Nascent SOD1 in Amyotrophic Lateral Sclerosis

肌萎缩侧索硬化症中的新生 SOD1

• 批准号: 7907877
• 负责人: Peter JOHN HART
• 金额: --
• 依托单位: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7907877
• 关键词: 3-Dimensional; Address; Adopted; Affect; Affinity; Age; Aging-Related Process; Amino Acid Substitution; Amino Acids; Amyotrophic Lateral Sclerosis; Antioxidants; Behavior; Binding; Binding Sites; Biochemistry; Cessation of life; Child; Complex; Consultations; Copper; Cultured Cells; DNA Sequence Rearrangement; Data; Defect; Degenerative Disorder; Dimensions; Disease; Dissociation; Disulfides; Enzymes; Event; Exercise; Failure; Familial Amyotrophic Lateral Sclerosis; Family; Future; Gel Chromatography; Generations; Genes; Health Sciences; Hospitals; Human; Inherited; Ions; Iraq; Laboratories; Lead; Lesion; Letters; Light; Link; Measurement; Mediating; Metalloproteins; Metals; Methods; Military Personnel; Modeling; Molecular; Molecular Chaperones; Molecular Conformation; Motion; Motor Neuron Disease; Motor Neurons; Mus; Mutation; Neurodegenerative Disorders; Neurons; Paralysed; Parents; Pathway interactions; Patients; Population; Post-Translational Protein Processing; Process; Proline; Proteins; Relative (related person); Reporting; Resolution; SOD1 gene; Sampling; Site; Solutions; Spinal Cord; Structure; Study Section; Temperature; Testing; Texas; Therapeutic; Therapeutic Agents; Time; Toxic effect; Transgenic Mice; Translating; United States; Universities; Variant; Veterans; War; Work; X ray diffraction analysis; X-Ray Crystallography; X-Ray Diffraction; analytical ultracentrifugation; base; cofactor; conformer; copper zinc superoxide dismutase; design; disease-causing mutation; disulfide bond; gain of function; gel electrophoresis; human tissue; in vivo; interest; melting; molecular mass; mouse model; mutant; oxidation; polypeptide; protein aggregation; protein misfolding; public health relevance; relating to nervous system; research study; sedimentation equilibrium; sedimentation velocity; tool