Regeneration, Repair and Remodeling of the Lower Urinary Tract

下尿路的再生、修复和重塑

• 批准号: 8925066
• 负责人: Frank C. Marini
• 金额: $ 30.7万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-29 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8925066
• 关键词: American; Animal Model; Awareness; Benign; Bladder; Bladder Diseases; Chronic; Communities; Congenital Disorders; Extramural Activities; Faculty; Funding; Goals; Human; Infection; Inflammation; Interdisciplinary Study; International; Investigation; Lower urinary tract; Modeling; Molecular Target; Mus; Natural regeneration; Quality of life; Research; Research Infrastructure; Research Project Grants; Scientific Advances and Accomplishments; Therapeutic; Tissues; Translational Research; Urology; Work; age related; base; burden of illness; cellular targeting; clinical application; forest; novel; novel strategies; pre-clinical; programs; public health relevance; repaired; response; success; tool; urologic

DESCRIPTION (provided by applicant): This competing renewal is a Scientific Research Project submitted in response to RFA-DK-13-019, and seeks to continue funding of our Planning Center for Interdisciplinary Research in Benign Urology (IR-BU) focused on "Regeneration, repair and remodeling of the lower urinary tract". This application specifically targets the estimated 35 million Americans that suffer from bladder disease, most of which are chronic conditions (i.e., infections, congenital disorders, and inflammation) or aging related that ultimately compromise cellular and tissue integrity leading to reduced bladder function, as well as a diminished quality of life. This proposal to continue our Center in Interdisciplinary Research in Benign Urology (IR-BU) is based on the premise that novel strategies for repair and regeneration of the bladder would have numerous clinical applications to lessen the existing disease burden. As noted herein, this continuation proposal builds logically on prior work and success of the current IR-BU Planning Center. The Specific Aims for our Overall IR-BU Planning Center are: Aim #1: To advance scientific research in interdisciplinary benign urology. Specifically, to begin to identify, validate, and make available to the urologic research community the cutting-edge tools and relevant preclinical animal models required for interdisciplinary investigations into regeneration, repair and remodeling of the lower urinary tract. Aim #2: To increase institutional, national and international awareness of, and involvement in, our IR-BU Center concept and our translational research programs. Aim #3: To build the interdisciplinary core faculty expertise and collaborative infrastructure required for expansion of the extramural funding of benign urology research at Wake Forest, including the eventual establishment of a George M. O'Brien Urology Research Center. The overarching long-term goal of our renewal application is to begin to identify novel molecular and cellular targets in the murine model with potential therapeutic applications for regeneration and repair of the human bladder.

描述（由申请人提供）：这种竞争性更新是一项科学研究项目，该项目是针对RFA-DK-13-019提交的，并试图继续资助我们的良性泌尿外科跨学科研究中心（IR-BU），重点是“重新修复，修复和重塑较低的尿液疗法””。该应用专门针对估计患有膀胱疾病的3500万美国人，其中大多数是慢性病（即感染，先天性疾病和炎症）或与衰老有关 最终损害了细胞和组织完整性，从而导致膀胱功能降低，并降低生活质量。这项提议继续我们的跨学科研究中心 在良性泌尿外科（IR-BU）中，基于以下前提：膀胱修复和再生的新型策略将具有许多临床应用以减轻现有疾病负担。如本文所述，该延续提案在逻辑上建立在当前的IR-BU计划中心的先前工作和成功上。我们整体IR-BU规划中心的具体目的是：目标＃1：促进跨学科良性泌尿外科的科学研究。具体而言，要开始识别，验证和向泌尿科研究界提供跨学科研究所需的尖端工具和相关的临床前动物模型，以对下尿路的再生，修复和改造进行研究。 目标＃2：提高对IR-BU中心概念和转化研究计划的机构，国家和国际意识和参与。 目的＃3：建立跨学科的核心教师专业知识和协作基础设施，以扩大Wake Forest的良性泌尿外科研究的壁外资金，包括最终建立George M. O'Brien泌尿科研究中心。我们更新应用的总体长期目标是开始在鼠模型中鉴定新的分子和细胞靶标，并具有潜在的治疗应用，以再生和修复人膀胱。