• 金额: $ 15.29万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10250449
• 关键词: Grant; Training; vision science

Program Director/Principal Investigator (Last, First, Middle): Zhou, Z. Jimmy Abstract This application proposes to continue an integrative training program in visual science research at Yale University School of Medicine, with a special emphasis on visual neuroscience. The goal of this program is to foster interdisciplinary approaches to visual neuroscience that will interface with molecular genetics and clinical medicine in the areas of development, organization, function, degeneration, and regeneration in the eye and the central visual system. Fourteen faculty preceptors from six basic and clinical departments participate in this multidisciplinary program. These faculty members lead vibrant vision research programs in a vision research community at Yale that has undergone an exciting phase of revitalization and expansion, and that has attracted an increasing number of outstanding graduate students and postdoctoral fellows. The proposed training program offers both depth and breadth. The depth derives from its substantive focus on the neuroscience of the eye and the visual system. The breadth of the program derives from the diversity of approaches, spanning molecular, developmental, systems, cognitive and theoretical neuroscience, as well as from the range of experimental models used in these studies, spanning drosophila, zebrafish, rodents, and primates. Faculty interests range from retinal development and degeneration, retinal physiology and circuits to visual cortical function and visual behavior. Methodologies include cloning; cell culture; immunocytochemistry; in situ hybridization; gene transfection and transgenic technology, electron and two photon microscopy; optogenetics, patch-clamp and multielectrode recording; electroretinograph, optical imaging; biochemistry and molecular analyses; psycho-pharmacology; rodent, monkey and human behavior; in vivo extracellular recording in behaving animals; and fMRI and PET imaging in human subjects. Two predoctoral and two postdoctoral positions are requested. Trainees will be selected from a variety of backgrounds in biological sciences on the basis of their potential for excellence and leadership in research by an Executive Committee. Mentors are Ph.D.s and M.D.s. with NEI and other NIH institute grants or NEI related research foci. Training includes coursework, intensive research apprentice-ship, structured seminar programs, laboratory and departmental presentations of research progress, and instructions on responsible research conduct. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

项目总监/首席研究员（后、前、中）：Zhou, Z. Jimmy 抽象的 该申请建议继续在耶鲁大学进行视觉科学研究的综合培训计划 大学医学院，特别强调视觉神经科学。该计划的目标是 促进视觉神经科学的跨学科方法，与分子遗传学和临床相结合 眼睛发育、组织、功能、退化和再生领域的医学 中央视觉系统。来自6个基础科室和临床科室的14名教师导师参加 这个多学科项目。这些教师在愿景中领导充满活力的愿景研究项目 耶鲁大学的研究团体经历了令人兴奋的振兴和扩张阶段，并且 吸引了越来越多的优秀研究生和博士后。拟议的 培训计划既有深度又有广度。深度源于其对以下内容的实质性关注： 眼睛和视觉系统的神经科学。该计划的广度源于多样性 方法，涵盖分子、发育、系统、认知和理论神经科学，以及 这些研究中使用的实验模型范围广泛，涵盖果蝇、斑马鱼、啮齿动物和 灵长类动物。教师的兴趣范围从视网膜发育和变性、视网膜生理学和电路到 视觉皮层功能和视觉行为。方法包括克隆；细胞培养；免疫细胞化学； 原位杂交；基因转染和转基因技术、电子和双光子显微镜； 光遗传学、膜片钳和多电极记录；视网膜电图仪、光学成像；生物化学和 分子分析；精神药理学；啮齿动物、猴子和人类行为；体内 细胞外 记录动物的行为；以及人体受试者的 fMRI 和 PET 成像。 需要两个博士前职位和两个博士后职位。实习生将从各种类型中选拔 生物科学背景，基于其在研究方面的卓越潜力和领导力 执行委员会。导师是博士和医学博士。与 NEI 和其他 NIH 机构补助金或 NEI 相关 研究重点。培训包括课程作业、强化研究学徒、结构化研讨会项目、 实验室和部门的研究进展介绍以及负责任研究的说明 执行。 PHS 398/2590（修订版 06/09） 页面延续 格式页面