Sodium Channels in Spinal Cord Injury, Nerve Injury and Neuropathic Pain

脊髓损伤、神经损伤和神经性疼痛中的钠通道

• 批准号: 7920023
• 负责人: Stephen Waxman
• 金额: --
• 依托单位: VA CONNECTICUT HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7920023
• 关键词: ANXA2 gene; ASIC channel; Address; Adverse effects; Affect; Amputation; Animal Model; Attenuated; Autoimmune Diseases; Axon; Axotomy; Behavior; Binding; Biological Assay; Cardiac; Cell membrane; Cell surface; Complex; Coupled; Data; Dependence; Diffuse; Disease; Dominant-Negative Mutation; Exhibits; Exposure to; Genetic Polymorphism; Health; Human; Immune Cell Activation; Inflammation Mediators; Inflammatory; Injury; Knock-in Mouse; Knockout Mice; Knowledge; Length; Lesion; Limb structure; MAP Kinase Gene; MAPK11 gene; MAPK14 gene; MAPK3 gene; Measures; Mechanoreceptors; Mediating; Medical; Messenger RNA; Methods; Mitogen-Activated Protein Kinases; Modeling; Molecular; Multiple Sclerosis; Mus; Nerve; Neuroma; Neuronal Injury; Neurons; Nociception; Nociceptors; P2X-receptor; Pain; Pain Threshold; Patients; Peripheral; Phosphorylation; Phosphorylation Site; Population; Principal Investigator; Production; Property; Protein Isoforms; Proteins; Regulation; Reporter; Research; Reverse Transcriptase Polymerase Chain Reaction; Role; Running; Serine; Site; Sodium Channel; Spinal; Spinal Ganglia; Spinal cord injury; Surface; System; TNF gene; TRP channel; TRPV1 gene; Testing; Therapeutic; Therapeutic Intervention; Time; Tissues; Transfection; Traumatic Nerve Injury; Up-Regulation; Veterans; blind; channel blockers; chronic pain; clinically significant; contactin; cytokine; density; effective therapy; falls; in vivo; inflammatory neuropathic pain; inflammatory pain; mitogen-activated protein kinase p38; neoplastic; nerve injury; painful neuropathy; patch clamp; programs; public health relevance; research study; restriction enzyme; therapeutic target; voltage