Aflatoxin exposure and hepatocellular carcinoma in Mexico

墨西哥的黄曲霉毒素暴露与肝细胞癌

基本信息

批准号：
10238151
负责人：
Martin Lajous
金额：
$ 12.17万
依托单位：
MEXICO NATIONAL INSTITUTE OF PUBLIC HLTH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10238151
关键词：
Address Affect Aflatoxin B1 Aflatoxins Africa South of the Sahara Albumins Alcohols Americas Area Automobile Driving Biological Markers Blood Cancer Burden Cancer Etiology Cancer Research Network Central America Cessation of life Characteristics Clinical Collaborations Communities Country Data Diabetes Mellitus Environment Environmental Health Environmental Pollution Epidemiology Etiology Evaluation Exons Exposure to Face Far East Female Food Fostering Future Gene Mutation Geography Guatemala HBV and Aflatoxin Health Surveys Hepatitis B Prevalence Hepatitis B Virus Hepatitis C virus High Prevalence Hispanics Hospitals Immigrant Incidence Induced Mutation Infection Institution International Liver Low Prevalence Maize Measures Metabolic syndrome Mexican Americans Mexico Missense Mutation Mutation Needs Assessment Nutrition Surveys Obesity Pattern Population Primary carcinoma of the liver cells Public Health Records Research Research Activity Research Infrastructure Research Personnel Resources Risk Risk Factors Rural Rural Population Sampling Scientist Seroprevalences Serum Surveys TP53 gene Tumor Tissue Variant Woman Work adduct anticancer research base biobank burden of illness cancer epidemiology cancer prevention dietary environment related cancer insight male men mortality prospective public health relevance rural area

项目摘要

PROJECT SUMMARY Aflatoxin B1 (AFB1) is a fungal contaminant in food that may be exerting a significant impact on the increasing hepatocellular cancer (HCC) burden in Mexico. HCC epidemiology in Mexico is unusual given the low prevalence of hepatitis virus B and C infection, similar HCC mortality among men and women, and a rural-urban gradient. In Mexico, maize, a staple food, appears to be commonly contaminated by aflatoxins. Thus, AFB1 contamination alone or in combination with non-viral risk factors may be driving HCC incidence rates. We aim to provide initial data on the relevance of AFB1 for HCC in Mexico, while strengthening research capacity for future needs. We specifically will (1) measure circulating AFB1 from 955 women and men from four high HCC burden areas; and (2) create a research network to retrospectively identify aflatoxin-induced mutations in liver samples and determine the feasibility of prospectively obtaining clinical information and biospecimens from incident HCC cases. We will gain insight into HCC risk factors in a population with a unique epidemiological pattern, demonstrate our capacity to access an existing biorepository that will become an important resource for future environmental and cancer research, and create a strong research environment that will foster future collaborative efforts with local, regional, and international scientists.

项目概要黄曲霉毒素 B1 (AFB1) 是食品中的一种真菌污染物，可能对健康产生重大影响。墨西哥肝细胞癌（HCC）负担增加。墨西哥的 HCC 流行病学不同寻常鉴于乙型和丙型肝炎病毒感染率较低，男性和女性的肝癌死亡率相似女性和城乡梯度。在墨西哥，玉米作为主食似乎很常见被黄曲霉毒素污染。因此，AFB1 污染单独或与非病毒风险相结合因素可能会推动 HCC 发病率。我们的目标是提供有关 AFB1 相关性的初始数据墨西哥的 HCC，同时加强研究能力以满足未来需求。我们特别将 (1) 测量来自四个 HCC 高负担地区的 955 名女性和男性的循环 AFB1；和（2）创建一个研究网络来回顾性识别肝脏样本中黄曲霉毒素诱导的突变确定从事件中前瞻性获取临床信息和生物样本的可行性肝癌病例。我们将深入了解具有独特流行病学特征的人群中的 HCC 危险因素模式，展示我们访问现有生物样本库的能力，该生物样本库将成为一个重要的为未来环境和癌症研究提供资源，并创造强大的研究环境这将促进未来与当地、区域和国际科学家的合作。