Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit

丙酮酸脱氢酶激酶作为肝脂肪变性、肥胖症的治疗靶点

• 批准号: 7782816
• 负责人: ROBERT A HARRIS
• 金额: --
• 依托单位: RLR VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2012-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7782816
• 关键词: Abbreviations; Accounting; Acetoacetates; Acetyl-CoA Carboxylase; Acyl Coenzyme A; Adipose tissue; Affect; Alanine; American; Animal Feed; Automobile Driving; Back; Benign; Blood; Blood Glucose; Branched-Chain Amino Acids; C-reactive protein; Caprylates; Carbon; Carnitine O-Palmitoyltransferase; Characteristics; Cholesterol; Cirrhosis; Coenzyme A; Coenzymes; Commit; Development; Diabetes Mellitus; Dichloroacetate; Diet; Dioxins; Documentation; Down-Regulation; Dual-Energy X-Ray Absorptiometry; Engineering; Enzyme Activation; Enzymes; Esters; Fasting; Fatty Acids; Fatty Liver; Fatty acid glycerol esters; Glucocorticoids; Gluconeogenesis; Glucose; Glutamates; Glycerol; Goals; Healthcare; Hepatocyte; Herbicides; Hormonal; Hormones; Hospitals; Hyperglycemia; Inflammation; Insulin; Insulin Resistance; Interleukin-6; Intervention; Isoenzymes; Ketone Bodies; Knock-out; Knockout Mice; Laboratories; Lead; Learning; Link; Liver; Liver Cirrhosis; Liver Failure; Liver diseases; Malonyl Coenzyme A; Metabolic; Mitochondria; Molecular; Multienzyme Complexes; Mus; Muscle; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Obesity; Oxidative Stress; PDH kinase; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phosphoenolpyruvate Carboxylase; Phosphorylation; Population; Portal Hypertension; Preparation; Prevention; Protein Biosynthesis; Pyruvate; Pyruvate Dehydrogenase Complex; Regulation; Relative (related person); Research; Risk; Risk Factors; Role; Shipping; Ships; Skeletal Muscle; Starvation; Testing; Therapeutic; Tissues; Triglycerides; United States Department of Veterans Affairs; Veterans; Vietnam; Wild Type Mouse; Work; alpha-glycerophosphoric acid; base; beta-Hydroxybutyrate; blood glucose regulation; carbon compound; diabetic patient; fasting blood glucose level; fatty acid oxidation; feeding; glucose metabolism; glucose production; glucose tolerance; improved; inflammatory marker; inhibitor/antagonist; insulin sensitivity; ketogenesis; killings; kinase inhibitor; knockout animal; lipid metabolism; meetings; neuronal cell body; non-alcoholic fatty liver; nonalcoholic steatohepatitis; novel; oxidation; preference; prevent; public health relevance; response; saturated fat; small molecule; therapeutic target; transamination