Prenatal Pollution, Stress and Maternal-child Health: Role of Immunomodulation

产前污染、压力与母婴健康：免疫调节的作用

基本信息

批准号：
8898803
负责人：
Perry Elizabeth Sheffield
金额：
$ 16.43万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8898803
关键词：
Address Adult Air Air Pollutants Air Pollution Allergens Area Award Biological Biological Markers Birth Birth Weight Boston Carbon Black Cardiovascular system Cessation of life Characteristics Child Child Development Child health care Climate Community Health Community Healthcare Complex Data Development Plans Dose Elements Environmental Epidemiology Environmental Exposure Environmental Health Environmental Medicine Environmental Risk Factor Epidemiology Exposure to Familiarity Gender Gestational Age Goals Health Hybrids Immune Immunology Impairment Infant Inflammatory Intervention Knowledge Life Link Literature Low Birth Weight Infant Low income Maternal Exposure Maternal and Child Health Mental Depression Mental Health Mentorship Methods Mission Modeling Mothers Nature Neurocognitive New York Occupational Medicine Organism Outcome Output Particulate Particulate Matter Pathway interactions Pediatrics Perinatal Play Pollution Population Population Heterogeneity Positioning Attribute Postpartum Depression Postpartum Period Pregnancy Pregnant Women Preventive Medicine Psychiatry Psychosocial Stress Public Health Recruitment Activity Research Research Personnel Research Training Risk Factors Role Sampling Sex Characteristics Site Statistical Methods Stress Subgroup Techniques Time Toxic effect Training Work ambient air pollution biological adaptation to stress burden of illness career career development caregiving climate change climate data cohort depressive symptoms design disability experience health disparity immunoregulation inflammatory marker intergenerational land use male medical schools multidisciplinary novel pediatrician premature prenatal prenatal exposure prenatal stress professor programs psychologic public health relevance respiratory respiratory health sex skills social model thermal stress toxicant

项目摘要

DESCRIPTION (provided by applicant) The goal of this Career Development Plan is to launch an independent research career in children's environmental health, specializing in climate change research, with a focus on the health vulnerabilities of children. Climate change will impact health by changing the landscape with respect to allergens, pollution, extreme storms, and thermal stress. The health care community can best reduce the burden of climate change on health through targeted interventions for specific vulnerabilities. Research on these vulnerabilities requires advanced epidemiologic skills. This Career Development Plan will build on the candidate's formal training in pediatrics to obtain the background in environmental epidemiology needed to develop hypotheses and design environmental health studies that are well-grounded in biological mechanisms of toxicity. This plan incorporates didactic training in environmental epidemiology and complex statistical techniques. The research component builds on a dual-site prenatal cohort recruited in Boston and New York: the Programming of Intergenerational Stress Mechanisms (PRISM) study. The research will examine the role of prenatal air pollution, psychosocial stress, and immune mechanisms in maternal-child health. The candidate is an Assistant Professor in the Departments of Preventive Medicine and Pediatrics at the Icahn School of Medicine at Mount Sinai, a nationally and internationally recognized center of excellence in preventive medicine, occupational and environmental medicine, community health, and environmental pediatrics. An interdisciplinary mentorship team has been selected to provide guidance and expertise in environmental epidemiology, psychosocial stress, immunology, and psychiatry. The proposed training and research program will position the candidate to work effectively with a number of active, multidisciplinary groups at the completion of the award period. The project is guided by the following career objectives: 1) to gain knowledge on diverse methods of spatial modeling for social and physical environmental exposure assessment; 2) to gain experience working with observed and modeled climate data, in particular, downscaled climate model outputs; 3) to develop expertise in advanced statistical methods relevant to climate and health work specifically focusing on air pollution, stress, and inflammatory biomarkers; 4) to acquire familiarity with additional climate-sensitive outcomes such as birth and mental health outcomes and mechanistic intermediaries. This career development plan will facilitate the candidate becoming a leading expert and independent investigator in children's environmental health and advance the NIH's mission to seek fundamental knowledge about the nature of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.

描述（由申请人提供）这项职业发展计划的目的是在儿童环境健康方面启动独立的研究职业，专门研究气候变化研究，重点是儿童的健康脆弱性。气候变化将通过改变过敏原，污染，极端风暴和热应力来影响健康。卫生保健社区可以通过针对特定漏洞的有针对性的干预措施来最好地减轻健康气候变化的负担。对这些漏洞的研究需要高级流行病学技能。这项职业发展计划将基于候选人在儿科的正式培训，以获取开发假设和设计环境健康研究所需的环境流行病学背景，这些研究在毒性的生物学机制中取决于良好的基础。该计划结合了环境流行病学和复杂统计技术的教学培训。该研究组件建立在波士顿和纽约招募的双站点产前队列的基础上：代际压力机制的编程（PRISM）研究。该研究将研究产前空气污染，社会心理压力和免疫机制在产妇健康中的作用。该候选人是西奈山伊坎医学院的预防医学和儿科系的助理教授，这是一家国家和国际公认的预防医学，职业和环境医学，社区健康和环境儿科的卓越中心。已选择了一个跨学科指导团队来提供环境流行病学，社会心理压力，免疫学和精神病学方面的指导和专业知识。拟议的培训和研究计划将使候选人在奖励期结束时与许多活跃的多学科小组有效合作。该项目以以下职业目标为指导：1）获得有关社会和身体环境暴露评估的空间建模方法的知识； 2）获得与观察和建模的气候数据一起工作的经验，尤其是缩小的气候模型输出； 3）在与气候和健康工作有关的高级统计方法方面发展专业知识，专门针对空气污染，压力和炎症生物标志物； 4）熟悉其他对气候敏感的结果，例如出生，心理健康成果和机械中介机构。这项职业发展计划将促进候选人成为儿童环境健康方面的领先专家和独立研究者，并促进NIH寻求有关生活系统本质的基本知识以及该知识的应用以增强健康，延长寿命，减少疾病和残疾。