Low Cost Device for Detection of Retinal Disease

用于检测视网膜疾病的低成本设备

基本信息

  • 批准号:
    8125827
  • 负责人:
  • 金额:
    $ 50.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-07-01 至 2013-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The overall goal of the proposed SBIR program is to develop the powerful Laser Scanning Digital Camera Stimulator (LSDC-S), for fundus imaging and accurate retinal localization during visual function assessment. Low vision, due to retinal disease and other visual pathway damage, is on the increase worldwide. Retinal disease often goes undetected until vision is lost, and rehabilitation with vision aids is more difficult and less successful with increasing vision loss. Localizing the retinal damage, when present, and determining the functional vision of patients, may help optimize the selection of vision aids. Although the stability of gaze affects case management, instrumentation to determine this accurately and in comparison to retinal damage is not widely used. Fixation stability and defects in central vision will be mapped, e.g. in age-related macular degeneration and macular edema. Peripheral vision will be mapped in diseases such as glaucoma. Aeon's goal is to help provide cost effective eye care by putting instrumentation into the hands of clinicians and researchers that provides detection of pathology that will improve success with aids. The LSDC uses dim, safe near infrared light, an ideal background for viewing and retinal tracking. Aeon will build on the Phase I LSDC imager that uses a novel, hybrid confocal system with a scanning slit for illumination and a two dimensional solid state array for detection. In Phase II, Aeon will 1) Build the Laser Scanning Digital Camera Stimulator (LSDC-S) so that visual stimuli are presented simultaneously with retinal imaging, and with real-time recording of patient response, 2) Optimize the LSDC-S design for wide and magnified field of view for imaging and display matched to the task, 3) Provide new methods to assess fixation and target detection in low vision patients, 4) Perform a design review for commercialization. Underlying the high contrast images is a novel, patented core technology and robust architecture. Applications include early detection of choroidal neovascularization, detection of cystoid macular edema, investigating macular sparing, mapping the Preferred Retinal Locus, mapping the peripheral field of view accurately for medical/legal decisions, improved rehabilitation with prisms and magnifiers, and providing sharable digital retinal images. In this Phase II proposal, Aeon will provide significant, novel functionality in two models of their LSDC-S, which perform vision assessment during accurate retinal localization. The LSDC-S will help low vision practitioners determine where a patient is looking and whether gaze is steady, along with mapping out vision defects and assessing visual acuity in age-related macular degeneration, glaucoma, macular edema, and other eye and systemic conditions. The research LSDC-S is aimed at clinician scientists/vision researchers, with both models featuring retinal imaging is comfortable for patients and provides high contrast retinal images for their care providers. PUBLIC HEALTH RELEVANCE: Aeon Imaging, LLC, will help provide cost effective eye care by developing a new product, the Laser Scanning Digital Camera Stimulator (LSDC-S), to perform vision assessment with a simultaneous and high contrast retinal image. The LSDC-S will provide the low vision specialist or researcher a uniquely wide selection of fields of view, allowing for the macula or the visual periphery to be assessed with high precision. The retinal localization of visual targets is provided by comfortable and non-mydriatic imaging using near infrared light and helps the clinician or researcher detect retinal pathology to provide more optimal patient management.
描述(由申请人提供):拟议的SBIR计划的总体目标是开发功能强大的激光扫描数码相机刺激器(LSDC-S),用于在视觉功能评估过程中对于眼底成像和准确的视网膜定位。由于视网膜疾病和其他视觉途径损害,低视力正在全球增加。视网膜疾病通常无法被发现直到视力丧失为止,并且随着视力丧失的增加,视力艾滋病的康复更加困难,更成功。在场时将视网膜损伤定位,并确定患者的功能视觉,可能有助于优化视力辅助物的选择。尽管目光的稳定性影响了病例管理,但与视网膜损伤相比,仪器的确定仪器并未得到广泛使用。将映射固定稳定性和中央视力中的缺陷,例如与年龄相关的黄斑变性和黄斑水肿。外围视力将在青光眼等疾病中映射。 AEON的目标是通过将仪器置于临床医生和研究人员的手中来帮助提供具有成本效益的眼部护理,这些仪器提供了发现可以改善艾滋病成功的病理学。 LSDC使用昏暗,安全的近红外光,这是观看和视网膜跟踪的理想背景。 AEON将建立在I阶段LSDC成像仪上,该Imdc Imager使用具有扫描缝隙的新型混合聚焦系统,用于照明和二维固态阵列进行检测。在第二阶段,永旺将1)构建激光扫描数码摄像机刺激器(LSDC-S),以便与视网膜成像同时介绍视觉刺激,并实时记录患者反应,2)优化LSDC-S设计,以评估与任务相匹配的广泛和放大的视野,以评估固定方法的范围,以评估固定方法,以固定为4),以固定为4),并在固定方面进行固定,以固定为4)。高对比度图像的基础是一种新颖,专利的核心技术和强大的建筑。应用包括早期检测脉络膜新生血管形成,检测囊状黄斑水肿,研究黄斑的避免,绘制首选的视网膜基因座,绘制准确的医疗/法律决策的外围视野,用棱镜和大放大镜进行改进的康复,并提供可靠的数字视网膜图像。在此II阶段提案中,AEON将在其LSDC-S的两个模型中提供重要的新功能,这些功能在准确的视网膜定位期间进行视觉评估。 LSDC-S将帮助低视力从业人员确定患者在哪里寻找的位置以及凝视是否稳定,并绘制视力缺陷以及评估年龄相关的黄斑变性,青光眼,黄斑水肿以及其他眼睛和全身状况的视力。 LSDC-S的研究针对临床医生/视觉研究人员,这两种模型都具有视网膜成像,适合患者,并为其护理人员提供高造影剂的视网膜图像。 公共卫生相关性:Aeon Imaging,LLC将通过开发新产品,激光扫描数码相机刺激器(LSDC-S)来帮助提供具有成本效益的眼部护理,以同时且高对比度的视网膜图像进行视觉评估。 LSDC-S将为低视力专家或研究人员提供独特的视野选择,从而可以高精度地评估黄斑或视觉外围。视觉目标的视网膜定位是通过使用近红外光进行舒适和非毛线成像提供的,并帮助临床医生或研究人员检测视网膜病理学以提供更佳的患者管理。

项目成果

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Benno L Petrig其他文献

Benno L Petrig的其他文献

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{{ truncateString('Benno L Petrig', 18)}}的其他基金

Low Cost Device for Detection of Retinal Disease
用于检测视网膜疾病的低成本设备
  • 批准号:
    8309984
  • 财政年份:
    2008
  • 资助金额:
    $ 50.02万
  • 项目类别:
Low Cost Device for Detection of Retinal Disease
用于检测视网膜疾病的低成本设备
  • 批准号:
    7395136
  • 财政年份:
    2008
  • 资助金额:
    $ 50.02万
  • 项目类别:

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