Role of NOD2 in Inflammatory Arthritis and Innate Immunity

NOD2 在炎症性关节炎和先天免疫中的作用

• 批准号: 7782726
• 负责人: MICHAEL Patrick DAVEY
• 金额: --
• 依托单位: PORTLAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7782726
• 关键词: Acetylmuramyl-Alanyl-Isoglutamine; Acute suppurative arthritis due to bacteria; Address; Agonist; Agreement; Amino Acids; Animal Model; Antibodies; Arterial Fatty Streak; Arthritis; Asthma; Autoantigens; Autoimmunity; B-Lymphocytes; Bacteria; Binding; Biochemical; C-terminal; Caspase; Cell Wall; Cells; Characteristics; Chronic; Colitis; Colorectal Cancer; Complex; Conflict (Psychology); Coronary Arteriosclerosis; Coronary artery; Crohn' s disease; Data; Dermatitis; Development; Disease; Disease Clusterings; Double-Stranded RNA; Eczema; Epitopes; Etiology; Exposure to; Eye; Family; Family member; Flagellin; Funding; Genetic; Gram-Positive Bacteria; Granulomatous; Health; Healthcare; Histopathology; Homeostasis; Host Defense; Human; Hypersensitivity; Immune; Immune response; Immune system; Immunologic Receptors; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Injury; Insurance Claim Review; Interleukin-1; Intra-Articular Injections; Invaded; Investigation; Joints; Knockout Mice; Lesion; Leucine-Rich Repeat; Life; Ligands; Link; Lipopolysaccharides; Lipoproteins; Mitogen-Activated Protein Kinases; Modeling; Molecular; Mononuclear; Mus; Mutation; N-terminal; Natural Immunity; Nature; Nucleic Acids; Nucleotides; Onset of illness; Organ; Outcome; Pathogenesis; Pathology; Pathway interactions; Patients; Pattern; Pattern recognition receptor; Peptidoglycan; Peripheral; Physiological; Play; Poly C; Poly I-C; Principal Investigator; Process; Production; Proteins; Proteoglycan; Proteomics; RNA; Receptor Activation; Receptor Cross-Talk; Recurrence; Regulation; Regulatory Pathway; Reporting; Rheumatoid Arthritis; Role; Sarcoidosis; Septic Shock; Site; Skin; Specificity; Spondylarthropathies; Staphylococcus aureus; Stimulus; Streptococcus Group B; Structure; Syndrome; Synovial Membrane; Systemic Lupus Erythematosus; T cell response; T-Cell Receptor; T-Lymphocyte; TLR2 gene; TLR3 gene; Testing; Time; Tissues; Toll-Like Receptor 2; Toll-like receptors; Transgenic Mice; Transgenic Organisms; Tropism; Uveitis; Variant; Veterans; Viral; Virus; Wild Type Mouse; Work; Yeasts; Zymosan; adaptive immunity; aggrecan; arthropathies; cytokine; dectin 1; early onset; follow-up; human TLR8 protein; in vitro Assay; in vivo Model; innate immune function; meetings; member; microbial; mucosa-associated lymphoid tissue lymphoma; novel; nucleotide receptor; oligoadenylate; pathogen; protein protein interaction; public health relevance; receptor; receptor function; research study; response; transcription factor; viral RNA