Methodologic Core

方法论核心

基本信息

批准号：
10248404
负责人：
Michael J Econs
金额：
$ 38.96万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-19 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10248404
关键词：
Back Basic Science Big Data Bioinformatics Biometry Biostatistical Methods Characteristics Chronic Disease Classification Clinical Clinical Data Clinical Investigator Clinical Research Clinical Trials Design Collaborations Communication Communities Complex Computational Biology Computational algorithm Data Data Set Data Sources Databases Development Diagnosis Disease Distant Electronic Health Record Evaluation Functional disorder Funding Gastrointestinal tract structure Genetic Genomics Genotype Goals Health Health Care Costs Healthcare Systems Homeostasis Hormones Human Impairment Indiana Individual Information Technology Institutes Interdisciplinary Study Investigation Kidney Knowledge Discovery Lead Link Literature Mechanics Medical Medical Informatics Methodology Methods Minerals Modernization Molecular Morphology Multiomic Data Muscle Musculoskeletal Musculoskeletal Diseases Nervous system structure Organ Outcome Outcomes Research Pain Pathogenesis Patients Phenotype Physical Function Precision Health Prevention Process Proteomics Public Domains Publishing Research Research Design Research Infrastructure Research Personnel Research Project Grants Research Support Resources Sampling Science Source Speed Standardization Statistical Data Interpretation Symptoms System Systems Biology Techniques Technology Technology Transfer Therapeutic Training Universities Work base bench to bedside biobank biological systems biomarker development biomarker discovery blood resource bone bone cell clinical center complex data computable phenotypes data integration design disability health information technology imaging modality improved industry partner innovation member metabolomics molecular phenotype multidisciplinary new technology new therapeutic target novel personalized medicine precision medicine prospective recruit sample collection success text searching tissue resource tool

项目摘要

Musculoskeletal disorders are common and result in significant disability and health care costs. Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust clinical research infrastructure and improved classification of the various disorders. The latter is critical to precision or personalized medicine approaches as many musculoskeletal disorders have common clinical presentations of pain and impaired physical function despite diverse pathophysiology. Furthermore, research to date often focuses on bone or muscle and not how they interact. The overarching theme of the Indiana Core Center for Clinical Research (ICCCR) is to enhance clinical research in musculoskeletal disorders and to understand the muscle-bone connection by better defining, or phenotyping, this broad class of disorders in order to advance clinical research. The ICCCR will leverage campus resources of our CTSA that includes Indiana and Purdue Universities, our statewide healthcare system IU Health, the Regenstrief Institute's statewide electronic health record system, and the Precision Health Initiative to enhance clinical research. The ICCCR will work with Thematic Teams of multi-disciplinary investigators to create innovative ways to think about musculoskeletal disorder phenotypes. The ICCCR will support individuals to connect investigators and Thematic Teams to the methodologic and resource cores thereby facilitating access to and help in conducting research that 1) utilizes our vast network of electronic health records, omics, and bioinformatics group to create computable, genetic and molecular phenotypes, 2) develops standardized physical function and imaging modalities to develop functional and morphologic phenotypes, and 3) expands the Indiana Biobank's musculoskeletal tissue and blood resources. The ICCCR will work with community and industry partners to facilitate recruitment and technology transfer and provide pilot funding to support new research. In the Methodologic Core, the ICCCR will train, facilitate and support investigators to expand access to biostatical support and project review, enhance clinical research and patient health by leveraging large databases to define and validate computable phenotypes, and accelerate the human to bench and back cycle of musculoskeletal discovery by assisting investigators in state of the art evaluation of musculoskeletal biospecimens. These new and innovative initiatives under the ICCCR will link our musculoskeletal researchers of Indiana Center for Musculoskeletal Research to state of the art resources to identify novel targets for diagnosis and treatment of musculoskeletal disorders. We will challenge the traditional approach of bench to bedside research to instead focus on patient phenotype to bench and back research. This will improve the definition and diagnosis of the many musculoskeletal disorders to diseases that have common pathogenesis and clinical presentations, facilitating personalized medicine by focusing the right treatment for each patient.

肌肉骨骼疾病很常见，会导致严重的残疾和医疗费用。肌肉骨骼疾病诊断和治疗的进步需要强有力的临床研究基础设施和改进各种疾病的分类。后者对于精度或个性化医疗方法，因为许多肌肉骨骼疾病具有共同的临床表现尽管病理生理学不同，但仍存在疼痛和身体功能受损。此外，迄今为止的研究经常重点关注骨骼或肌肉，而不是它们如何相互作用。印第安纳核心中心的总体主题临床研究 (ICCCR) 旨在加强肌肉骨骼疾病的临床研究并了解通过更好地定义或表型分析这一广泛的疾病类别来促进肌肉与骨骼的连接临床研究。 ICCCR 将利用 CTSA 的校园资源，其中包括印第安纳州和普渡大学大学，我们的全州医疗保健系统 IU Health，Regenstrief Institute 的全州电子健康记录系统和精准健康计划，以加强临床研究。 ICCCR 将与由多学科研究人员组成的专题团队创造思考肌肉骨骼的创新方法紊乱表型。 ICCCR 将支持个人将调查人员和专题团队与方法论和资源核心，从而促进访问并帮助开展以下研究：1) 我们庞大的电子健康记录、组学和生物信息学团队网络致力于创建可计算的、遗传的和分子表型，2) 开发标准化的身体功能和成像模式来开发功能和形态表型，3) 扩大印第安纳生物库的肌肉骨骼组织和血液资源。 ICCCR 将与社区和行业合作伙伴合作，促进招聘和技术转让并提供试点资金以支持新研究。在方法论核心中，ICCCR 将培训、便利和支持研究人员，以扩大获得生物统计支持和项目的机会通过利用大型数据库来定义和评估，加强临床研究和患者健康验证可计算的表型，并加速人类的实验和返回周期通过协助研究人员进行最先进的肌肉骨骼评估来发现肌肉骨骼生物样本。 ICCCR 下的这些新的创新举措将把我们的肌肉骨骼联系起来印第安纳肌肉骨骼研究中心的研究人员利用最先进的资源来识别新颖的肌肉骨骼疾病的诊断和治疗目标。我们将挑战传统方法从实验室到床边研究转而关注患者表型到实验室和背部研究。这将改进许多肌肉骨骼疾病对常见疾病的定义和诊断发病机制和临床表现，通过集中正确的治疗来促进个性化医疗每个病人。