Imaging and Radiochemistry Core

成像和放射化学核心

基本信息

批准号：
8961776
负责人：
PAT B ZANZONICO
金额：
$ 21.53万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-27 至 2020-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8961776
关键词：
Animal Model Animals Binding Biological Blood Brain Neoplasms Cancer Model Chemicals Clinical Computer software Cyclotrons Detection Development Diagnostic Imaging Dose Dyes Equipment Fluorescence Functional Imaging Funding Genetic Engineering Hand High Pressure Liquid Chromatography I125 isotope Image Investigation Iodine Kinetics Label Laboratories Lutetium Magnetic Resonance Imaging Malignant Neoplasms Methods Miniature Swine Modality Modeling Molecular Mus Nerve Non-Small-Cell Lung Carcinoma Normal tissue morphology Optics Peptides Positron Positron-Emission Tomography Primary Brain Neoplasms Production Property Radiation Radiochemistry Radioisotopes Radiolabeled Radiometry Reagent Research Research Project Grants Resource Sharing Resources Rodent Running Silicon Dioxide System Tissue Sample Tracer Translations Ultrasonography Xenograft procedure abstracting base cancer imaging data management dosimetry fluorescence imaging imaging system in vivo in vivo Model instrumentation melanoma microPET molecular phenotype nanomedicine nanoparticle optical imaging particle radiotracer screening systems research tool tumor urinary

项目摘要

SHARED RESOURCE CORE - IMAGING AND RADIOCHEMISTRY CORE (CORE B) Project Abstract/Summary The research proposed in the MC2TCN is focused on particle-driven, multi-modality translational developments of radiolabeled ultra-small fluorescent core-shell silica nanoparticles for oncologic diagnostic imaging and therapy. In support of this overarching theme, the Imaging and Radiochemistry Core will provide expertise and state-of-the-art instrumentation in positron emission tomography (PET), fluorescence imaging, and cyclotron production of radionuclides. The specific functions, then, of the Core are to provide for the research projects - both using small animal (rodents) and larger animal models (miniswine) - in vivo structural and functional imaging capabilities, related image display, analysis, and data management tools, cyclotron-produced positron- emitting radioisotopes (e.g., iodine-124 (124I) for synthesis of clinical-grade nanoparticle-based molecular tracers, and compartmental modeling-based kinetic analysis and radiation dosimetry software and expertise.

共享资源核心 - 成像和放射化学核心（核心 B）项目摘要/总结 MC2TCN 中提出的研究重点是粒子驱动的多模态转化开发用于肿瘤诊断成像的放射性标记超小荧光核壳二氧化硅纳米粒子的制备治疗。为了支持这一总体主题，成像和放射化学核心将提供专业知识和最先进的正电子发射断层扫描 (PET)、荧光成像和回旋加速器仪器放射性核素的生产。那么，核心的具体职能是为研究项目提供—— 均使用小型动物（啮齿动物）和大型动物模型（小型猪）——体内结构和功能成像能力、相关图像显示、分析和数据管理工具、回旋加速器产生的正电子发射放射性同位素（例如碘 124 (124I)），用于合成临床级纳米颗粒分子示踪剂、基于房室建模的动力学分析和辐射剂量测定软件和专业知识。