Evaluating Atlas-Driven Imaging for Clinical Applications in Cleft Palate Care

评估 Atlas 驱动成像在腭裂护理中的临床应用

• 批准号: 10249446
• 负责人: Jamie L Perry
• 金额: $ 2.99万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10249446
• 关键词: 3-Dimensional; 8 year old; Affect; Age; Anatomy; Area; Atlases; Biomechanics; Birth; Caring; Characteristics; Child; Cleft Palate; Clinical; Complex; Congenital Abnormality; Data; Dependence; Disease; Effectiveness; Elements; Endoscopy; Event; Functional disorder; Geographic Locations; Geometry; Goals; Image; Imaging Techniques; Individual; Investigation; Label; Language Development; Link; Literature; Location; Magnetic Resonance Imaging; Medical Care Costs; Monitor; Motion; Movement; Muscle; Muscle function; Nose; Operative Surgical Procedures; Outcome; Patients; Pattern; Performance; Physiological; Population; Positioning Attribute; Premaxillary palate; Process; Protocols documentation; Race; Recording of previous events; Research; Resolution; Sampling; Secondary to; Series; Site; Speech; Speech Development; Speech Disorders; Speed; Structure; Subgroup; Surgical Management; System; Techniques; Technology; Three-Dimensional Imaging; Time; United States; Variant; Velopharyngeal Insufficiency; Visualization; aged; base; cleft lip and palate; clinical application; clinically relevant; diagnostic technologies; imaging modality; improved; in vivo; insight; palate repair; psychosocial development; recruit; repaired; sex; soft tissue; spatiotemporal; temporal measurement; tool

PROJECT SUMMARY Cleft lip and palate is the most prevalent birth defect in the United States affecting one out of every 577 births. Despite advances in surgery, it is estimated that 25-38% of children with a repaired cleft palate will continue to have hypernasal speech due to insufficient velopharyngeal closure, requiring additional surgeries. Although nasal endoscopy is frequently used to determine the type of surgery, it provides only limited views of the movements of speech. Insufficient information is available from current diagnostic technologies to visualize the location of muscles and their quantitative functional arrangement in the child. Magnetic resonance imaging (MRI) provides excellent visualization of soft tissue structures, such as muscles, but has traditionally been too slow to capture speech dynamics where complete contractions may occur in 100 ms. The current proposal develops a dynamic MRI imaging method that can image the full vocal tract in 3D+time with high spatial and high temporal resolution, achieving 166 frames per second (FPS) for the entire volume. Specifically, a dynamic speech imaging technique will be developed that is suitable for application in children aged 5-8 years old, a critical age range for re-repair of cleft palate in secondary surgical management. The technique integrates a spatiotemporal atlas that describes the mean motions across a population of healthy children for particular speech samples. The imaging technique leverages the atlas to: improve the quality of the reconstructed images, automatically label edges for quantitative analysis, and focuses the analysis on variances in motion from one subject compared to the healthy atlas. In order to examine the dependency of the population mean atlas on sex, race, and dialect, spatiotemporal atlases will be developed at three different geographical sites, with 40 healthy children ages 5-8 years old at each site, with equal numbers of both sexes and equal numbers of two races. Additionally, we will recruit 45 cleft palate patients ages 5-8 years old following cleft palate repair with and without velopharyngeal insufficiency with resulting hypernasality. We will apply our imaging technique to examine temporal characteristics of velopharyngeal muscle function, determining movement differences related to hypernasality.

项目概要 唇裂和腭裂是美国最常见的出生缺陷，每 577 人中就有一人患有唇裂和腭裂 出生。尽管手术取得了进步，但据估计，25-38% 的腭裂修复儿童将 由于腭咽闭合不充分，继续出现鼻音过多的言语，需要额外的 手术。尽管鼻内窥镜检查经常用于确定手术类型，但它仅提供 对言语运动的有限看法。当前的诊断信息不足 可视化儿童肌肉位置及其定量功能排列的技术。 磁共振成像 (MRI) 可提供软组织结构的出色可视化，例如 肌肉，但传统上太慢，无法捕捉完全收缩可能的语音动态 发生在 100 毫秒内。 目前的提案开发了一种动态 MRI 成像方法，可以对整个声道进行成像 3D+时间，具有高空间和高时间分辨率，实现每秒 166 帧 (FPS) 整个卷。具体来说，将开发一种适用于的动态语音成像技术 5-8岁儿童的应用，这是中学腭裂再修复的关键年龄范围 手术管理。该技术集成了描述平均运动的时空图集 在健康儿童群体中获取特定的语音样本。成像技术利用 图集：提高重建图像的质量，自动标记边缘以进行定量 分析，并将分析重点放在一个受试者与健康图谱相比的运动差异上。 为了考察人口平均图谱对性别、种族、方言的依赖性，时空 地图集将在三个不同的地理位置制作，涉及 40 名 5 至 8 岁的健康儿童 在每个地点，男女和两个种族的人数相等。此外，我们还将招募 45 名 5-8 岁的腭裂患者接受或不接受腭咽修复术 不足导致鼻音过多。我们将应用我们的成像技术来检查时间 腭咽肌功能的特征，确定与以下相关的运动差异 鼻音过多。