Mu-Opioid Effects on the Central Mechanisms that Control Breathing

Mu-阿片类药物对控制呼吸的中枢机制的影响

• 批准号: 8195947
• 负责人: Edward J Zuperku
• 金额: --
• 依托单位: CLEMENT J. ZABLOCKI VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195947
• 关键词: AMPA Receptors; Absence of pain sensation; Acute; Acute Pain; Address; Adrenergic Agents; Adrenergic Receptor; Adverse effects; Affect; Agonist; Amines; Analgesics; Apnea; Area; Axon; Bathing; Bilateral; Biogenic Amine Receptors; Brain; Brain Neoplasms; Brain Stem; Breathing; Canis familiaris; Cardiovascular system; Cell Nucleus; Cells; Cervical spinal cord structure; Chronic; Clinical; Complex; Computers; Consensus; Degenerative Disorder; Depressed mood; Disease; Dopamine; Dopamine Agonists; Dorsal; Effectiveness; Electrodes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Environmental air flow; Exhibits; Felis catus; Fentanyl; Financial compensation; Frequencies; Generations; Glutamates; Glycine Receptors; Head; Hypertension; In Vitro; Infusion procedures; Injury; Intravenous infusion procedures; Knowledge; Laboratories; Life; Lung; Malignant Neoplasms; Measures; Mediating; Mental Depression; Metabolic syndrome; Methods; Microinjections; Modeling; Monitor; Morphine; N-Methyl-D-Aspartate Receptors; Naloxone; Narcotic Antagonists; Neuromodulator; Neurons; Neuropharmacology; Neurotransmitters; Norepinephrine; Nucleus solitarius; Obstructive Sleep Apnea; Opiates; Opioid; Opioid Analgesics; Opioid Receptor; Pain; Pain management; Pathologic; Pattern; Perioperative; Pharmaceutical Preparations; Pharmacology; Phase; Plasma; Pontine structure; Population; Postoperative Pain; Property; Pulmonary Stretch Receptors; Pump; Rattus; Receptor Inhibition; Respiration; Respiratory physiology; Role; Series; Serotonin; Serotonin Agonists; Simulate; Site; Structure of phrenic nerve; Surface; Synapses; System; Techniques; Therapeutic; Tidal Volume; Time; Trauma; Ventilatory Depression; Veterans; Work; adrenergic; airway obstruction; analog; base; chronic pain; clinical application; clinically relevant; density; design; dosage; immunoreactivity; in vivo; insight; lateral column; mu opioid receptors; network models; neurophysiology; neurotransmission; noradrenergic; patient population; postsynaptic; presynaptic; prevent; receptor; remifentanil; research study; respiratory; response; serotonin receptor; therapeutic target