Pre-clinical Assessment Core

临床前评估核心

基本信息

批准号：
10244918
负责人：
Jeryl Jones
金额：
$ 32.67万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10244918
关键词：
Accreditation Agriculture Anatomy Animal Experimentation Animal Model Animals Applications Grants Autopsy Awareness Basic Science Biomedical Engineering Budgets Cadaver Centers of Research Excellence Clinic Clinical Collaborations Computer Models Core Facility Development Devices Elements Equipment Farming environment Fostering Funding Future Goals Harvest Health Health system Histology Human Human Resources Image Image Analysis Immunohistochemistry In Vitro Joints Lead Leadership Learning Link Location Maintenance Marketing Mentors Metals Methodology Mission Modeling Musculoskeletal Operative Surgical Procedures Orthopedics Outcome Patient Care Pilot Projects Pre-Clinical Model Process Protocols documentation Recording of previous events Reproducibility Research Research Personnel Research Project Grants Research Support Resources Role Sampling Studies Schools Scientist Services South Carolina Speed Strategic Planning Support Groups Surgeon Technology Technology Assessment Testing Therapeutic Time Tissue Sample Tissues Training Translational Research Translations Universities Veterinarians Work animal care animal facility bench to bedside bone clinical practice clinically relevant college design experience experimental study histotechnology human tissue imaging facilities implantation improved in vivo innovation insight invention operation outreach pre-clinical assessment pre-clinical research preclinical study preservation programs research facility sensor skills tool virtual human

项目摘要

SUMMARY The purpose of translational research is to foster and facilitate technology advancements from the basic sciences to the clinical in vivo realm for the advancement of patient care. The Pre-Clinical Assessment Core (PAC) will serve as a platform to facilitate the transfer of in vitro advances into clinical practice by providing the facilities and expertise to actuate potential technologies into pre-clinical modeling. PAC is founded on Clemson University's long history of musculoskeletal innovation research using animal models and the recently built Clemson University Biomedical Engineering Innovation Campus (CUBEInC). PAC will consolidate these existing research resources and expertise for the translation of innovations at Clemson University and Greenville Health System into a comprehensive network of experts and services to be organized into two complementary thrusts: Animal Modeling and Post-Mortem Assessment (AM-PMA) and Human Cadaveric Modeling (HCM). The AM- PMA thrust builds on established, AAALAC-accredited, research facilities on the Clemson University main campus that provide state-of-the-art support for animal procurement, management and experimental studies. These include the Godley-Snell Research Center and the Clemson University Farms. Additionally, it includes the Clemson University histotechnological facilities including state-of-the-art processing equipment for both routine histology and hard tissue/metal processing including immunohistochemistry and imaging. The HCM thrust builds on the established Bioskills Surgical Training and Innovation Center and other resources at CUBEInC. The PAC leadership team will consist of the thrusts co-directors, both renowned clinicians and scientists, as well as a support group of technical experts and scientists. The overall mission of PAC is to provide mentoring and strategic planning to all SC-TRIMH investigators for the use of live animal models and/or human cadaver models in their research programs to enhance their research, innovation and competitiveness in the field of musculoskeletal health. Through PAC, SC-TRIMH investigators will learn how to develop and implement pre-clinical studies pertinent to musculoskeletal applications and assess the outcomes of their studies. Additionally, PAC will provide translational expertise, support and training for SC- TRIMH investigators, as well as other PIs at Clemson University, in South Carolina, and the IDeA network. The specific aims of the Pre-Clinical Assessment Core, a critical resource for musculoskeletal researchers, are to 1) provide expertise and support for pre-clinical modeling with a “turnkey” approach, 2) support junior investigator for the development of new models of pre-clinical assessment and 3) enhance the in vivo and ex vivo pre-clinical research capability to foster an increase in awareness of the facilities, increase users focused on musculoskeletal and support the coalescing of SC-TRIMH center. COBRE funds will support highly trained technical personnel and resource mentors to assure the operation and maintenance of core facilities as well as the training and mentoring of SC-TRIMH researchers for innovation and its translation.

概括转化研究的目的是促进和促进基础科学的技术进步临床前评估核心（PAC）将应用于临床体内领域，以促进患者护理。作为一个平台，通过提供设施促进体外进展转化为临床实践 PAC 的基础是克莱姆森大学的基础知识和专业知识，可将潜在技术应用到临床前建模中。大学利用动物模型进行肌肉骨骼创新研究的悠久历史以及最近建立的克莱姆森大学生物医学工程创新园区 (CUBEInC) 将整合这些现有的项目。克莱姆森大学和格林维尔健康中心用于转化创新的研究资源和专业知识系统成为一个全面的专家和服务网络，分为两个互补的重点：动物建模和尸检评估 (AM-PMA) 和人体尸体建模 (HCM)。 PMA 的推动力建立在克莱姆森大学主校区已建立的、经 AAALAC 认证的研究设施的基础上。为动物采购、管理和实验提供最先进支持的校园这些研究还包括戈德利-斯内尔研究中心和克莱姆森大学农场。它包括克莱姆森大学的组织技术设施，包括最先进的处理用于常规组织学和硬组织/金属加工的设备，包括免疫组织化学和 HCM 的重点建立在已建立的 Bioskills 外科培训和创新中心的基础上。 CUBEInC 的其他资源 PAC 领导团队将由推力联合董事组成，两人都是知名人士。战士和科学家，以及技术专家和科学家的支持小组的总体使命。 PAC 将为所有 SC-TRIMH 研究人员提供活体动物使用方面的指导和战略规划模型和/或人体尸体模型在他们的研究项目中，以加强他们的研究、创新通过 PAC，SC-TRIMH 调查人员将了解肌肉骨骼健康领域的竞争力和竞争力。如何开发和实施与肌肉骨骼应用相关的临床前研究并评估此外，PAC 将为 SC-提供转化专业知识、支持和培训。 TRIMH 调查人员以及南卡罗来纳州克莱姆森大学和 IDeA 网络的其他 PI。临床前评估核心是肌肉骨骼研究人员的重要资源，其具体目标是 1) 通过“统包”方法为临床前建模提供专业知识和支持，2) 支持初级人员研究者开发新的临床前评估模型，并3）增强体内和体外试验 vivo 临床前研究能力，以促进设施意识的提高，提高用户的关注度肌肉骨骼领域并支持 SC-TRIMH 中心的合并，COBRE 资金将支持训练有素的人员。技术人员和资源导师，确保核心设施的运行和维护以及 SC-TRIMH 研究人员创新及其转化的培训和指导。